Search results for "Anesthesiology"

showing 10 items of 1218 documents

Methadone response in advanced cancer patients with pain followed at home

1999

Concerns about the safety of therapy with methadone, which may arise because of its pharmacokinetic characteristics and inappropriate dosing, may deter clinicians from using this drug, especially in elderly patients. Experience is accumulating that the drug may be used safely and successfully if low doses are given initially and care is taken in the titration of the dose against the pain. A prospective study was carried out in a consecutive sample of 45 advanced cancer patients followed at home, who had never received other strong opioids for their pain. Patients were treated with an oral liquid preparation of methadone, which was administered 2-3 times daily, according to need. Doses were …

MaleOpioidAdverse effectSex FactorsNeoplasmsHumansMedicineProspective StudiesDosingCancer painAdverse effectProspective cohort studyGeneral NursingNursing (all)2901 Nursing (miscellaneous)Pain Measurementbusiness.industryMiddle AgedHome Care ServicesMiddle agePain IntractableAnalgesics OpioidAnesthesiology and Pain MedicineAnesthesiaNeuropathic painAmbulatoryFemaleNeurology (clinical)businessCancer painMethadoneMethadonemedicine.drug
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Investigation of an opioid response categorization in advanced cancer patients

1999

The aim of this study was to investigate a possible distinction in three categories of opioid response and to identify possible factors associated with a poor response. A prospective survey was carried out in 105 consecutive patients requiring morphine for at least 4 weeks before death. Mean pain intensity, opioid doses and symptom intensity at weekly intervals, pain syndromes, and the presence of psychological distress were assessed. Opioid escalation index (OEI%) was calculated from the parameters recorded. Three categories were considered, including (1) patients with slow increments of opioid dose and a mean analgesic 10-cm visual analogue scale (VAS) less than 4 (responders), (2) patien…

MaleOpioid-responsivenePalliative careNauseaVisual analogue scaleAnalgesicPainNeuropathic painNeoplasmsmedicineHumansProspective StudiesCancer painProspective cohort studyGeneral NursingNursing (all)2901 Nursing (miscellaneous)AgedDose-Response Relationship DrugMorphinebusiness.industryData CollectionPsychological distrePalliative CareMiddle AgedAnalgesics OpioidAnesthesiology and Pain MedicineOpioidAnesthesiaNeuropathic painDisease ProgressionFemaleNeurology (clinical)medicine.symptombusinessCancer painmedicine.drug
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Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

2018

Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those…

MaleOriginalEpidemiology[SDV]Life Sciences [q-bio]HSJ UCIlnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]MULTICENTERclinical outcomemortality rateCritical Care and Intensive Care Medicineintensive care unitlaw.invention0302 clinical medicineSeverity of diseaselawEpidemiologymiddle agedMedicine and Health SciencesFAILURE030212 general & internal medicineHospital Mortalityintensive care units -- analysis -- epidemiology -- mortalityGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)CODEScomparative studyintensive careMedicine(all)multilevel analysiIncidenceadultSciences bio-médicales et agricolesIntensive care unit3. Good healthEuropesepsaIntensive Care UnitsfemaleCohortenote intenzivne terapije -- analiza -- epidemiologija -- umrljivostHumanAdultmedicine.medical_specialtyseverity of diseaseCritical CareSepsiIntensive Care UnitUNITED-STATES610 Medicine & healthINTENSIVE-CAREEuropeanArticleSepsisEpidemiology; Sepsis; Severity of disease03 medical and health sciencesAll institutes and research themes of the Radboud University Medical Centerlength of staymaleEpidemiology; Sepsis; Severity of disease; Adult; Europe; Hospital Mortality; Humans; Length of Stay; Male; Critical Care; Intensive Care Units; SepsisAnesthesiologyIntensive careSepsisSCOREmedicineudc:614.2Humanshumanoutcome assessmentSeptic shockbusiness.industrySEPTIC SHOCK030208 emergency & critical care medicineLength of Staymedicine.diseaseTRENDSmajor clinical studySEVERE SEPSIScomorbidity assessmentEmergency medicineEpidemiology; Sepsis; Severity of disease; Critical Care and Intensive Care MedicineObservational studyCLAIMSbusinessSepsis;Severity of disease;Epidemiologyresnost bolezni
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

