Search results for "Arm"
showing 10 items of 19046 documents
Inhibidores atípicos del transporte de dopamina: posibles agentes terapéuticos para el tratamiento de la adicción a los estimulantes
2013
La adicción a psicoestimulantes es en la actualidad un fenómeno de gran importancia tanto desde el punto de vista clínico como social. Las consecuencias negativas que se derivan del consumo de estas sustancias son significativas, incluyendo problemas médicos, psicosociales y laborales. Asimismo el abuso de drogas se relaciona con tasas incrementadas de crimen y violencia. Según el último informe emitido por el Observatorio Europeo de las Drogas y Toxicomanías, el consumo de anfetaminas se ha mantenido estable en la mayoría de los países de la Unión Europea, mientras que el nivel de consumo de cocaína durante este último año se encuentra por encima de la media en países como Irlanda, Chipre,…
Calidad de la farmacoterapia antidiabética en el departamento de salud Valencia Clínico Malvarrosa en 2015-2019 con datos de la vida real
2023
La diabetes mellitus (DM) es una enfermedad crónica caracterizada por un déficit de insulina o de su acción, produciéndose, en ausencia de tratamiento, una elevación de la glucemia. La diabetes mellitus, especialmente del tipo 2 (DM2), se ha convertido en un problema de Salud Pública de primer nivel. Se trata de una enfermedad con una alta prevalencia y a que constituye un factor de riesgo para el sistema circulatorio , que además es previsible que se incremente con el aumento de esperanza de vida y el envejecimiento poblacional. Aunque el inicio del tratamiento farmacológico de la diabetes se inició básicamente en 1921 con el aislamiento de una sustancia insulínica, es en los últimos años …
Medyczne i religijne aspekty dbałości o bezpieczeństwo oraz dobrą kondycję wojsk bizantyjskich w świetle "Taktikonu" Leona VI
2017
Byzantine army in X century was one of the most complex and largest military machines in medieval history. Emperors and chieftains commanding this force had to care not only for the outcome of battles but also, and perhaps most importantly, for good condition and safety of the troops. Byzantine soldiers were expensive to train and equip so any losses would be harmful for the Empire, therefore some Emperors, Leo VI among them, created military treatises, that were basically handbooks for the Imperial army — fuli of regulations and recipes that would help commanders to lead and care for the army. Among many problems that treatises touched, two most important ones were conditions of health and…
Semi-natural habitats in boreal Europe: a rise of a social-ecological research agenda
2021
The European continent contains substantial areas of semi-natural habitats, mostly grasslands, which are among the most endangered habitats in Europe. Their continued existence depends on some form of human activity, for either production or conservation purposes, or both. We examined the share of semi-natural grasslands within the general grassland areas in boreal Europe. We reviewed research literature across the region to compile evidence on semi-natural grasslands and other semi-natural habitats, such as wooded pastures, in respect to a range of topics such as ecology, land-use change, socioeconomics, and production. We also explored drivers of the research agenda and outlined future re…
Synthesis and biological evaluation of the antioxidant properties of new analogues of natural products with piperidine based structure and evaluation…
Dažādu antidepresantu lietošanas izplatības salīdzinājums aptiekā
2015
Depresija ir viena no visbiežāk sastopamajām psihiskajām saslimšanām. Depresija izraisa būtiskus psihisko procesu traucējumus - nomāktu garastāvokli, domu gausumu, koncentrēšanās grūtības, dzīvesprieka zudumu u.c. Depresija skar aizvien vairāk cilvēkus darbspējas vecumā. Depresijas pacientiem ir augstāks risks saslimt ar kādu no somātiskām slimībām, piemēram cukura diabētu, koronāro sirds slimību. Šobrīd depresijas un depresīvu stāvokļu ārstēšanai tiek nozīmētas vairākas antidepresantu grupas, populārākās no tām ir serotonīna atpakaļsaistīšanas inhibitori, tricikliskie un atipiskie antidepresanti. Lai salīdzinātu dažādu antidepresantu lietošanas izplatību, par maģistra darba mērķi tika izvi…
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…
Antiagregantu un antikoagulantu aprite aptiekās četros Latvijas reģionos laika periodā 2013.-2015. gads
2017
Trombam nosprostojot asinsvadus, var rastiem nopietnas, dzīvībai bīstamas saslimšanas: miokarda infarkts, insults, dziļo vēnu tromboze vai plaušu embolija. Maģistra darbā ir apkopota informācija par realizētajiem antitrombotiskajiem līdzekļiem (antikoagulantiem un antiagregantiem) 4 aptiekās, kuras atrodas dažādās pilsētās – Rīgā, Jelgavā, Daugavpilī un Liepājā. Patēriņa dati tika salīdzināti pēc DDD/1000 iedzīvotājiem/dienā. Rēķinot pēc DDD/1000 iedzīvotājiem/dienā, rezultāti parāda to, ka visās 4 aptiekās lielāks pieprasījums ir pēc antiagregantiem nekā antikoagulantiem. Rezultātos var redzēt arī to, ka vislielākais antitrombotisko medikamentu patēriņš ir Rīgas aptiekā, savukārt vismazāk …
Economic and Life Cycle Analysis of Passive and Active Monitoring of Ozone for Forest Protection
2021
At forest sites, phytotoxic tropospheric ozone (O3) can be monitored with continuously operating, active monitors (AM) or passive, cumulative samplers (PM). For the first time, we present evidence that the sustainability of active monitoring is better than that of passive sensors, as the environmental, economic, and social costs are usually lower in the former than in the latter. By using data collected in the field, environmental, social, and economic costs were analyzed. The study considered monitoring sites at three distances from a control station in Italy (30, 400, and 750 km), two forest types (deciduous and Mediterranean evergreen), and three time windows (5, 10, and 20 years of moni…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…