6533b859fe1ef96bd12b6e30
RESEARCH PRODUCT
Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways
John R. BasileValentina ContròPatrizia ProiaPatrizia Proiasubject
orphan receptorreceptorreceptorsandrogenBiologyprogesteronegenomic pathwaySettore BIO/10 - Biochimicaestrogensex steroid hormoneReceptorlcsh:Science (General)Orphan receptorHormone response elementsex steroid hormones; receptors; estrogens; androgens; progesterone; genomic pathway; non-genomic pathway; orphan receptorandrogensSex hormone receptornon-genomic pathwayBiochemistryNuclear receptorSex steroidHormone receptorsex steroid hormonesEstrogen-related receptor gammaestrogenslcsh:Q1-390description
The ability of a cell to respond to a particular hormone depends on the presence of specific receptors for those hormones. Once the hormone has bound to its receptor, and following structural and biochemical modifications to the receptor, it separates from cytoplasmic chaperone proteins, thereby exposing the nuclear localization sequences that result in the activation of the receptor and initiation of the biological actions of the hormone on the target cell. In addition, recent work has demonstrated new pathways of steroid signaling through orphan and cell surface receptors that contribute to more rapid, “non-nuclear” or non-transcriptional effects of steroid hormones, often involving G-protein-mediated pathways. This review will summarize some of these studies for estrogens, androgens and progestins.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | AIMS Molecular Science |