Search results for "Anatomia"

CIRCULATING AND TISSUE FORMS OF MMP2 AND MMP9 IN BREAST CANCER PROGRESSION

2010

Tumor progression and metastasis represent the leading causes of cancer related death. One of the major features that may contribute to neoplastic cell dissemination is the progressive and local degradation of the extracellular matrix (ECM) surrounding the primary tumour. Degradation of the ECM requires the coordinated action of a number of enzymes produced locally by neoplastic cells and/or stromal cells. Five categories of proteinases have been implicated in the invasive process: serine, cysteine, aspartic, threonine proteinases and matrix metalloproteinases (MMPs), also known as matrixins, which play a key role as terminal effectors of the proteolytic cascade. At present 23 members of th…

Meccanismo di rilascio di Hsp70 tramite vescicole di membrana e suo ruolo nella migrazione di cellule staminali di topo

2014

Mouse mesoangioblast are vessel-derived stem cells which are able to differentiate in most mesodermal tissues, and have also the ability to migrate and cross the endothelial barrier. In our previous work we have demonstrated that these cells release in the extracellular medium membrane vesicles containing matrix metalloproteinases MMP-2 and MMP-9. We have also demonstrated that they express Hsp70 under basal growth condition. According to literature data, the aim of this study was to investigate the possible role of Hsp70 on MMPs regulation. To do this we compared mesoangioblasts A6 cell clone with two other cell clones: NM3, partially knockdown for Hsp70 expression and a cell clone overexp…

MMP-2, MMP-9 and MMP-14 in breast cancer: clinicopathological correlations.

2009

MMP2 synthesis in mouse mesoangioblast stem cells is highly regulated

2012

LARGE-SCALE SCREENING OF MATRIX METALLOPROTEINASES IN BREAST CANCER PATIENTS AND CLINICAL-MOLECULAR CORRELATIONS

2009

Correlation between MMPS and proteomic profiles of breast cancer tissues

2009

Aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cells

2012

Plant aminopropyltransferases consist of a group of enzymes that transfer aminopropyl groups derived from decarboxylated S-adenosyl-methionine (dcAdoMet or dcSAM) to propylamine acceptors to produce polyamines, ubiquitous metabolites with positive charge at physiological pH. Spermidine synthase (SPDS) uses putrescine as amino acceptor to form spermidine, whereas spermine synthase (SPMS) and thermospermine synthase (TSPMS) use spermidine as acceptor to synthesize the isomers spermine and thermospermine respectively. In previous work it was shown that both SPDS1 and SPDS2 can physically interact with SPMS although no data concerning the subcellular localization was reported. Here we study the…

Magnesium deprivation affects development and biomineralization in the sea urchin arba-cia lixula

2018

Skeletogenesis is a key morphogenetic event in the life of marine invertebrates. Marine calcifiers secrete their calcareous skeletons taking up ions from seawater. Marine biominerals include aragonite and calcite, the latter of which in some taxa (e.g. echinoderms, coralline algae) can have a substantial magnesium (Mg) component. Echinoderms have an extensive endoskeleton composed of high magnesian calcite and occluded matrix proteins1. As biomineralization in sea urchin larvae is sensitive to the Magnesium:Calcium ratio of sea water, we investigated the effects of magnesium deprivation on development and skeletogenesis in the Mediterranean sea urchin Arbacia lixula. Microscopic inspection …

Historia de las flegmasias ó inflamaciones crónicas : fundada en nuevas observaciones de clínica y de anatomía patológica

A port.: obra que presenta un cuadro razonado de las diversas variedades y combinaciones de estas enfermedades con sus diferentes métodos curativos Retrat de l’autor al vol. 1, signat: “ P. S. ; F. Suria" Sign.: [ ]4, a-c4, (1-39)4 ; (1-39)4 ; (1-40)4, (41)6 ; (1-34)4, (35)6 Pag.: vol. 1: XXVIII, 311 p., [1] f. de làm.; vol. 2: 312 p.; vol. 3: 332 p.; vol. 4: 276 p Antep. - Notes a peu de pàg. separades del text per filets

The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features

2019

Besides its substantial role in eye lens, αB-crystallin (HSPB5) retains fundamental function in striated muscle during physiological or pathological modifications. In this study, we aimed to analyse the cellular and molecular factors driving the functional response of HSPB5 protein in different muscles from mice subjected to an acute bout of non-damaging endurance exercise or in C2C12 myocytes upon exposure to pro-oxidant environment, chosen as “in vivo” and “in vitro” models of a physiological stressing conditions, respectively.To this end, red (GR) and white gastrocnemius (GW), as sources of slow-oxidative and fast-glycolytic/oxidative fibers, as well as the soleus (SOL), mainly composed …