Search results for "Arabinonucleotides"

showing 2 items of 2 documents

Differential mode of inhibition of terminal deoxynucleotidyl transferase by 3′-dATP, ATP, βaraATP and αaraATP

1978

TUNEL assayArabinonucleotidesChemistryBiophysicsThymus GlandCell BiologyBiochemistryMolecular biologyStructure-Activity RelationshipAdenosine TriphosphateDeoxyadenine NucleotidesTerminal deoxynucleotidyl transferaseDNA NucleotidylexotransferaseStructural BiologyDNA NucleotidyltransferasesGeneticsAnimalsCattleMolecular BiologyDifferential (mathematics)FEBS Letters
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Inhibition of the herpes simplex virus-coded thymidine kinase-complex by 9-?-D-arabinofuranosyladenine 5?-monophosphate (ara-AMP) and 9-(2-hydroxyeth…

1984

The thymidine kinase-complex isolated from herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) is associated with the following enzyme activities: ATP:dThd (dCyd) deoxypyrimidine kinase, ATP:dTMP thymidylate kinase, ADP:dThd- and AMP:dThd5′-phosphotransferase. In kinetic experiments it is shown that ara-AMP inhibits AMP:dThd- and ADP:dThd phosphotransferase activity, while acyclo-GMP impairs ADP:dThd phosphotransferase reaction only; the inhibition was found to be non-compertitive. The functional subunit ATP:dThd kinase was not affected by either compound.

chemistry.chemical_classificationArabinonucleotidesGuanineKinaseAcyclovirGeneral MedicineBiologyThymidine KinaseThymidylate kinaseVirologyMolecular biologyPhosphotransferaseKineticschemistry.chemical_compoundEnzymechemistryBiochemistryMultienzyme ComplexesThymidine kinaseVirologySimplexvirusNucleotideThymidineVidarabine PhosphateArchives of Virology
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