Search results for "Aortic valve"

showing 10 items of 179 documents

Heart Valve Abnormalities in Systemic Sclerosis Patients; A Multicenter Cohort Study and Review of the Literature

2020

Background Systemic sclerosis (SSc) is a chronic autoimmune disease that is characterized by vasculopathy and fibrosis of the skin and visceral organs. Heart valve diseases are poorly described and generally not considered typical of SSc. We aimed to describe valvular abnormalities in a multicenter cohort of SSc patients and to investigate their correlation with SSc features. Methods We recruited 118 consecutive SSc patients (male/female, 14/104; mean age, 55.2 ± 12.1 years) in 3 rheumatology centers in Sicily, Italy, from January to October 2019. Results Mitral and tricuspid valve insufficiency was found in 85% and 91% of patients, respectively; regurgitations were generally mild and never…

Aortic valveAdultMalemedicine.medical_specialtyHeart Valve DiseasesTricuspid stenosisSclerodermaCohort Studies03 medical and health sciences0302 clinical medicineRheumatologyTricuspid Valve InsufficiencyMitralInternal medicineMedicineHumansMulticenter Studies as Topiccardiovascular diseases030212 general & internal medicineHeart valveAortic valveskin and connective tissue diseasesAged030203 arthritis & rheumatologyScleroderma Systemicintegumentary systembusiness.industrySystemicMitral Valve InsufficiencyMiddle Agedmedicine.diseaseValvular diseaseHeart ValvesRheumatologyTricuspid Valve InsufficiencyStenosismedicine.anatomical_structurePulmonary valvecardiovascular systemCardiologySystemic sclerosisFemalebusinessTricuspidCohort study
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Biomechanical study on ascending aortic aneurysms associated with quadricuspid aortic valve

2020

The quadricuspid aortic valve (QAV) is a rare anatomical situation and the biomechanical properties are not well known when it is associated with ascending aortic aneurysms (AsAA). The objective is to find out what is the biomechanical properties in such situation and to compare it with the existing data. In a sixty-three-years-old female (BMI 26,4) with hypertension disease, QAV, AsAA of 52 mm, an aortic valve and ascending aorta replacement were performed. The aortic wall sample was collected within 30 mins after replacement, partitioned related to medial, posterior, lateral, and anterior quadrants. The sample was cut in square size (15 mm × 15 mm, n = 13) with marking the circumferential…

Aortic valveAortic archAortabusiness.industryBiaxial tensile testAnatomy030204 cardiovascular system & hematologymedicine.disease03 medical and health sciencesQuadrant (abdomen)0302 clinical medicineBicuspid aortic valvemedicine.anatomical_structureQuadricuspid aortic valvemedicine.arteryAscending aortacardiovascular systemmedicine[INFO.INFO-IM]Computer Science [cs]/Medical Imaging030212 general & internal medicineCardiology and Cardiovascular MedicinebusinessComputingMilieux_MISCELLANEOUS
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Heart valve tissue engineering: how far is the bedside from the bench?

2015

Heart disease, including valve pathologies, is the leading cause of death worldwide. Despite the progress made thanks to improving transplantation techniques, a perfect valve substitute has not yet been developed: once a diseased valve is replaced with current technologies, the newly implanted valve still needs to be changed some time in the future. This situation is particularly dramatic in the case of children and young adults, because of the necessity of valve growth during the patient's life. Our review focuses on the current status of heart valve (HV) therapy and the challenges that must be solved in the development of new approaches based on tissue engineering. Scientists and physicia…

Aortic valveHeart diseaseSwine030204 cardiovascular system & hematology0302 clinical medicineHeart valve tissue engineeringHyaluronic AcidChildProsthetic valve0303 health sciencesMARROW-DERIVED CELLSTissue ScaffoldsFetal BloodHeart Valves3. Good healthmedicine.anatomical_structureHeart Valve ProsthesisCardiologyMolecular MedicineCollagenmedicine.medical_specialtyPULMONARY VALVEBONE-MARROWInduced Pluripotent Stem CellsVENTRICULAR OUTFLOW TRACTMESENCHYMAL STEM-CELLS03 medical and health sciencesTissue scaffoldsInternal medicineEXTRACELLULAR-MATRIXmedicineAnimalsHumansHeart valveIntensive care medicineENDOTHELIAL PROGENITOR CELLSMolecular Biology030304 developmental biologyBioprosthesisAORTIC-VALVEFibrinSheepTissue Engineeringbusiness.industryEndothelial Cellsmedicine.diseaseTransplantationPulmonary valveUMBILICAL-CORD BLOOD1182 Biochemistry cell and molecular biologybusinessHUMAN AMNIOTIC-FLUIDExpert Reviews in Molecular Medicine
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In Silico Shear and Intramural Stresses are Linked to Aortic Valve Morphology in Dilated Ascending Aorta

