Search results for "Anxiolytic"
showing 7 items of 57 documents
Montanoa tomentosa. A review of the new scientific evidence on pharmacological properties
2022
Montanoa tomentosa is a shrub, belonging to the Asteraceae family, originally from Mexico and Central America, and it is known for its medicinal properties. The origins of its use in the field of herbal medicine can be traced back to the Mexican tradition. It was used for sexual dysfunctions. The extract of leaves was used in women to induce menstruation, abortion and labor, and also to reduce postpartum bleeding. The leaves are also used for their diuretic properties and the ground roots are used in the treatment of dysentery. Over time, studies have been conducted to identify the compounds responsible for the therapeutic activity and their mechanism of action. Two studies conducted in rat…
GABAA-receptor Subtypes: Clinical Efficacy and Selectivity of Benzodiazepine Site Ligands
1997
The main inhibitory neurotransmitter receptor of the brain, the gamma-aminobutyric acid type A receptor (GABA[A]), mediates the actions of several classes of clinically important drugs, such as benzodiazepines, barbiturates and general anaesthetics. This review summarizes the current knowledge on how classical benzodiazepines and novel nonbenzodiazepine compounds act on the benzodiazepine site of GABA(A) receptors and on their clinical pharmacology related to anxiolytic, sedative, hypnotic and cognitive effects or side-effects. Partial agonism, receptor subtype selectivity and novel binding sites are discussed as possible strategies to develop new drugs with fewer adverse effects than are s…
Need adapted use of medication in the open dialogue approach for psychosis : a descriptive longitudinal cohort study
2022
Background The open dialogue (OD) approach includes the need-adapted use of psychiatric medication in treating first-episode psychosis (FEP), but there is limited information on how psychiatric medications are actually used in OD-based services. This study aims to analyse long-term medication dispensing patterns among FEP cohort treated according to the OD. Methods The OD cohort consisted of people who received treatment for FEP in the Finnish Western Lapland catchment area at a time of OD implementation (n=61). The comparison group included people whose FEP treatment commenced outside the catchment area during the mid-1990s (n=1378). Data were gathered from national registers from onset to…
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 7-SUBSTITUTED1-ETHYL-3,4,10-TRIMETHYL-1,10-DIHYDRO-11H-PYRAZOLO(3,4-c)(1,6)BENZODIAZOCIN-11-ONE: A NEW RI…
2004
Derivatives of the title ring system of type 10 were obtained in good yield by fusion of the intermediates 12. Attempt to cyclize the acetylamino derivative 9 under Bischler-Napieralski conditions failed because of the insufficient electronic density in the position 4 of the pyrazole ring created by the adjacent carbonyl moiety. The derivatives of the new ring system, assayed as anxiolytic agents, showed no significant activity.
Clinical pharmacology of citrus aurantium and citrus sinensis for the treatment of anxiety
2018
Objective. The aim of this review is to analyze preclinical and clinical studies investigating the anxiety effects ofCitrus aurantiumorCitrus sinensisessential oils (EOs).Design. The bibliographic research was made on the major scientific databases. Analysis included only articles written in English and published on peer-reviewed scientific journals describing preclinical experiments and clinical trials carried out to investigate the antianxiety effects ofCitrus aurantium or Citrus sinensisEOs on anxiety disorders. Clinical studies reporting the antianxiety effects of products containingCitrus aurantiumorCitrus sinensisEOs in combination with other active substances, including medicinal pla…
Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABAA Receptors
2011
Ethyl alcohol (ethanol) has many molecular targets in the nervous system, its potency at these sites being low compared with those of sedative drugs. This has made it difficult to discover ethanol’s binding site(s). There are two putative binding sites at gamma-aminobutyric acid (GABA) type A receptor subtypes for the proposed ethanol antagonist Ro 15-4513, the established gamma2 subunit-dependent benzodiazepine site and the recently reported delta subunit-dependent Ro 15-4513/ethanol binding site. Here, we aimed at clarifying the in vivo role of Ro 15-4513 at these two sites. We found that the antagonism of ethanol actions by Ro 15-4513 in wildtype mice was dependent on the test: an open f…
A double blind placebo-controlled study on the rectal administration of morphine as a premedication in abdominal hysterectomy
2000
Abstract Benzodiazepines are now commonly used as anxiolytic premedication prior to surgery. However, the role of opioids, as a premedication, has diminished over the last decades and they are no longer routinely used for premedication. Rather, opioids are generally used to treat severe pain in the postoperative period. Studies have shown that both NSAIDs and opioids improve analgesia in the early postoperative period. Until now, there have been no studies investigating the effect of morphine as a rectal premedication in adults in combination with blood levels of morphine. The effect of a rectal premedication with 30 mg of morphine sulphate, on postoperative pain levels and opioid consumpti…