Search results for "Array"
showing 10 items of 1264 documents
Liver-specific Ldb1 deletion results in enhanced liver cancer development.
2009
Background & Aims LIM-domain-binding (Ldb) proteins have been demonstrated to be essential not only to key embryonic developmental processes but also to carcinogenesis. We have previously demonstrated Ldb1 to be of high biological and developmental relevance, as a targeted deletion of the Ldb1 gene in mice results in an embryonic lethal and pleiotropic phenotype. Methods We have now established a liver-specific Ldb1 knock out to investigate the role of Ldb1 in carcinogenesis, in particular in hepatocellular carcinoma (HCC) development, in vivo . Results These mice demonstrated a significantly enhanced growth of liver cancer by means of tumor size and number, advocating for an essential role…
A Simultaneous Observation of Lightning by ASIM, Colombia-Lightning Mapping Array, GLM, and ISS-LIS
2021
The Atmosphere-Space Interactions Monitor (ASIM) on the International Space Station (ISS) provides optical radiances and images of lightning flashes in several spectral bands. This work presents a lightning flash simultaneously observed from space by ASIM, the Geostationary Lightning Mapper (GLM) and the Lightning Imaging Sensor on the International Space Station (ISS-LIS); and from ground by the Colombia-Lightning Mapping Array (Colombia-LMA). Volumetric weather radar provides reflectivity data to help to interpret the effects of the cloud particles on the observed optical features. We found that surges in radiance in the band at 777.4 nm appear to be related mostly with lightning processe…
Performance and Implementation Modeling of Gated Linear Networks on FPGA for Lossless Image Compression
2020
Over recent years, imaging systems have seen explosive increase in resolution. These trends present a challenge for resource-constrained embedded imaging devices. Efficient image compression is essential to reduce bandwidth consumption and to increase the capability of on-board storage. Especially, for imaging systems where information loss is not allowed, for example, in medical, military and remote sensing imaging systems. This paper explores the use of Gated Linear Networks (GLNs) for development of embedded lossless compression systems. GLNs have proved themselves via PAQ archiver series, that have been ranked among the top across several lossless compression benchmarks. We propose an a…
Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis
2013
The mechanisms by which deregulated nuclear factor erythroid-2–related factor 2 (NRF2) and kelch-like ECH-associated protein 1 (KEAP1) signaling promote cellular proliferation and tumorigenesis are poorly understood. Using an integrated genomics and 13C-based targeted tracer fate association (TTFA) study, we found that NRF2 regulates miR-1 and miR-206 to direct carbon flux toward the pentose phosphate pathway (PPP) and the tricarboxylic acid (TCA) cycle, reprogramming glucose metabolism. Sustained activation of NRF2 signaling in cancer cells attenuated miR-1 and miR-206 expression, leading to enhanced expression of PPP genes. Conversely, overexpression of miR-1 and miR-206 decreased the exp…
Pushing the Limit – MRI of the Lung Using Hyperpolarized 3-Helium in Conjunction with Parallel Imaging
2009
Imaging of the lung with hyperpolarized 3He became a well known technique in the last decade. Being able to image ventilation and the microstructure of the lung an increase of SNR and a shortage of scan time is eligible. By using a 32-channel phased array the sensitivity was increased dramatically. High resolution 2D-images with a resolution of 1 × 1 mm2 having a 3 mm slice was realized, showing highly detailed images of the lung. By applying parallel imaging techniques the SNR could be increased and scan time was reduced drastically by using a 2D acceleration of R = 4 × 2 with a 3D-protocol covering the whole lung.
FPGA Implementation Of Diffusive Realization For A Distributed Control Operator
2010
International audience; We focus on the question of real-time computation for optimal distributed filtering or control applicable to MEMS Arrays. We present an algorithm for the realization of a linear operator solution to a functional equation through its application to a Lyapunov operatorial equation associated to the heat equation in one dimension. It is based on the diffusive realization, and turns to be well suited for fined grained parallel computer architecture as Field Programmable Gate Arrays (FPGA). An effective FPGA implementation has been successfully carried out. Here, we report the main implementation steps and the final measured performances.
Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068.
2013
Abstract Purpose: The oncogenic PI3K/Akt/mTOR pathway is an attractive therapeutic target in cancer. However, it is unknown whether the pathway blockade required for tumor growth inhibition is clinically achievable. Therefore, we conducted pharmacodynamic studies with GDC-0068, an ATP competitive, selective Akt1/2/3 inhibitor, in preclinical models and in patients treated with this compound. Experimental Design: We used a reverse phase protein array (RPPA) platform to identify a biomarker set indicative of Akt inhibition in cell lines and human-tumor xenografts, and correlated the degree of pathway inhibition with antitumor activity. Akt pathway activity was measured using this biomarker se…
Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
2011
Here we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein toxins and being important for the pathogenesis in humans of many Gram positive and Gram negative bacteria. Their mode of action is deceptively simple, poking holes in the plasma membrane of cells. The scattered studies to date of PFT-host cell interactions indicate a handful of genes are involved in cellular defenses to PFTs. How many genes are involved in cellular defenses against PFTs and how cellular defenses are coordinated are unknown. To address these questions, we pe…
Effects of Scrophularia ningpoensis Hemsl. on Inhibition of Proliferation, Apoptosis Induction and NF-κB Signaling of Immortalized and Cancer Cell Li…
2012
Scrophularia ningpoensis has been used in China for centuries as a herbal tea to treat various diseases. Based on the numerous animal studies on its pharmaceutical effects and the long time clinical experiences, we studied the molecular and cellular mechanism underlying the bioactivity of aqueous extract of Scrophularia and its isolated compounds. Seven isolated compounds, unlike Scrophularia extract, failed to induce cytotoxicity on HaCaT cells, but their combination improved the effect of extract. Tumor cell line selectivity was not observed, when we studied its cytotoxic effect on melanoma cell lines. The apoptotic and anti-inflammatory effects of Scrophularia extract have been demonstra…
DNA nanofilm thickness measurement on microarray in air and in liquid using an atomic force microscope.
2005
International audience; The measurement of the thickness of DNA films on microarray as a function of the medium (liquid, air) is gaining importance for understanding the signal response of biosensors. Thiol group has been used to attach DNA strands to gold micropads deposited on silicon surface. Atomic force microscopy (AFM) was employed in its height mode to measure the change in the pad thickness and in its force mode to measure the indentation depth of the nanofilm. A good coherence between the height and force modes is observed for the film thickness in air. The adhesion force was found to be an alternative way to measure the surface coverage of the biolayer at nanoscopic scale. However…