2017

Objective/Background: The development of ascending aortic dilatation in patients with bicuspid aortic valve (BAV) is highly variable, and this makes surgical decision strategies particularly challenging. The purpose of this study was to identify new predictors, other than the well established aortic size, that may help to stratify the risk of aortic dilatation in BAV patients.Methods: Using fluid-structure interaction analysis, both haemodynamic and structural parameters exerted on the ascending aortic wall of patients with either BAV ( n = 21) or tricuspid aortic valve (TAV; n = 13) with comparable age and aortic diameter (42.7 +/- 5.3 mm for BAV and 45.4 +/- 10.0 mm for TAV) were compared…

Aortic valveMalePatient-Specific ModelingComputed Tomography AngiographyHeart Valve DiseasesHemodynamics02 engineering and technology030204 cardiovascular system & hematology0302 clinical medicineBicuspid aortic valveBicuspid Aortic Valve DiseaseRisk FactorsAortaSinotubular JunctionModels CardiovascularSettore ING-IND/34 - Bioingegneria IndustrialeComputational modelingAneurysm of ascending aortaMiddle AgedAortic AneurysmHeart Valve Diseasemedicine.anatomical_structureAortic Valvecardiovascular systemCardiologyWall shear streFemaleCardiology and Cardiovascular MedicineBlood Flow VelocityDilatation PathologicHumanmedicine.medical_specialtyBicuspid aortic valve0206 medical engineeringAortography03 medical and health sciencesInternal medicinemedicine.arteryAscending aortamedicineHumansAgedAortabusiness.industryRisk FactorSignificant differenceHemodynamicsmedicine.disease020601 biomedical engineeringAortic wallRegional Blood FlowSurgeryStress Mechanicalbusiness
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Focus on the unique mechanisms involved in thoracic aortic aneurysm formation in bicuspid aortic valve versus tricuspid aortic valve patients: clinic…

2013

OBJECTIVES: The involvement of different factors in the onset of thoracic aortic aneurysm (TAA) in patients with a bicuspid aortic valve (BAV) vs those with a tricuspid aortic valve (TAV) is well recognized. However, the molecular, genetic and cellular mechanisms driving TAA remain unclear. The aim of this study was to identify the different mechanisms involved in TAA development in patients with BAV vs TAV. METHODS: Aorta specimens and DNA samples were collected from 24 BAV (18 men and 6 women; mean age: 54.2 ± 14.39 years) and 110 TAV (79 men and 31 women, mean age: 66 ± 9.8 years) patients. A control group of 128 subjects (61 men and 67 woman, mean age: 61.1 ± 5.8 years) was also enrolle…

Aortic valveMaleThoracicHeart Valve DiseasesApoptosisPilot ProjectsBicuspid aortic valve; Clinical implications; Identifying different genetic and histological profiles; Thoracic aortic aneurysm; Tricuspid aortic valve; Adult; Aged; Aortic Aneurysm Thoracic; Aortic Valve; Apoptosis; Comorbidity; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Valve Diseases; Histocytochemistry; Humans; Male; Matrix Metalloproteinase 9; Middle Aged; Pilot Projects; Polymorphism Single Nucleotide; Risk Factors; Tricuspid ValveComorbidityBicuspid aortic valveBicuspid Aortic Valve DiseaseGene FrequencyFibrosisRisk FactorsClinical implicationsTricuspid valvebiologyHistocytochemistryGeneral MedicineSingle NucleotideMiddle AgedAortic Aneurysmmedicine.anatomical_structureMatrix Metalloproteinase 9Aortic ValveCardiologyFemaleTricuspid ValveCardiology and Cardiovascular MedicinePulmonary and Respiratory MedicineAdultmedicine.medical_specialtyBicuspid aortic valveGenotypeThoracic aortic aneurysmTricuspid aortic valvePolymorphism Single Nucleotidemedicine.arteryInternal medicineThoracic aortic aneurysmAscending aortamedicineSettore MED/05 - Patologia ClinicaHumansGenetic Predisposition to DiseasePolymorphismIdentifying different genetic and histological profilesAgedAortaAortic Aneurysm Thoracicbusiness.industryAngiotensin-converting enzymeSettore MED/23 - Chirurgia Cardiacamedicine.diseasebiology.proteinSurgerybusinessEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
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Treatment of isolated ascending aortic aneurysm by off-pump epiaortic wrapping is safe and durable.

