Search results for "Array"
showing 10 items of 1264 documents
Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila
2008
Transcriptional analysis of chromatin regulator mutants in Drosophila melanogaster identified clusters of functionally related genes conserved in other insect species.
Pharmacogenomics of cantharidin in tumor cells.
2014
Cantharis vesicatoria (blister beetle) is used in Chinese medicine and has been categorized as highly toxic in the Chinese pharmacopeia. In Europe, Cantharis patches have been used since ages to treat various skin-related diseases. We investigated the cytotoxicity of the Cantharis ingredient, cantharidin, in 41 tumor cell lines (Oncotest panel) and compared the results with those of 60 cell lines of the National Cancer Institute, USA. We found profound activity at low micromolar concentrations (log ₁₀IC₅₀ values between -6.980 and 5.009 M). Cantharidin bound to protein phosphatase 2A (PP2A) with higher affinity (-8.12 kcal/mol) than to PP1 (-6.25 kcal/mol) in molecular docking analyses. Usi…
Engineering a 2D protein-DNA crystal.
2005
(Figure Presented) Weaving with DNA: A DNA-binding protein was used to control the structure of a self-assembled 2D crystal. In the absence of protein, four oligonucleotides hybridize to form a Kagome lattice of interwoven double helices with p3 symmetry (see image). Addition of protein RuvA during assembly changes the symmetry and connectivity to give a DNA-protein crystal with an approximately square unit cell. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
Tissue microarrays: applications in study of p16 and p53 alterations in Ewing's cell lines
2008
Background Tissue microarrays (TMAs) are used to study genomics and proteomics in several tumour tissue samples. Cell lines (CC) are of great importance in the study of the genetic changes in tumours, and some reveal several aspects of tumour oncogenesis. There are few published reports on Ewing's tumours with TMAs including original tumours (OT) and corresponding CC. Methods We have performed four TMAs, from 3 OT and the corresponding CC of successive in vivo and in vitro tumour passages. Xenotransplant CC in nude mice from OT (XT/OT) was made. Subsequently multiple XT were performed and in vitro XT cell line (CC/XT) was obtained. In vivo re-inoculation of CC/XT (XT/CC) was planned. TMAs w…
Efficient smart-camera accelerator: A configurable motion estimator dedicated to video codec
2013
Smart cameras are used in a large range of applications. Usually the smart cameras transmit the video or/and extracted information from the video scene, frequently on compressed format to fit with the application requirements. An efficient hardware accelerator that can be adapted and provide the required coding performances according to the events detected in the video, the available network bandwidth or user requirements, is therefore a key element for smart camera solutions. We propose in this paper to focus on a key part of the compression system: motion estimation. We have developed a flexible hardware implementation of the motion estimator based on FPGA component, fully compatible with…
Hardware Implementation of a Configurable Motion Estimator for Adjusting the Video Coding Performances
2012
International audience; Despite the diversity of video compression standard, the motion estimation still remains a key process which is used in most of them. Moreover, the required coding performances (bit-rate, PSNR, image spatial resolution, etc.) depend obviously of the application, the environment and the network communication. The motion estimation can therefore be adapted to fit with these performances. Meanwhile, the real time encoding is required in many applications. In order to reach this goal, we propose in this paper a hardware implementation of the motion estimator which enables the integer motion search algorithms to be modified and the fractional search and variable block siz…
Studying Nucleosomes Positioning by a Multi-Layer Model
2007
Eukaryotic DNA is packaged into a highly compact and dynamic structure called chromatin. While this packaging allows the cell to organize a large and complex genome in the nucleus, it can also block the access of transcription factors and other proteins to DNA. Nucleosomes are the fundamental repeating units of eukaryotic chromatin. Nucleosome position can be regulated in vivo by multi-subunit chromatin remodeling complexes, and their position can influence gene expression in eukaryotic cells. Alterations in chromatin structure, and hence in nucleosome organization, can result in a variety of diseases, including cancer, highlighting the need to achieve a better understanding of the molecula…
Multiple modular very long instruction word processors based on field programmable gate arrays
2007
Modern field programmable gate array (FPGA) chips, with their large memory capacity and reconfigurability potential, are opening new frontiers in rapid prototyping of embedded systems. With the advent of high-density FPGAs, it is now possible to implement a high-performance very long instruction word (VLIW) processor core in an FPGA. This paper describes research results about enabling the DSP TMS320 C6201 model for real-time image processing applications by exploiting FPGA technology. We present a modular DSP C6201 VHDL model with a variable instruction set. We call this new development a minimum mandatory modules (M3) approach. Our goals are to keep the flexibility of DSP in order to shor…
Suffix Array Construction on Multi-GPU Systems
2019
Suffix arrays are prevalent data structures being fundamental to a wide range of applications including bioinformatics, data compression, and information retrieval. Therefore, various algorithms for (parallel) suffix array construction both on CPUs and GPUs have been proposed over the years. Although providing significant speedup over their CPU-based counterparts, existing GPU implementations share a common disadvantage: input text sizes are limited by the scarce memory of a single GPU. In this paper, we overcome aforementioned memory limitations by exploiting multi-GPU nodes featuring fast NVLink interconnects. In order to achieve high performance for this communication-intensive task, we …
Investigating the effect of residual stress on hydrogen cracking in multi-pass robotic welding through process compatible non-destructive testing
2021
Abstract In this paper, the effect of Welding Residual Stress (WRS) on the size and morphology of hydrogen-induced cracks (HIC) is studied. Four samples were manufactured using a 6-axis welding robot and in two separate batches. The difference between the two batches was the clamping system used, which resulted in different amounts of welding deformation and WRS. The hydrogen cracks were intentionally manufactured in the samples using a localised water-quenching method, where water was sprayed over a specific weld pass in a predetermined position. The Phased-Array Ultrasonic Testing (PAUT) system was implemented during the welding process (high-temperature in-process method), to detect the …