Search results for "Arrow"

Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs

2015

International audience; Fanconi anemia is a DNA repair-deficiency syndrome mainly characterized by cancer predisposition and bone marrow failure. Trying to restore the hematopoietic function in these patients, lentiviral vector-mediated gene therapy trials have recently been proposed. However, because no insertional oncogenesis studies have been conducted so far in DNA repair-deficiency syndromes such as Fanconi anemia, we have carried out a genome-wide screening of lentiviral insertion sites after the gene correction of Fanca-/- hematopoietic stem cells (HSCs), using LAM-PCR and 454-pyrosequencing. Our studies first demonstrated that transduction of Fanca-/- HSCs with a lentiviral vector d…

How I diagnose and treat splenic lymphomas.

2011

Abstract The incidental finding of an isolated splenomegaly during clinical assessment of patients evaluated for unrelated causes has become increasingly frequent because of the widespread use of imaging. Therefore, the challenging approach to the differential diagnosis of spleen disorders has emerged as a rather common issue of clinical practice. A true diagnostic dilemma hides in distinguishing pathologic conditions primarily involving the spleen from those in which splenomegaly presents as an epiphenomenon of hepatic or systemic diseases. Among the causes of isolated splenomegaly, lymphoid malignancies account for a relevant, yet probably underestimated, number of cases. Splenic lymphoma…

Nonlinear Diffusion in Transparent Media

2021

Abstract We consider a prototypical nonlinear parabolic equation whose flux has three distinguished features: it is nonlinear with respect to both the unknown and its gradient, it is homogeneous, and it depends only on the direction of the gradient. For such equation, we obtain existence and uniqueness of entropy solutions to the Dirichlet problem, the homogeneous Neumann problem, and the Cauchy problem. Qualitative properties of solutions, such as finite speed of propagation and the occurrence of waiting-time phenomena, with sharp bounds, are shown. We also discuss the formation of jump discontinuities both at the boundary of the solutions’ support and in the bulk.

A Pedagogical Proof of Arrow's Impossibility Theorem

1999

In this note I consider a simple proof of Arrow's Impossibility Theorem (Arrow 1963). I start with the case of three individuals who have preferences on three alternatives. In this special case there are 133=2197 possible combinations of the three individuals' rational preferences. However, by considering the subset of linear preferences, and employing the full strength of the IIA axiom, I reduce the number of cases necessary to completely describe the SWF to a small number, allowing an elementary proof suitable for most undergraduate students. This special case conveys the nature of Arrow's result. It is well known that the restriction to three options is not really limiting (any larger se…

Dielectric relaxation models applied of the dynamics of myoglobin as determined by Mössbauer spectroscopy

1996

Abstract Protein specific modes of motions are found in myoglobin crystals above 180 K. In this contribution we show that this type of motions can be analyzed by a Davidson-Cole, a Cole-Cole or a Havriliak-Negami distribution in analogy to dielectric relaxation. However, the temperature dependence of the obtained parameters is quite unusual indicating a broadening of the distributions with temperature instead of motional narrowing. This can be understood from the picture of conformational substates if one assumes that more and more substates become accessible with increasing temperature. The result shows that the analogy between glass forming organic liquids and proteins should not be exagg…

Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis

2006

Familial haemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder characterised by constitutive defects in cellular cytotoxicity resulting in fever, hepatosplenomegaly and cytopenia, and the outcome is fatal unless treated by chemoimmunotherapy followed by haematopoietic stem‐cell transplantation. Since 1999, mutations in the perforin gene giving rise to this disease have been identified; however, these account only for 40% of cases. Lack of a genetic marker hampers the diagnosis, suitability for transplantation, selection of familial donors, identification of carriers, genetic counselling and prenatal diagnosis. Mutations in the Munc13–4 gene have recently been des…

Arrow-Hahn economic models with weakened conditions of continuity

2006

EPCR Guides Hematopoietic Stem Cells Homing to the Bone Marrow Independently of Niche Clearance

2016

Abstract Bone marrow (BM) homing and lodgment of long-term repopulating hematopoietic stem cells (LT-HSCs) are active and essential first steps during embryonic development and in clinical stem cell transplantation. Rare, BM LT-HSCs endowed with the highest self-renewal and durable repopulation potential, functionally express the anticoagulant endothelial protein C receptor (EPCR) and PAR1. In addition to coagulation and inflammation, EPCR-PAR1 signaling independently controls a BM LT-HSC retention-release switch via regulation of nitric oxide (NO) production within LT-HSCs. EPCR+ LT-HSCs are maintained in thrombomodulin+ (TM) periarterial BM microenvironments via production of activated pr…

From Regenerative Medicine to Endothelial Progenitor Cells as Potential Candidates

2017

A promising branch of translational medicine is Regenerative Medicine (RegMed). RegMed aims to improve health and quality of life by restoring, maintaining or enhancing tissues and functions of organs. In order to achieve this, RegMed utilizes several approaches. Among these, cell-based therapy represents the central focus of RegMed. Several cellular types have been considered for the investigation and application of regenerative cell therapy in disease organs. and bone marrow (BM)-derived endothelial progenitor cells (BM EPCs) are emerging as potential candidates. Here, particular emphasis is given to the description of their biological features, for understanding their relevance and poten…

Experimental investigation on PLC signal crossing of power transformers

2014

In this work the use of PLC in MV-LV networks is investigated, by means of experimental tests in the case of a two-ways MV/LV communication between two secondary substations. The two substations are connected by a MV overhead power line. Moreover each substation has a by-pass connection at MV bus-bars and a MV/LV power transformer. A ST7580 transceiver is used to inject the communication signal. The transceiver is embedded in a new interface device developed by the authors. In the paper the communication issues are introduced and some experimental tests are presented and discussed. Such tests have been carried out in the presence of voltage net, i.e. 24 kV, with the aim to verify the possib…