2016

OBJECTIVES: Isolated ascending aortic aneurysm (iAA) is usually treated by open graft repair requiring sternotomy, cardiopulmonary bypass (CPB) and cardioplegia. This approach carries significant mortality in older patients or those presenting with comorbidities. We report an original series of patients presenting with iAA and treated with epiaortic wrapping by using a synthetic mesh. This less invasive aortic repair technique allows reducing the aortic diameter to a predefined value and is performed without CPB. METHODS: Data from patients presenting with an iAA and treated with the wrapping technique (WT) by polypropylene/polyester mesh from November 2006 to July 2015 were collected. The …

Aortic valveMaleTime Factors030204 cardiovascular system & hematologySettore MED/22 - Chirurgia Vascolarelaw.inventionAortic aneurysm0302 clinical medicinelawAorta10042 Clinic for Diagnostic and Interventional RadiologyMedicine (all)Middle Aged2746 Surgerymedicine.anatomical_structureTreatment OutcomeWrapping girdlingFemaleCardiology and Cardiovascular MedicineVascular Surgical ProceduresPulmonary and Respiratory Medicinemedicine.medical_specialtyOffOff-pump610 Medicine & healthProsthesis Design2705 Cardiology and Cardiovascular MedicineGraft repair03 medical and health sciencesAneurysmBlood vessel prosthesismedicine.arteryAscending aortamedicineCardiopulmonary bypassHumansAortic valve insufficiency; Ascending aorta; Graft repair; Mesh (polypropylene/polyester); Off-pump; Wrapping girdling; Surgery; Medicine (all); Pulmonary and Respiratory Medicine; Cardiology and Cardiovascular MedicineAgedRetrospective StudiesAortaAortic Aneurysm Thoracicbusiness.industryPerioperativemedicine.diseaseSternotomySurgeryBlood Vessel Prosthesis030228 respiratory systemAortic valve insufficiency2740 Pulmonary and Respiratory MedicinepumpSurgeryAscending aortaMesh (polypropylene/polyester)businessFollow-Up StudiesInteractive cardiovascular and thoracic surgery
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Outcomes of aortic valve repair according to valve morphology and surgical techniques

2012

OBJECTIVES: The aim of this study was to assess the impact of aortic valve morphology and different surgical aortic valve repair techni- ques on long-term clinical outcomes. METHODS: Between February 2003 and May 2010, 216 patients with aortic insufficiency underwent aortic valve repair in our institu- tion. Ages ranged between 26 and 82 years (mean 53 ± 15 years). Aortic valve dysfunctions, according to functional classification, were: type I in 55 patients (25.5%), type II in 126 (58.3%) and type III in 35 (16.2%). Sixty-six patients (27.7%) had a bicuspid valve. Aortic valve repair techniques included sub-commissural plasty in 138 patients, plication in 84, free-edge reinforcement in 80,…

Aortic valveMaleTime Factorsmedicine.medical_treatmentKaplan-Meier EstimateAortic valve repairRecurrenceRisk FactorsMitral valve80 and overHospital MortalityCoronary Artery BypassAortaUltrasonographyAged 80 and overTricuspid valveCalcinosisCardiac Valve AnnuloplastyMiddle AgedAortic valve repair • Bicuspid aortic valve • Tricuspid aortic valve • Aortic annulus stabilization medicine.anatomical_structureTreatment OutcomeAortic ValveReplantationcardiovascular systemCardiologyChordae TendineaeMitral ValveFemaleChordae tendineaeCardiology and Cardiovascular MedicineAdult; Aged; Aged 80 and over; Aorta; Aortic Valve; Aortic Valve Insufficiency; Blood Vessel Prosthesis Implantation; Calcinosis; Chordae Tendineae; Coronary Artery Bypass; Disease-Free Survival; Female; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Mitral Valve; Proportional Hazards Models; Recurrence; Replantation; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography; Cardiac Valve Annuloplasty; Suture TechniquesPulmonary and Respiratory MedicineAdultmedicine.medical_specialtyAortic Valve InsufficiencyRisk AssessmentCardiac Valve AnnuloplastyDisease-Free SurvivalBlood Vessel Prosthesis ImplantationBicuspid valveInternal medicinemedicineHumansAgedProportional Hazards ModelsMitral valve repairbusiness.industrySuture TechniquesSettore MED/23 - Chirurgia CardiacaOriginal ArticlesSurgerySurgerybusiness
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A multicentre European registry to evaluate the Direct Flow Medical transcatheter aortic valve system for the treatment of patients with severe aorti…

