Search results for "Arenes"
showing 10 items of 622 documents
In the first person: Avicenna’s concept of self-awarenessreconstructed
2015
THE DEVELOPMENT OF A QUESTIONNAIRE ON METACOGNITION FOR STUDENTS IN SECONDARY SCHOOL
2014
Interest in the role of metacognition has been steadily rising in most forms of education. The present paper focuses on the construction of a questionnaire for measuring metacognitive knowledge, metacognitive regulation and metacognitive responsiveness among Secondary school students and the subsequent process of testing to determine its validity. The questionnaire was administered to 4119 students, (230 school classes) in various types of schools in Palermo, Italy. The general aim of the study was to reveal the effects of teaching specific learning strategies to students on their metacognitive knowledge, their use of metacognitive skills, and their success. The data gathered were analyzed …
Metacognitive Awareness Teaching Tool Kit (MATTK). Reflective teaching for critical thinking and creativity development in classroom.
2016
Situation awareness has long been recognized as an important variable in teacher performance. Research to date has focused on identifying characteristics of situation awareness for individuals, not on the behaviors and processes associated with situation awareness. The purpose of this review is to delineate and identify characteristics of teacher metacognitive awareness. In addition, implications are discussed and research questions are outlined that target the measurement and training of situation awareness. The research has examined the positive correlation between the meta cognitive awareness of teachers and the development of two soft skills (critical thinking and creativity) in student…
Enseñar Mindfulness: Contextos de Instrucción y Pedagogía
2016
La aparición de mindfulness y su rápida diseminación en entornos clínicos obedece a diversas razones, siendo una de las más relevantes la relacionada con la pedagogía. La literatura científica ha propuesto un modelo de enseñanza de mindfulness basado en los mecanismos de eficacia, la configuración de nuevas demandas, y la aparición de diferentes contextos. El objetivo de este artículo es revisar por un lado los diferentes contextos de enseñanza de mindfulness (psicoeducativos, clínicos y espirituales), analizando las semejanzas y diferencias. A continuación se revisarán los mecanismos de eficacia (regulación de la atención, conciencia corporal, regulación emocional y cambios en la perspect…
Size- and Structure-Selective Noncovalent Recognition of Saccharides by Tetraethyl and Tetraphenyl Resorcinarenes in the Gas Phase
2008
The noncovalent complexation of tetraethyl and tetraphenyl resorcinarenes with mono-, di-, and oligosaccharides was studied with negative-polarization electrospray ionization quadrupole ion trap and electrospray ionization Fourier-transform ion cyclotron resonance mass-spectrometric analysis. The saccharides formed 1:1 complexes with deprotonated resorcinarenes, which exhibited clear size and structure selectivity in their complexation. In the case of the monosaccharides, hexoses formed much more abundant and kinetically stable complexes than pentoses or deoxyhexoses. A comparison of the mono-, di-, and oligosaccharides revealed that both the relative abundance and stability of the complexe…
Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene
2013
Cholera toxin (CT), the causative agent of cholera, displays a pentavalent binding domain that targets the oligosaccharide of ganglioside GM1 (GM1os) on the periphery of human abdominal epithelial cells. Here, we report the first GM1os-based CT inhibitor that matches the valency of the CT binding domain (CTB). This pentavalent inhibitor contains five GM1os moieties linked to a calix[5]arene scaffold. When evaluated by an inhibition assay, it achieved a picomolar inhibition potency (IC50 = 450 pM) for CTB. This represents a significant multivalency effect, with a relative inhibitory potency of 100000 compared to a monovalent GM1os derivative, making GM1os-calix[5]arene one of the most potent…
Piperazine bridged resorcinarene cages.
2010
The one-pot Mannich condensation of resorcinarenes with piperazine and an excess of formaldehyde under high dilution conditions results in a helical cage, namely, a covalently linked dimer of two resorcinarenes connected via four piperazine bridges in yields ranging from 20 to 40%. The compounds were analyzed by NMR spectroscopy, ESI mass spectrometry, and single crystal X-ray diffraction. The helical cages can encapsulate small guest molecules by adapting the cavity volume by changing the helical pitch according to the guest size.
Selective recognition of neutral guests in an aqueous medium by a biomimetic calix[6]cryptamide receptor
2015
The design of artificial receptors that can efficiently work in water is a challenging research area. A possible biomimetic approach for the elaboration of such receptors consists of associating a hydrophobic cavity with a polar polyfunctional binding site. On this basis, a hydrophilic calix[6]cryptamide decorated with oligo(ethylene glycol) units (i.e. 8) was synthesized through an efficient [1 + 1] macrocyclization reaction as the key-step. The complexation of neutral molecules was evaluated by NMR spectroscopy through competition experiments either in apolar or aqueous media. In both media, host 8 can bind neutral species that display H-bonding acceptor and donor groups such as amides or…
Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers.
2014
This communication demonstrates the possibility to nucleate and grow different crystalline polymorphic forms of gabapentin (GBP) using, as nucleation templates, Langmuir monolayers of an amphiphilic calixarene at different packing densities.
Mechanically interlocked calix[4]arene dimers display reversible bond breakage under force.
2009
The physics of nanoscopic systems is strongly governed by thermal fluctuations that produce significant deviations from the behaviour of large ensembles1,2. Stretching experiments of single molecules offer a unique way to study fundamental theories of statistical mechanics, as recently shown for the unzipping of RNA hairpins3. Here, we report a molecular design based on oligo calix[4]arene catenanes—calixarene dimers held together by 16 hydrogen bridges—in which loops within the molecules limit how far the calixarene nanocapsules can be separated. This mechanically locked structure tunes the energy landscape of dimers, thus permitting the reversible rupture and rejoining of the individual n…