Search results for "Anatabine"
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Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease.
2017
Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway. They inhibit the phosphorylation or the ubiquitination of signaling molecules, and thus, inhibit the degradation of IκB. The translocation of NF-κB to the nucleus and subsequent tr…
Rapid method for analysis of nicotine and nicotine-related substances in chewing gum formulations
1998
Abstract Based on environmental requirements and demands for a high throughput a rapid method for the analysis of nicotine and nicotine-related substances in chewing gum formulations was developed. The method is based on sample preparation through liquid–liquid extraction followed by reversed-phase HPLC using gradient elution. It allowed up to nine analytes to be determined within 15 min, including the sample preparation, and was considered as accurate and robust.