Search results for "Androgen"
showing 6 items of 326 documents
Diet to Reduce the Metabolic Syndrome Associated with Menopause. The Logic for Olive Oil
2020
The rates of metabolic syndrome are increasing in parallel with the increasing prevalence of obesity, primarily due to its concomitant insulin resistance. This is particularly concerning for women, as the years around menopause are accompanied by an increase in visceral obesity, a strong determinant of insulin resistance. A fall in estrogens and increase in the androgen/estrogen ratio is attributed a determining role in this process, which has been confirmed in other physiological models, such as polycystic ovary syndrome. A healthy lifestyle, with special emphasis on nutrition, has been recommended as a first-line strategy in consensuses and guidelines. A consistent body of evidence has ac…
Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways
2015
The ability of a cell to respond to a particular hormone depends on the presence of specific receptors for those hormones. Once the hormone has bound to its receptor, and following structural and biochemical modifications to the receptor, it separates from cytoplasmic chaperone proteins, thereby exposing the nuclear localization sequences that result in the activation of the receptor and initiation of the biological actions of the hormone on the target cell. In addition, recent work has demonstrated new pathways of steroid signaling through orphan and cell surface receptors that contribute to more rapid, “non-nuclear” or non-transcriptional effects of steroid hormones, often involving G-pro…
Endocrine disrupters: the new players able to affect the epigenome
2015
Epigenetics represents the way by which the environment is able to program the genome; there are three main levels of epigenetic control on genome: DNA methylation, post-translational histone modification and microRNA expression. The term Epigenetics has been widened by NIH to include “both heritable changes in gene activity and expression but also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.” These changes might be produced mostly by the early life environment and might affect health influencing the susceptibility to develop diseases, from cancer to mental disorder, during the entire life span. The most studied environmental i…
Long-term outcome of antiandrogen monotherapy in advanced prostate carcinoma. Twelve-year’s results of a phase II study.
2003
OBJECTIVE: To present the long-term outcome of patients with locally advanced or metastatic prostate carcinoma treated by first-line antiandrogen monotherapy. PATIENTS AND METHODS: From 1983 to 1990, 41 patients with advanced prostate carcinoma were treated with flutamide monotherapy until progression or the appearance of toxicity. Twenty-five patients (61%) had T3-T4N0M0 and 16 (39%) T2-4N0-3M1 prostate carcinoma. Consensus criteria were adopted to evaluate the response. Plasma testosterone and sexual function were recorded for the first 3 years. RESULTS: Flutamide was administered for up to 147 months; seven patients (17%) interrupted the treatment because of toxicity. There was an object…
Hiperandrogenēmijas un insulīna rezistences klīniskās izpausmes pacientēm ar 2. tipa cukura diabētu
2022
CD ir plaši izplatīta saslimšana, kas skar cilvēkus visā pasaulē. Pēdējo 30 gadu laikā, CD pacientu skaits ir divkāršojies, padarot to par vienu no svarīgākajām sabiedrības veselības problēmām visā pasaulē. Ir zināmi vairāki 2.tipa CD attīstības cēloņi, bet vieni no galvenajiem ir aptaukošanās, inulīna rezistence un ģenētiskā predispozīcija. Pacientiem ar 2.tipa CD tiek piedāvāta dažāda veida terapija, kura tiek piemērota katram pacientam individuāli. Lai gan slimība nav pilnībā izārstējama, bet terapija sniedz pacientiem iespēju dzīvot pilnvērtīgāku dzīvi, un samazināt iespējamo ilgtermiņa komplikāciju biežumu un to smaguma pakāpi. Darba mērķi. Noteikt hiperandrogenemijas un insulīna rezis…
The 2D:4D ratio and its relationship with other androgenisation parameters in parents of individuals with autism spectrum disorders.
2013
The 2D:4D ratio is the quotient between the index and ring fin-ger lengths and is a non-direct indicator of androgenisation. If prenatal tes-tosterone levels in the amniotic fluid are high then the probability increases of developing lower ratio values. It has been suggested that people with au-tism spectrum disorders (ASD) and their parents may have highly andro-genised brains, and for this reason the 2D:4D ratio is used as a marker of such idiosyncrasies. This study aims to analyse if parents of people with ASD differ from the general population in several parameters of andro-genisation related to the 2D:4D ratio. The sample was composed of 43 parents of offspring with ASD and 42 controls…