Search results for "Argon"

Proterozoic dykes of Salvador and Ilhéus-Olivença areas: a geological geoghemical comparison

1991

Facebookland: o mundo bizarro-linguístico

2019

Abstract This article investigates the dynamics of contemporary Romanian, focusing on various linguistic structures typically used on social network sites, through which the specific content and interaction strategies are being deployed in virtual communities. The article is part of a larger project devoted to the study of linguistic impoverishment (affecting both the vocabulary and the grammatical structure of the language), social networks being only one of the areas where these “uglified” linguistic structures come from: the mass-media (both print and broadcast), advertising (outdoor, indoor, television commercials), Internet forums, corporate jargon, etc. The structures under scrutiny a…

Aukso vilna ir auksavilnis avinas: antikinių literatūros šaltinių liudijimai ir interpretacija

2018

The Golden Fleece figures in Greek mythology as the objective of the voyage of the Argonauts. The incompatability of the object of the search with the effort invested in its acquisition has furthered discussion of the real meaning of the Golden Fleece, which has generally been accepted to be a metaphor since antiquity. Modernity, especially at the turn of the 19th and 20th centuries, has been productive and inventive in the decipherment attempts of the metaphor’s hidden meaning. A number of interpretation theories has been developed, which, though interesting and wellargumented, are sometimes highly divergent from the interpretation of the Golden Fleece in the ancient sources. A proper unde…

Mini-laparoscopy in the endoscopy unit: Safety and outcomes in over one thousand patients

2011

AIM: To investigate the safety of consecutive mini-laparoscopy guided liver biopsies for the diagnosis and staging of liver diseases. METHODS: In this study we retrospectively analyzed the safety of mini-laparoscopic liver biopsy performed in an endoscopy unit in 1071 patients. We measured the incidence of bleeding and evaluated the management and outcome of bleeding interventions. RESULTS: The most common etiologies of liver injury were viral hepatitis and autoimmune liver disease. 250 patients had macroscopically and histologically proven cirrhosis. 13 patients had no pathological findings. 33% of all patients had bleeding that required argon plasma coagulation of the puncture site during…

Piwi Proteins and piRNAs in Mammalian Oocytes and Early Embryos

2015

SummaryGerm cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi and piRNA expression in oocytes of other mammals. Human fetal oocytes express PIWIL2 and transposon-enriched piRNAs. Oocytes in adult human ovary express PIWIL1 and PIWIL2, whereas those in bovine ovary only express PIWIL1. In human, macaque, and bovine ovaries, we find piRNAs that resemble testis-borne pachytene piRNAs. Isolated bovine follicular oocytes were shown to contain abundant, relatively short piRNAs that preferentially target transposable elements. Using label-free quantitative pr…

Tupaia small RNAs provide insights into function and evolution of RNAi-based transposon defense in mammals

2015

Argonaute proteins comprising Piwi-like and Argonaute-like proteins and their guiding small RNAs combat mobile DNA on the transcriptional and post-transcriptional level. While Piwi-like proteins and associated piRNAs are generally restricted to the germline, Argonaute-like proteins and siRNAs have been linked with transposon control in the germline as well as in the soma. Intriguingly, evolution has realized distinct Argonaute subfunctionalization patterns in different species but our knowledge about mammalian RNA interference pathways relies mainly on findings from the mouse model. However, mice differ from other mammals by absence of functional Piwil3 and expression of an oocyte-specific …

“My Mind Is Doing It All”

2015

Objective: To study whether pressure of speech in jargon aphasia arises out of disturbances to core language or executive processes, or at the intersection of conceptual preparation. Background: Conceptual preparation mechanisms for speech have not been well studied. Several mechanisms have been proposed for jargon aphasia, a fluent, well-articulated, logorrheic propositional speech that is almost incomprehensible. Methods: We studied the vast quantity of jargon speech produced by patient J.A., who had suffered an infarct after the clipping of a middle cerebral artery aneurysm. We gave J.A. baseline cognitive tests and experimental word-and sentencegeneration tasks that we had designed for …

Direct transnasal cholangioscopy with ultraslim endoscopes: a one-step intraductal balloon-guided approach.

2011

Background Direct cholangioscopy using an ultraslim endoscope is an attractive alternative to the conventional mother–baby endoscope system because it provides a single-operator platform and high-resolution image quality and allows advanced therapeutic interventions. However, biliary access is cumbersome and usually requires previous guidewire placement via retrograde cholangiography. Objective To evaluate the feasibility of a 1-step transnasal cholangioscopy (TNC) technique using an ultraslim endoscope with an intraductal balloon to maintain access without previous guidewire placement. Design Prospective, observational clinical feasibility study. Setting Single tertiary referral center. Ma…

Long-term Efficacy and Safety of Endoscopic Resection for Patients With Mucosal Adenocarcinoma of the Esophagus

2013

Background & Aims Barrett's esophagus–associated high-grade dysplasia is commonly treated by endoscopy. However, most guidelines offer no recommendations for endoscopic treatment of mucosal adenocarcinoma of the esophagus (mAC). We investigated the efficacy and safety of endoscopic resection in a large series of patients with mAC. Methods We collected data from 1000 consecutive patients (mean age, 69.1 ± 10.7 years; 861 men) with mAC (481 with short-segment and 519 with long-segment Barrett's esophagus) who presented at a tertiary care center from October 1996 to September 2010. Patients with low-grade and high-grade dysplasia and submucosal or more advanced cancer were excluded. All patien…

Roles of the Core Components of the Mammalian miRISC in Chromatin Biology

2022

The Argonaute (AGO) and the Trinucleotide Repeat Containing 6 (TNRC6) family proteins are the core components of the mammalian microRNA-induced silencing complex (miRISC), the machinery that mediates microRNA function in the cytoplasm. The cytoplasmic miRISC-mediated post-transcriptional gene repression has been established as the canonical mechanism through which AGO and TNRC6 proteins operate. However, growing evidence points towards an additional mechanism through which AGO and TNRC6 regulate gene expression in the nucleus. While several mechanisms through which miRISC components function in the nucleus have been described, in this review we aim to summarize the major findings that have …