2020

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347

MaleOriginalmedicine.medical_treatmentartificialCritical Care and Intensive Care MedicineMedical and Health SciencesPressure ulcerlaw.inventionDecubitus epidemiology; ICU; Morbidity; Mortality; Outcome; Pressure injury; Pressure ulcer; Risk factors; Adult; Aged; Hospital Mortality; Humans; Male; Patient Discharge; Prevalence; Risk Factors; Intensive Care Units; Respiration Artificial0302 clinical medicineDecubitus epidemiologydecubitus epidemiology ; ICU ; pressure injury ; pressure ulcer ; outcome ; risk factors ; morbidity ; mortalitylawMedicine and Health SciencesadultsPrevalenceMedicineHospital MortalitySimplified Acute Physiology Scoredecubitus epidemiology; icu; pressure injury; pressure ulcer; outcome; risk factors; morbidityziekenhuissterfteImmunodeficiencyintensive careOutcomeEuropean Society of Intensive Care Medicine (ESICM) Trials Group CollaboratorsmannenvolwassenenCOSTIntensive care unitSTATEPatient DischargeIntensive Care UnitsULCERSUnderweightmedicine.symptomLife Sciences & BiomedicineDecubitus epidemiology; ICU; Morbidity; Mortality; Outcome; Pressure injury; Pressure ulcer; Risk factorsHumanAdultmedicine.medical_specialtyrisicofactorenDecubitus epidemiology ICU Pressure injury Pressure ulcer Outcome Risk factors Morbidity Mortalitypressure injuriesIntensive Care UnitprevalentieNO1117 Public Health and Health ServicesDecubICUs Study Team03 medical and health sciencesCritical Care MedicineAnesthesiologyGeneral & Internal MedicineHealth SciencesouderenHumansMortalityAgedMechanical ventilationScience & Technologybusiness.industrydecubitusRisk Factor030208 emergency & critical care medicine1103 Clinical SciencesOdds ratiomedicine.diseaseRespiration ArtificialEmergency & Critical Care MedicineConfidence interval030228 respiratory systemRisk factorsEmergency medicineICUkunstmatige ademhalingRISK-FACTORSMorbiditybusinessPressure injuryrespiration
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Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease.

2006

Patients with peripheral arterial disease (PAD) may develop a broad range of peripheral nerve dysfunctions including pain and sensory deficiencies due to chronic ischemia mostly involving the lower limbs. To investigate the degree of sensory abnormalities in such patients quantitative sensory testing (QST) might be a useful tool. Forty-five patients and 20 controls were enrolled in the present study and underwent QST according to the protocol of the German Research Network on Neuropathic Pain. PAD was graded according to the Rutherford classification. PAD patients were divided into two groups: 16 patients with critical limb ischemia (severe PAD) and 29 patients with intermittent claudicatio…

MalePain ThresholdIschemiaSensationSensationmedicineHumansThermosensingAgedPain MeasurementNeurologic ExaminationPeripheral Vascular DiseasesAnalysis of Variancebusiness.industryPeripheral Nervous System DiseasesCritical limb ischemiamedicine.diseaseIntermittent claudicationbody regionsAnesthesiology and Pain MedicinePeripheral neuropathyAllodyniamedicine.anatomical_structureNeurologyAnesthesiaCase-Control StudiesNeuropathic painSensation DisordersFemaleNeurology (clinical)medicine.symptombusinessSensory nervePain
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Explicit episodic memory for sensory-discriminative components of capsaicin-induced pain: Immediate and delayed ratings

2008

Pain memory is thought to affect future pain sensitivity and thus contribute to clinical pain conditions. Systematic investigations of the human capacity to remember sensory features of experimental pain are sparse. In order to address long-term pain memory, nine healthy male volunteers received intrader- mal injections of three doses of capsaicin (0.05, 1 and 20 lg, separated by 15 min breaks), each given three times in a balanced design across three sessions at one week intervals. Pain rating was performed using a computerized visual analogue scale (0-100) digitized at 1/s, either immediately online or one hour or one day after injection. Subjects also recalled their pains one week later.…

MalePain ThresholdRecallVisual analogue scalePainSensory systemAdaptation PhysiologicalPain ratingYoung Adultchemistry.chemical_compoundDiscrimination PsychologicalMemory Short-TermAnesthesiology and Pain MedicineNeurologychemistryCapsaicinDuration (music)AnesthesiaSensory System AgentsHumansNeurology (clinical)CapsaicinPsychologyEpisodic memoryBurning PainPain
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Bone Trauma Causes Massive but Reversible Changes in Spinal Circuitry.

