Search results for "Application"
showing 10 items of 5559 documents
Natural Inhibitors of P-glycoprotein in AcuteMyeloid Leukemia
2023
Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms, and it is often caused by the overexpression of efflux pumps, the most important of which is P-glycoprotein (P-gp). This mini-review aims to examine the advantages of using natural substances as P-gp inhibitors, focusing on four molecules: phytol, curcumin, lupeol, and heptacosane, and their mechanism of action in AML.
Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome
2023
Multiple myeloma (MM) is a hematologic malignancy with a multistep evolutionary pattern, in which the pro-inflammatory and immunosuppressive microenvironment and genomic instability drive tumor evolution. MM microenvironment is rich in iron, released by pro-inflammatory cells from ferritin macromolecules, which contributes to ROS production and cellular damage. In this study, we showed that ferritin increases from indolent to active gammopathies and that patients with low serum ferritin had longer first line PFS (42.6 vs. 20.7 months and, p = 0.047, respectively) and OS (NR vs. 75.1 months and p = 0.029, respectively). Moreover, ferritin levels correlated with systemic inflammation markers …
Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway
2023
Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, vegetables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, and anticarcinogenic properties. Furthermore, they also have neuroprotective and cardioprotective effects. Their biological properties depend on the chemical structure of flavonoids, their mechanism of action, and their bioavailability. The beneficial effects of flavonoids have been proven for a variety of diseases. In the last few years, it is demonstrated that the effects of flavonoids are mediated by inhibiting the NF-κB (Nuclear Factor-κB) pathway. In this review, we have summar…
Photocatalytic Activity of TiO2 Coatings Obtained at Room Temperature on a Polymethyl Methacrylate Substrate
2022
Titanium dioxide (TiO2) coatings have a wide range of applications. Anatase exhibits hydrophilic, antimicrobial, and photocatalytic properties for the degradation of organic pollutants or water splitting. The main challenge is to obtain durable anatase nanoparticle coatings on plastic substrates by using straightforward approaches. In the present study, we revealed the preparation of a transparent TiO2 coating on polymethylmethacrylate (PMMA), widely used for organic optical fibres as well as other polymer substrates such as polypropylene (PP), polystyrene (PS), and polycarbonate (PC). The films were spin-coated at room temperature without annealing; therefore, our approach can be used for …
Enhancing performance of α‐diiminonickel precatalyst for ethylene polymerization by substitution with the 2,4‐bis(4,4'‐dimethoxybenzhydryl)‐6‐methylp…
2020
High activities in ethylene polymerization predetermine α‐diiminonickel precatalysts for potential industrial applications. In our study, we have synthesized and characterized a series of unsymmetrical 1‐(2,4‐bis(4,4′‐dimethoxybenzhydryl)‐6‐MeC6H2N)‐2‐arylimino‐acenaphthylene nickel(II) halides. The single‐crystal X‐ray diffraction study of representative compounds reveals distorted tetrahedral geometry. On activation with either Me2AlCl or modified methylaluminoxane, these nickel complexes exhibit high activities of the order of 106 g of PE (mol of Ni)−1 h−1 and produce polyethylene of generic application characterized by high molecular weight, narrow molecular weight distribution, and mod…
Applicability of the MASK-Air® App to Severe Asthma Treated with Biologic Molecules: A Pilot Study
2022
MASK-air®, a good practice of the DG Santé, has been fully validated in allergic rhinitis, but little is known about its applicability to asthmatics. We explored whether the MASK-air® application is applicable to patients with severe asthma. Severe asthmatics were proposed to use the MASK-air® application for 6 months, along with best practice treatment. Treatment of the patients was not changed based on the application results. The evolution of the visual analogue scales (VAS) for asthma, shortness of breath, rhinitis, conjunctivitis, work, and sleep was monitored using MASK-air®. Adherence to MASK-air® and to the asthma treatment was also checked. Thirteen patie…
Multiple Objective Analysis of Input-Output Models for Emergency Management
1990
This paper shows how a visual, interactive, dynamic multiple objective linear programming decision support system can effectively be used for analyzing input-output models. We have applied our approach to studying the quantitative effects of economic or political crises to the Finnish economy. Examples of such crises are nuclear power plant accidents, trade embargoes, and international conflicts. An input-output model of the Finnish economy with 17 industries (sectors) is employed. Our system has been implemented on a microcomputer and is being used by the National Board of Economic Defense. Several typical case situations are discussed.
Input-output feedback linearizing control of linear induction motor taking into consideration the end-effects. Part I: Theoretical analysis
2015
Abstract This first part of a paper, divided into two parts, deals with the theoretical formulation of the input–output feedback linearization (FL) control technique as to be applied to linear induction motors (LIMs). Linear induction motors, differently from rotating induction motors (RIMs), present other strong non-linearities caused by the so-called dynamic end effects, leading to a space-vector model with time-varying inductance and resistance terms and an additional braking force term. This paper, starting from a dynamic model of the LIM taking into consideration its dynamic end effects, previously developed by the same authors, defines a feedback linearization (FL) technique suited fo…
Input-Output Feedback Linearizing Control of Linear Induction Motor Taking into Consideration the End-Effects. Part II: Simulation and Experimental R…
2015
This is the second part of a paper, divided in two parts, dealing with the application of the input–output feedback linearization (FL) control technique to linear induction motors (LIMs). The first part has treated the theoretical formulation of the input–output feedback linearization control technique as to be applied to linear induction motors. This second part describes the set of tests, both in numerical simulations and experiments, performed to assess the validity of the control technique. In particular, it addresses the issues of the sensitivity of the FL control versus the LIM electrical parameters’ variations and the improvements achievable by considering the LIM dynamic end effects…
A robust forward-displacement analysis of spherical parallel robots
2009
The forward-displacement analysis of spherical parallel robots (SPRs) is revisited. A robust approach, based on the input–output (I/O) equation of spherical four-bar linkages, is proposed. In this approach, the closed-loop kinematic chain of a SPR is partitioned into two four-bar spherical chains, whose I/O equations are at the core of the analysis reported here. These equations lead to a trigonometric equation in the joint angles, which is solved semigraphically to obtain the joint variables for the determination of the moving plate orientation. Examples are included to demonstrate the application of the method.