Search results for "Apses"
showing 10 items of 193 documents
Projekts: Kokapstrādes uzņēmums SIA "ASP KZ"
2016
Maģistra darbs Projekts: „Kokapstrādes uzņēmums SIA „ASP KZ”” izstrādāts biznesa plāna formā, plānojot uzņēmuma dibināšanas kārtību, darbības principus, produktus, mārketinga aktivitātes, finanšu plānu un risku vadību. Maģistra darba mērķis ir izveidot ilgtspējīgu biznesa projektu – kokapstrādes uzņēmumu, kas specializēsies apses koka apstrādē, koksnes un koka izstrādājumu ražošana. Uzņēmuma pamatdarbība ir pirts un saunu apdares materiālu ražošana no apses (pirts un saunu sienu paneļi, lāvas dēļi un profilētas līstes). Apses koka dēļi ir nišas produkts, jo, neskatoties uz lielo kokapstrādes uzņēmumu skaitu Latvijā, apses dēļu ražošanā veiksmīgi specializējas tikai daži uzņēmumi. Konkurence…
Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice.
2007
The endocannabinoid system (ECS) possesses neuromodulatory functions by influencing the release of various neurotransmitters, including GABA, noradrenaline, dopamine, glutamate and acetylcholine. Even though there are studies indicating similar interactions between the ECS and the serotonergic system, there are no results showing clear evidence for type 1 cannabinoid receptor (CB1) location on serotonergic neurons. In this study, we show by in situ hybridization that a low but significant fraction of serotonergic neurons in the raphe nuclei of mice contains CB1 mRNA as illustrated by the coexpression with the serotonergic marker gene tryptophane hydroxylase 2, the rate limiting enzyme for t…
Usher syndrome: molecular links of pathogenesis, proteins and pathways.
2006
Contains fulltext : 50437.pdf (Publisher’s version ) (Closed access) Usher syndrome is the most common form of deaf-blindness. The syndrome is both clinically and genetically heterogeneous, and to date, eight causative genes have been identified. The proteins encoded by these genes are part of a dynamic protein complex that is present in hair cells of the inner ear and in photoreceptor cells of the retina. The localization of the Usher proteins and the phenotype in animal models indicate that the Usher protein complex is essential in the morphogenesis of the stereocilia bundle in hair cells and in the calycal processes of photoreceptor cells. In addition, the Usher proteins are important in…
Pineal 'synaptic' ribbon numbers and melatonin synthesis of rat are resistant to guanethidine sympathectomy.
1995
Chemical sympathectomy is widely used to study the impact of the noradrenergic system on neuronal and neuroendocrine circuits. We tested the effects of intraperitoneal injections of guanethidine, an adrenergic neuron blocking agent, on selected functional parameters of the rat pineal gland which are known to be under sympathetic influence. The reliability of the method was demonstrated by the clear enophthalmus developed by experimental animals. However, neither the numbers of 'synaptic' ribbons nor melatonin synthesis differed between treated and control rats, both parameters exhibiting the nocturnal increase seen in intact animals. These results are in striking contrast to those obtained …
Zinc-positive boutons in the cerebral cortex of lizards show glutamate immunoreactivity
1991
Zinc-positive boutons, originating in the medial cortex of lizards, exhibit glutamate immunoreactivity. This finding supports the presumed homology between lizard zinc-positive boutons and the hippocampal mossy fibres of mammals, which are also glutamate-immunoreactive and zinc-positive. Zinc-positive boutons of lizards contain a chelatable pool of zinc located in the hippocampal mossy fibres of mammals. These synaptic systems also contain glutamate, which indicates a possible simultaneous action of zinc and glutamate during synaptic transmission.
Cytoskeletal stabilization of inhibitory interactions in immunologic synapses of mature human dendritic cells with natural killer cells
2011
Abstract Human mature dendritic cells (DCs) can efficiently stimulate natural killer (NK)–cell responses without being targeted by their cytotoxicity. To understand this important regulatory crosstalk, we characterized the development of the immunologic synapse between mature DCs and resting NK cells. Conjugates between these 2 innate leukocyte populations formed rapidly, persisted for prolonged time periods and matured with DC-derived f-actin polymerization at the synapse. Polarization of IL-12 and IL-12R to the synapse coincided with f-actin polymerization, while other activating and inhibitory molecules were enriched at the interface between DCs and NK cells earlier. Functional assays re…
Lapsen hyvinvointi ja osallisuus lastensuojelun läheisneuvonpidon dokumenteissa
2014
Tämän laadullisen tutkimuksen kohteena ovat lastensuojelun dokumentit. Tutkimustehtävänä on kuvata ja ymmärtää lapsen hyvinvointia ja osallisuutta lastensuojelun läheisneuvonpidossa asiakirjojen perusteella. Tutkimuksessa on mukana 15 lapsen läheisneuvonpidon dokumentit, jotka koskevat 2 -17 vuotiaita lapsia. Tutkimuksen aineistoa analysoin sisällönanalyysimenetelmän avulla. Tutkimuksen teoreettisena pohjana ovat käsitykset lapsesta, lapsen hyvinvoinnista ja osallisuudesta. Tutkin lasten hyvinvointia tarkastelemalla lasten vanhempien elämäntilannetta. Havaitsin vanhempien elämäntilanteessa esiintyvän samanaikaisesti haasteita usealla elämän osa-alueella. Lasten hyvinvointia tutkin lasten hy…
eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1.
2017
The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C-¿ (PKC-¿) at the central supramolecular activation cluster (c-SMAC) of the IS. eNOS translocated with the Golgi to the IS and partially colocalized with F-actin around the c-SMAC. This resulted in reduced actin polymerization and centripetal retrograde flow of ß-actin and PKC-¿ from the lamellipodium-like distal (d)-SMAC, promoting PKC-¿ activation. Furthermore, eNOS-derived NO S-nitrosylated ß-…
Cannabinoid CB1 Receptor Calibrates Excitatory Synaptic Balance in the Mouse Hippocampus
2015
The endocannabinoid system negatively regulates the release of various neurotransmitters in an activity-dependent manner, thereby influencing the excitability of neuronal circuits. In the hippocampus, cannabinoid type 1 (CB1) receptor is present on both GABAergic and glutamatergic axon terminals. CB1 receptor-deficient mice were previously shown to have increased hippocampal long-term potentiation (LTP). In this study, we have investigated the consequences of cell-type-specific deletion of the CB1 receptor on the induction of hippocampal LTP and on CA1 pyramidal cell morphology. Deletion of CB1 receptor in GABAergic neurons in GABA-CB1-KO mice leads to a significantly decreased hippocampal …
TLR4 elimination prevents synaptic and myelin alterations and long-term cognitive dysfunctions in adolescent mice with intermittent ethanol treatment.
2015
The adolescent brain undergoes important dynamic and plastic cell changes, including overproduction of axons and synapses, followed by rapid pruning along with ongoing axon myelination. These developmental changes make the adolescent brain particularly vulnerable to neurotoxic and behavioral effects of alcohol. Although the mechanisms of these effects are largely unknown, we demonstrated that ethanol by activating innate immune receptors toll-like receptor 4 (TLR4), induces neuroinflammation and brain damage in adult mice. The present study aims to evaluate whether intermittent ethanol treatment in adolescence promotes TLR4-dependent pro-inflammatory processes, leading to myelin and synapti…