Search results for "Arman"
showing 10 items of 51 documents
Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population
2010
BackgroundAlbeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis.Methodology/principal findingsImmunoproteasomes and PA28-alphabeta regulator are present in MS affected brain area and accumulated in plaques. They are expressed in cell types supposed to be involved in MS development such as neurons, endothelial cells, oligodendroc…
Diagnostic Value of Optical Spectral Transmission in Rheumatoid Arthritis: Associations with Clinical Characteristics and Comparison with Joint Ultra…
2020
Objective.To examine the value of optical spectral transmission (OST) in detecting joint inflammation in patients with rheumatoid arthritis (RA) and to evaluate whether OST correlates with certain patient characteristics.Methods.OST measurements were performed in the metacarpophalangeal, proximal intraphalangeal, and wrist joints of 168 patients with RA and 114 controls. OST difference between the 2 groups was statistically examined and subsequently controlled for the effect of possible confounding factors. Diagnostic OST performance was tested by receiver-operating characteristics. Moreover, associations of OST with clinical and serological activity markers (patient group), joint ultrasoun…
Scoring systems for Oral Lichen Planus used by differently experienced raters
2017
BACKGROUND: Scoring systems have been widely used to evaluate the severity and activity of oral lichen planus (OLP). The aim of the present study was to compare two existing (one modified) scoring systems in the evaluation of OLP severity and correlation with pain. Three differently experienced raters were involved. MATERIALS AND METHODS: Consecutive patients with OLP were assessed for pain using the Visual Analogue Scale and examined at 10 intraoral sites before starting (T0) and three weeks after (T1) steroid therapy (Clobetasol). Three differently experienced raters evaluated photographs using two scoring systems designated White-Erosive-Atrophic (WEA) modified from an older WEA system (…
Scores for functional disability in patients with rheumatoid arthritis are correlated at higher levels with pain scores than with radiographic scores
2000
Objective To analyze correlations of functional disability scores with other measures of clinical status, in particular, Larsen radiographic scores and pain scores, in patients with rheumatoid arthritis (RA). Methods The functional capacity of 141 patients with RA (102 women, 39 men; median age 57 years; median disease duration 11.8 years; 83% rheumatoid factor positive) was assessed according to the Stanford Health Assessment Questionnaire (HAQ). Other variables studied included Larsen scores for radiographic damage of the small joints of the hands, wrists, and feet, pain scores by visual analog scale (VAS), Disease Activity Scores, general health scores by VAS, and Beck Depression Invento…
Validity of items assessing self-reported number of breaks in sitting time among children and adolescents
2020
Background: Sedentary behaviour guidelines recommend that individuals should regularly break up sitting time. Accurately monitoring such breaks is needed to inform guidelines concerning how regularly to break up sitting time and to evaluate intervention effects. We investigated the concurrent validity of three &ldquo
Large deflection of magneto-electro-elastic laminated plates
2014
Abstract A model for the large deflection analysis of magneto-electro-elastic laminated plates is derived. The first order shear deformation theory and the von Karman stress function approach are employed. A set of resolving partial differential equations involving kinematical variables and the stress function is obtained as a consequence of the preliminary condensation of the electro-magnetic state to the plate kinematics. A closed form solution for simply-supported plates is presented. Numerical results are carried out for plates consisting of piezoelectric BaTiO 3 and piezomagnetic CoFe 2 O 4 layers. These results show the influence of large deflections on the plate response and could be…
Severity-Related Changes of Bronchial Microbiome in Chronic Obstructive Pulmonary Disease
2014
ABSTRACT Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based techniques identify only a portion of the bacteria in mucosal surfaces. The aim of the study was to determine changes in the bronchial microbiome of COPD associated with the severity of the disease. The bronchial microbiome of COPD patients was analyzed by 16S rRNA gene amplification and pyrosequencing in sputum samples obtained during stable disease. Seventeen COPD patients were studied (forced expiratory volume in the first second expressed as a percentage of the forced vital capacity [FEV 1 %] median, 35.0%; interquartile…
Effects of different simplified milk recording methods on genetic evaluation with Test-Day animal model
2007
The aims of the present study were to compare estimated breeding values (EBV) for milk yield using different testing schemes with a test-day animal model and to evaluate the effect of different testing schemes on the ranking of top sheep. Alternative recording schemes that use less information than that currently obtained with a monthly test-day schedule were employed to estimate breeding values. A random regression animal mixed model that used a spline function of days in milk was fitted. EBVs obtained with alternative recording schemes showed different degrees of Spearman correlation with EBVs obtained using the monthly recording scheme. These correlations ranged from 0.77 to 0.92. A redu…
Ochratoxin A levels in the plasma of healthy blood donors from Valencia and estimation of exposure degree: comparison with previous national Spanish …
2010
Blood plasma levels of ochratoxin A, a toxic secondary metabolite of several fungal species belonging to the genera Aspergillus and Penicillium, were determined in 168 blood donors from the population of Valencia (Spain) using LC-FLD. In conjunction with blood collection, detailed information on diet was obtained by using a questionnaire that encompassed a wide range of products potentially contaminated with the toxin. The investigation revealed a detection frequency of 100%. Mean level was 1.09 microg OTA/l of plasma and concentrations ranged between 0.15 and 5.71 microg OTA/l of plasma. Men's levels were slightly higher than levels observed in women. Results were analysed by Spearman rank…
Die Sprache des Dinges. Heidegger und die Object-Oriented Ontology
2022
Der Aufsatz analysiert die Präsenz von Heideggers Denken in Bezug auf das Thema des "Dings" in den Hauptversionen der objektorientierten Ontologie und versucht die Berührungspunkte und Unterschiede nachzuzeichen. Er konzentriert sich insbesondere auf die von Graham Harman ab 2002 durchgeführte Analyse von Werkzeug-Seins (Tool-Being), um festzustellen, dass Harmans Ansatz, obwohl er heuristisch interessant ist, nur einen sehr begrenzten Text- und Themenbereich innerhalb der Produktion von Heidegger berücksichtigt. Und damit führt sie dazu, die seit den frühen 1930er-Jahren erfolgten Setzungsveränderungen zu unterschätzen, insbesondere im Hinblick auf die Rolle der poetisch-künstlerischen Spr…