0000000000311398
AUTHOR
Thomas Renner
showing 2 related works from this author
Analysis of Nicotine and Its Oxidation Products in Nicotine Chewing Gum by a Molecularly Imprinted Solid-Phase Extraction
2000
Chromatographic stationary phases showing exceptional selectivity for nicotine can be prepared by the technique of molecular imprinting. Such phases were used in the search for a rapid cleanup step for nicotine and some of its oxidation products in chewing gum formulations. Thus, using an organic mobile phase, the nicotine analytes from chewing gums dissolved in nonpolar solvent were retained, whereas the nonpolar matrix eluted close to the void peak. A subsequent switch to an acidic mobile phase resulted in elution of the analytes as one sharp peak. Due to weak binding of the less basic oxidation products, other imprinted polymers were tested, and the solid-phase extraction procedure was o…
Rapid method for analysis of nicotine and nicotine-related substances in chewing gum formulations
1998
Abstract Based on environmental requirements and demands for a high throughput a rapid method for the analysis of nicotine and nicotine-related substances in chewing gum formulations was developed. The method is based on sample preparation through liquid–liquid extraction followed by reversed-phase HPLC using gradient elution. It allowed up to nine analytes to be determined within 15 min, including the sample preparation, and was considered as accurate and robust.