Search results for "Application"
showing 10 items of 5559 documents
An Overview of Systematic Reviews of the Role of Vitamin D on Inflammation in Patients with Diabetes and the Potentiality of Its Application on Diabe…
2022
Almost two years have passed since the outbreak reported for the first time in Wuhan of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome (SARS)-CoV-2 coronavirus, rapidly evolved into a pandemic. This infectious disease has stressed global health care systems. The mortality rate is higher, particularly in elderly population and in patients with comorbidities such as hypertension, diabetes mellitus, cardiovascular disease, chronic lung disease, chronic renal disease, and malignancy. Among them, subjects with diabetes have a high risk of developing severe form of COVID-19 and show increased mortality. How diabetes contributes to COVID-19 severity remains unclear. …
The Role of Immunosenescence in Cerebral Small Vessel Disease: A Review.
2022
Cerebral small vessel disease (CSVD) is one of the most important causes of vascular dementia. Immunosenescence and inflammatory response, with the involvement of the cerebrovascular system, constitute the basis of this disease. Immunosenescence identifies a condition of deterioration of the immune organs and consequent dysregulation of the immune response caused by cellular senescence, which exposes older adults to a greater vulnerability. A low-grade chronic inflammation status also accompanies it without overt infections, an “inflammaging” condition. The correlation between immunosenescence and inflammaging is fundamental in understanding the pathogenesis of age-related CSVD (ArCSVD). Th…
Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation
2022
The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction…
Cellular and Molecular Signatures of Oxidative Stress in Bronchial Epithelial Cell Models Injured by Cigarette Smoke Extract
2022
Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). Increased oxidative stress leads to exhaustion of antioxidant defenses, alterations in autophagy/mitophagy and cell survival regulatory mechanisms, thus promoting cell senescence. All these events are amplified by the increase of inflammation driven by oxidative stress. Several models of bronchial epithelial cells are used to study the molec…
Gravitino dark matter with neutralino NLSP in the constrained NMSSM
2010
The gravitino dark matter with neutralino NLSP hypothesis is investigated in the framework of NMSSM. We have considered both the thermal and non-thermal gravitino production mechanisms, and we have taken into account all the collider and cosmological constraints. The maximum allowed reheating temperature after inflation, as well as the maximum allowed gravitino mass are determined.
MODIS-Based Monthly LST Products over Amazonia under Different Cloud Mask Schemes
2016
One of the major problems in the monitoring of tropical rainforests using satellite imagery is their persistent cloud coverage. The use of daily observations derived from high temporal resolution sensors, such as Moderate Resolution Imaging Spectroradiometer (MODIS), could potentially help to mitigate this issue, increasing the number of clear-sky observations. However, the cloud contamination effect should be removed from these results in order to provide a reliable description of these forests. In this study the available MODIS Land Surface Temperature (LST) products have been reprocessed over the Amazon Basin (10 N–20 S, 80 W–45 W) by introducing different cloud masking schemes. The mont…
Delay-dependent exponential stabilization of positive 2D switched state-delayed systems in the Roesser model
2014
This paper deals with the controller synthesis for a class of positive two-dimensional (2D) switched delay systems described by the Roesser model. This kind of systems has the property that the states take nonnegative values whenever the initial boundaries are nonnegative, some delay-dependent sufficient conditions for the exponential stability of positive 2D switched systems with state delays are given. Furthermore, the design of positive state feedback controller under which the resulting closed-loop system meets the requirements of positivity and exponential stability is presented in terms of linear matrix inequalities (LMIs). An example is included to illustrate the effectiveness of the…
Challenges in the Business Model of Low-Cost Airlines
2020
In recent decades, low-cost airlines have proliferated in the European market offering cheap tickets and increasing popularity. This business model, characterised by cost leadership, has been studied on numerous occasions. The case of the Irish airline Ryanair has presented different challenges over the last few years in relation to its stakeholders, who are shaping the sustainability of the current era of air travel. This business model should be adapted to the current demands of the market, such as corporate social responsibility or care for the environment. The functioning of low-cost airlines regarding the use they make of ERP management systems is also analysed. They aim to balance the…
Finding evidence on the innovative or positional character in medium sized manufacturing firms
2002
Through an empirically based study on 65 medium sized manufacturing firms corresponding to 12 industrial sectors and located in the Spanish region of Valencia, we seek in this paper to provide enough evidence about the prevalence of positional, static and myopic values or, instead, innovative, dynamic and open minded principles, among the firms under study. Gathered into three groups of sectors, depending on the scope of demand (weak, medium and strong demand sectors), we conclude that the weak and medium demand sectors are still facing remarkable challenges basically connected to technology issues, despite improvement in other variables directly linked to an innovative character.
Performance and energy optimisation in CPUs through fuzzy knowledge representation
2019
Abstract This paper presents an automatic design space exploration using processor design knowledge for the multi-objective optimisation of a superscalar microarchitecture enhanced with selective load value prediction (SLVP). We introduced new important SLVP parameters and determined their influence regarding performance, energy consumption, and thermal dissipation. We significantly enlarged initial processor design knowledge expressed through fuzzy rules and we analysed its role in the process of automatic design space exploration. The proposed fuzzy rules improve the diversity and quality of solutions, and the convergence speed of the design space exploration process. Experiments show tha…