6533b7d5fe1ef96bd126528f

RESEARCH PRODUCT

Polymorphism control of an active pharmaceutical ingredient beneath calixarene-based Langmuir monolayers.

Markus NeuburgerNegar MoridiPatrick ShahgaldianKaisa HelttunenLudovico G. TulliWenjie WangWolfgang MeierDavid Vaknin

subject

Models MolecularLangmuirCyclohexanecarboxylic AcidsNucleation02 engineering and technology010402 general chemistry01 natural sciencesCatalysisAmphiphileCalixareneMonolayerMaterials ChemistryOrganic chemistryAminesta116gamma-Aminobutyric AcidActive ingredientMolecular StructureChemistryMetals and AlloysGeneral Chemistry021001 nanoscience & nanotechnology0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsChemical engineeringPolymorphism (materials science)Pharmaceutical PreparationsCeramics and CompositesCalixarenesGabapentin0210 nano-technology

description

This communication demonstrates the possibility to nucleate and grow different crystalline polymorphic forms of gabapentin (GBP) using, as nucleation templates, Langmuir monolayers of an amphiphilic calixarene at different packing densities.

yearjournalcountryeditionlanguage
2014-03-07Chemical communications (Cambridge, England)
10.1039/c4cc00928bhttps://pubmed.ncbi.nlm.nih.gov/24599407