2016

Aims Our aim was to assess the clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System (DFM-TAVS), when used in routine clinical practice. Methods and results This is a prospective, open-label, multicentre, post-market registry of patients treated with DFM-TAVS according to approved commercial indications. Echocardiographic and angiographic data were evaluated by an independent core laboratory and adverse events were adjudicated and classified according to VARC-2 criteria by an independent clinical events committee. The primary endpoint was freedom from all-cause mortality at 30 days post procedure. Secondary endpoints included procedural, early safety and efficacy en…

Aortic valveMalemedicine.medical_specialtyCardiac Catheterizationmedicine.medical_treatmentAortic Valve InsufficiencyRegurgitation (circulation)030204 cardiovascular system & hematologyTranscatheter Aortic Valve Replacement03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineClinical endpointHumans030212 general & internal medicineHeart valveProspective StudiesRegistriesCardiac catheterizationAgedAged 80 and overHeart Valve Prosthesis Implantationbusiness.industryAortic Valve Stenosismedicine.disease3. Good healthClinical trialStenosismedicine.anatomical_structureTreatment OutcomeAortic valve stenosisAortic ValveHeart Valve ProsthesisCardiologyFemaleCardiology and Cardiovascular MedicinebusinessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve.

2012

The aortic dissection (AoD) of an ascending thoracic aortic aneurysm (ATAA) initiates when the hemodynamic loads exerted on the aneurysmal wall overcome the adhesive forces holding the elastic layers together. Parallel coupled, two-way fluid–structure interaction (FSI) analyses were performed on patient-specific ATAAs obtained from patients with either bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) to evaluate hemodynamic predictors and wall stresses imparting aneurysm enlargement and AoD. Results showed a left-handed circumferential flow with slower-moving helical pattern in the aneurysm's center for BAV ATAAs whereas a slight deviation of the blood flow toward the anterolater…

Aortic valveMalemedicine.medical_specialtyFluid–structure interaction Aortic dissection Ascending thoracic aortic aneurysm Bicuspid aortic valveBiomedical EngineeringBiophysicsHeart Valve DiseasesAorta ThoracicThoracic aortic aneurysmArticleAortic aneurysmBicuspid aortic valveBicuspid Aortic Valve DiseaseInternal medicinemedicine.arteryCoronary CirculationAscending aortamedicineThoracic aortaHumansOrthopedics and Sports Medicinecardiovascular diseasesAgedAortic dissectionAortabusiness.industryRehabilitationHemodynamicsModels CardiovascularMiddle Agedmedicine.diseaseElasticityAortic Aneurysmmedicine.anatomical_structureAortic ValveCardiologycardiovascular systemFemaleTricuspid ValvebusinessJournal of biomechanics
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Value and limitations of transesophageal echocardiography in the evaluation of aortic prostheses.

1993

Results of 34 transesophageal (TEE) studies in patients with suspected aortic prosthetic dysfunction were compared with transthoracic echocardiographic (TTE) results and to anatomic findings. Mass lesions noted at surgery (autopsy) were correctly described in 93% by TEE versus 43% by TTE. Abscesses were detected in 88% by TEE versus 18% by TTE. Bioprosthetic degeneration was visualized in 88% versus 38% and prosthetic obstruction correctly identified in 75% versus 50% by TEE and TTE, respectively. Anatomic aortic regurgitant lesions were identified in 96% by TEE versus 77% by TTE, whereas the correct origin was detected in 88% of cases by TEE versus 54% of cases by TTE. TEE provides valuabl…

Aortic valveMalemedicine.medical_specialtyProsthesis-Related InfectionsAortic Valve InsufficiencyAutopsySensitivity and SpecificityPostoperative ComplicationsPredictive Value of TestsmedicineHumansRadiology Nuclear Medicine and imagingIn patientProspective StudiesBioprosthesisbusiness.industryThrombosisbody regionsmedicine.anatomical_structureEchocardiographyAortic ValveHeart Valve ProsthesisFemaleRadiologyCardiology and Cardiovascular Medicinebusinesshuman activitiesJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
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