2016

Abstract Bone fracture with subsequent immobilization of the injured limb can cause complex regional pain syndrome (CRPS) in humans. Mechanisms of CRPS are still not completely understood but bone fracture with casting in mice leads to a similar post-traumatic inflammation as seen in humans and might therefore be an analog to human CRPS. In this article we report behavioral and spinal electrophysiological changes in mice that developed swelling of the paw, warming of the skin, and pain in the injured limb after bone fracture. The receptive field sizes of spinal neurons representing areas of the hind paws increased after trauma and recovered over time—as did the behavioral signs of inflammat…

MalePain ThresholdTime FactorsAction PotentialsInflammationStatistics NonparametricWeight-Bearing03 medical and health sciencesFractures BoneMice0302 clinical medicine030202 anesthesiologyPhysical StimulationBiological neural networkMedicineAnimalsEdemaPain MeasurementNeuronsbusiness.industryBone fracturemedicine.diseaseSpinal cordElectric StimulationMice Inbred C57BLElectrophysiologyDisease Models AnimalAnesthesiology and Pain MedicineAllodyniamedicine.anatomical_structureComplex regional pain syndromeNeurologySpinal CordReceptive fieldHyperalgesiaAnesthesiaNeurology (clinical)medicine.symptomNerve NetbusinessSkin Temperature030217 neurology & neurosurgeryComplex Regional Pain SyndromesThe journal of pain
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Response to letter by Werner et al.

2012

MalePain Thresholdbusiness.industrySensationDiagnostic Techniques NeurologicalAnesthesiology and Pain MedicineNeurologyResearch DesignSensation DisordersHumansNeuralgiaMedicineFemaleNeurology (clinical)businessPain
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Dysynchiria is not a common feature of neuropathic pain

2006

Patients with chronic neuropathic pain (non-CRPS) and brush-evoked allodynia watched a reflected image of their corresponding but opposite skin region being brushed in a mirror. Unlike complex regional pain syndrome Type 1, this process did not evoke any sensation at the affected area ('dysynchiria'). We conclude that central nociceptive sensitisation alone is not sufficient to cause dysynchiria in neuropathic pain. The results imply a difference in cortical pain processing between complex regional pain syndrome and other chronic neuropathic pain.

MalePain Thresholdmedicine.medical_specialtyPhysical medicine and rehabilitationThreshold of painmedicineHumansParesthesiaReferred painbusiness.industrydysynchiria; CRPS; neuropathic painNociceptorsMiddle Agedmedicine.diseaseAnesthesiology and Pain MedicineComplex regional pain syndromeAllodyniaNociceptionAnesthesiaChronic DiseaseNeuropathic painOther Psychology and Cognitive SciencesNeuralgiaNociceptorNeuralgiaFemalemedicine.symptombusinessEuropean Journal of Pain
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Ineffectiveness of dextromethorphan in cancer pain

1998

Experimental studies have indicated that N-methyl-D-aspartate (NMDA) receptor antagonists may be effective analgesics in a wide variety of chronic pain states. The mechanism is presumed to be related to decreased firing of dorsal horn neurons after constant repeated C-fiber stimulation. Dextromethorphan (DM), a potent NMDA antagonist with a good safety profile, may be a promising agent for the treatment of persistent pain. An open-label randomized trial was designed to examine the effects of combining DM with NSAIDs, dextropropoxyphene, or morphine in cancer patients with pain. Patients who required a change in the step of the World Health Organization's (WHO) analgesic ladder because of a …

MalePalliative careAnalgesicNeuropathic painDextromethorphanNeoplasmsWHO methodmedicineHumansCancer painGeneral NursingNursing (all)2901 Nursing (miscellaneous)DextropropoxypheneMorphinebusiness.industryPalliative CareChronic painPain scaleMiddle Agedmedicine.diseasePain IntractableAnalgesics OpioidAnesthesiology and Pain MedicineOpioidAnesthesiaNeuropathic painDrug Therapy CombinationFemaleIntractable painNeurology (clinical)businessCancer painExcitatory Amino Acid Antagonistsmedicine.drug
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