6533b871fe1ef96bd12d0d88

RESEARCH PRODUCT

Rapid method for analysis of nicotine and nicotine-related substances in chewing gum formulations

Börje SellergrenThomas RennerÅSa ZanderAleksander Swietlow

subject

ChromatographyElutionOrganic ChemistryAnabasineGeneral MedicineBiochemistryHigh-performance liquid chromatographyDosage formAnalytical ChemistryNicotinechemistry.chemical_compoundchemistrymedicineSample preparationMyosmineAnatabinemedicine.drug

description

Abstract Based on environmental requirements and demands for a high throughput a rapid method for the analysis of nicotine and nicotine-related substances in chewing gum formulations was developed. The method is based on sample preparation through liquid–liquid extraction followed by reversed-phase HPLC using gradient elution. It allowed up to nine analytes to be determined within 15 min, including the sample preparation, and was considered as accurate and robust.

yearjournalcountryeditionlanguage
1998-12-01Journal of Chromatography A
https://doi.org/10.1016/s0021-9673(98)00798-5