Search results for "Argo"
showing 10 items of 424 documents
Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonicDrosophilabrain
2016
The specification of distinct neural cell types in central nervous system development crucially depends on positional cues conferred to neural stem cells in the neuroectoderm. Here, we investigate the regulation and function of the epidermal growth factor receptor (EGFR) signalling pathway in early development of theDrosophilabrain. We find that localized EGFR signalling in the brain neuroectoderm relies on a neuromere-specific deployment of activating (Spitz, Vein) and inhibiting (Argos) ligands. Activated EGFR controls the spatially restricted expression of all dorsoventral (DV) patterning genes in a gene- and neuromere-specific manner. Further, we reveal a novel role of DV genes—ventral …
Function and Evolution of Nematode RNAi Pathways
2019
Selfish genetic elements, like transposable elements or viruses, are a threat to genomic stability. A variety of processes, including small RNA-based RNA interference (RNAi)-like pathways, has evolved to counteract these elements. Amongst these, endogenous small interfering RNA and Piwi-interacting RNA (piRNA) pathways were implicated in silencing selfish genetic elements in a variety of organisms. Nematodes have several incredibly specialized, rapidly evolving endogenous RNAi-like pathways serving such purposes. Here, we review recent research regarding the RNAi-like pathways of Caenorhabditis elegans as well as those of other nematodes, to provide an evolutionary perspective. We argue tha…
PIWIL3 Forms a Complex with TDRKH in Mammalian Oocytes.
2019
P-element induced wimpy testis (PIWIs) are crucial guardians of genome integrity, particularly in germ cells. While mammalian PIWIs have been primarily studied in mouse and rat, a homologue for the human PIWIL3 gene is absent in the Muridae family, and hence the unique function of PIWIL3 in germ cells cannot be effectively modeled by mouse knockouts. Herein, we investigated the expression, distribution, and interaction of PIWIL3 in bovine oocytes. We localized PIWIL3 to mitochondria, and demonstrated that PIWIL3 expression is stringently controlled both spatially and temporally before and after fertilization. Moreover, we identified PIWIL3 in a mitochondrial-recruited three-membered complex…
Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis
2017
Piwi-interacting RNAs (piRNAs) are 26–30-nucleotide germ line-specific small non-coding RNAs that have evolutionarily conserved function in mobile genetic element (transposons) silencing and maintenance of genome integrity. Drosophila Hsp70/90-organizing protein homolog (Hop), a co-chaperone, interacts with piRNA-binding protein Piwi and mediates silencing of phenotypic variations. However, it is not known whether Hop has a direct role in piRNA biogenesis and transposon silencing. Here, we show that knockdown of Hop in the germ line nurse cells (GLKD) of Drosophila ovaries leads to activation of transposons. Hop GLKD females can lay eggs at the same rate as wild-type counterparts, but the e…
‘He is Quirky; He is the World's Greatest Psychologist’: On the Community of Those Who Have Nothing in Common
2016
In this article, we challenge the concept of the therapeutic relationship as an operationalisable entity. In contrast to this idea, we introduce Alphonso Lingis’ concept of community, and his distinction between the rational community and the community of those who have nothing in common. This is done through speculative analysis of a transcribed sequence from a research interview with a boy who speaks about his experiences of receiving mental health care. This boy and his family were helped through a network-oriented, dialogical approach. In the sequence highlighted here, the boy speaks of the significance of a particular mental health practitioner. The boy expresses appreciation for the h…
Decay of48-50Ar isotopes
2011
International audience; Information on β-decay properties of neutron-rich 84-05Ar was obtained at the ISOLDE mass-separator facility at CERN using isobaric selectivity. This was achieved by a combination of a plasma-ion source with a cooled transfer line and subsequent mass-separation. Normally, argon beams cannot be mass-separated from intense multi-charged symmetric fission krypton and xenon. Several techniques were used successfully in order to overcome this problem. Implication of the obtained information for a better understanding of the origin of the 48Ca/46Ca isotopic anomaly discovered in inclusions from the Allende meteorite is discussed.
Ciudadanía de la familia y derecho-deber educativo de los padres
2021
El hombre no se define solo por su autonomía sino más bien por su relacionalidad, que se inicia con la filiación. A través de la tarea educativa los padres sostienen la libertad de los hijos en el camino de la vida, acompañándolos así hasta el cumplimiento de sus personas. La educación tiene como tarea propia la madurez personal, es decir, todo aquello que permite a una persona dirigir su vida en su globalidad, que se haga cargo de los elementos fundamentales que implica y a los que debe responder.
Un aspecto de la polémica gongorina: la lengua de las Soledades y el Polifemo como discutido criterio de corrección
2008
22 p. Maquieira Rodríguez, Marina A.. Un aspecto de la polémica gongorina: la lengua de las Soledades y el Polifemo como discutido criterio de corrección. En: Quaderns de filologia. Estudis lingüístics, 2008, No. 13. Dedicado a: Historiografía lingüística hispánica: 135 SI
Variables predictoras de la satisfacción con la vida en personas mayores que participan en programas formales de aprendizaje
2017
Este estudio tiene como objetivo conocer la relación entre diferentes variables demográficas y el bienestar y satisfacción con la vida, y evaluar la capacidad predictora de la satisfacción con la vida en una muestra de personas mayores que participan en el Programa Universitario para Personas Mayores de la Universidad de Valencia. La OMS define envejecimiento activo y sano como el proceso de optimizar oportunidades para la salud y la participación. El modelo de envejecimiento exitoso propone el compromiso activo con la vida, a través del mantenimiento de relaciones interpersonales y de las actividades productivas. El aprendizaje en la vejez tiene un impacto positivo en el envejecimiento. Un…
Accidente de Trabajo y Recargo
2015
En la actualidad existen diferentes formas de Accidente de Trabajo. En el presente trabajo se da a conocer las distintas formas y la doctrina de los tribunales. Se aborda el recargo de prestaciones de Seguridad Social y el deber del empresario en cumplir la normativa de Seguridad Social