Search results for "Ash"
showing 10 items of 1718 documents
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
AGILE 3+ Score for the Diagnosis of Advanced Fibrosis and for Predicting Liver-related Events in NAFLD.
2022
Background & aims: We aimed to assess the diagnostic accuracy of AGILE 3+, a recently developed score based on the combination of aspartate aminotransferase/alanine aminotransferase ratio, platelet count, diabetes status, sex, age, and liver stiffness measurement (LSM) by transient elastography, when compared with Fibrosis-4 (FIB-4) and LSM, for the diagnosis of advanced fibrosis and for the prediction of liver-related events (LREs) occurrence in patients with NAFLD. Methods: A total of 614 consecutive patients with biopsy-proven NAFLD or clinical diagnosis of NAFLD-related compensated cirrhosis were enrolled. LREs were recorded during follow-up. FIB-4, LSM by transient elastography (Fi…
Exact mechanical models of fractional hereditary materials
2012
Fractional Viscoelasticity is referred to materials, whose constitutive law involves fractional derivatives of order β R such that 0 β 1. In this paper, two mechanical models with stress-strain relation exactly restituting fractional operators, respectively, in ranges 0 β 1 / 2 and 1 / 2 β 1 are presented. It is shown that, in the former case, the mechanical model is described by an ideal indefinite massless viscous fluid resting on a bed of independent springs (Winkler model), while, in the latter case it is a shear-type indefinite cantilever resting on a bed of independent viscous dashpots. The law of variation of all mechanical characteristics is of power-law type, strictly related to th…
Physiotherapists' lived experiences of decision making in therapeutic encounters with persons suffering from whiplash-associated disorder: A hermeneu…
2020
Conceptual discussions related to clinical reasoning and decision making have evolved over the years from biomedical to incorporating more holistic approach to reasoning. Empirical studies exploring clinical reasoning and decision making in physiotherapy practice have mostly focused on aspects of managing persons with low back pain, such as exercise prescription, education and communicating diagnosis. There is a paucity of studies exploring decision making in whiplash‐associated disorder (WAD); thus, the aim of this study was to explore the physiotherapists' lived experiences of decision making related to treating persons with WAD. A qualitative research design based on hermeneutic phenomen…
Taxonomic review of the fungal-inhabiting plant bug genera Bothriomiris and Dashymenia (Hemiptera: Heteroptera: Miridae: Cylapinae: Bothriomirini), w…
2016
The two closely related and frequently confused genera of the fungal-inhabiting plant bug subfamily Cylapinae, Bothriomiris Kirkaldy, 1902 and Dashymenia Poppius, 1910 are redefined and reviewed. Two new species of Dashymenia, D. artchawakomi, new species and D. gorczycai, new species, are described from Thailand. Bothriomiris capillosus Yasunaga, 2000 and B. yakushima Yasunaga & Miyamoto, 2012 are transferred to the genus Dashymenia Poppius, and a revised key to the two genera is provided. Color habitus images of the adults are given for Dashymenia artchawakomi, D. capillosa, and D. gorczycai. The male genitalic structures of the following species are illustrated: Bothriomiris ernsti Yasun…
A new population of terrestrial gamma‐ray flashes in the RHESSI data
2015
Terrestrial gamma-ray flashes (TGFs) are the most energetic photon phenomenon occurring naturally on Earth. An outstanding question is as follows: Are these flashes just a rare exotic phenomenon or are they an intrinsic part of lightning discharges and therefore occurring more frequently than previously thought? All measurements of TGFs so far have been limited by the dynamic range and sensitivity of spaceborne instruments. In this paper we show that there is a new population of weak TGFs that has not been identified by search algorithms. We use the World Wide Lightning Location Network (WWLLN) to identify lightning that occurred in 2006 and 2012 within the 800 km field of view of Reuven Ra…
A next generation Ultra-Fast Flash Observatory (UFFO-100) for IR/optical observations of the rise phase of gamma-ray bursts
2012
The Swift Gamma-ray Burst (GRB) observatory responds to GRB triggers with optical observations in ~ 100 s, but cannot respond faster than ~ 60 s. While some ground-based telescopes respond quickly, the number of sub-60 s detections remains small. In mid- to late-2013, the Ultra-Fast Flash Observatory-Pathfinder is to be launched on the Lomonosov spacecraft to investigate early optical GRB emission. This pathfinder mission is necessarily limited in sensitivity and event rate; here we discuss a next generation rapid-response space observatory. We list science topics motivating our instruments, those that require rapid optical-IR GRB response, including: A survey of GRB rise shapes/times, meas…
Enhanced detection of terrestrial gamma-ray flashes by AGILE
2015
Abstract At the end of March 2015 the onboard software configuration of the Astrorivelatore Gamma a Immagini Leggero (AGILE) satellite was modified in order to disable the veto signal of the anticoincidence shield for the minicalorimeter instrument. The motivation for such a change was the understanding that the dead time induced by the anticoincidence prevented the detection of a large fraction of Terrestrial Gamma‐Ray Flashes (TGFs). The configuration change was highly successful resulting in an increase of one order of magnitude in TGF detection rate. As expected, the largest fraction of the new events has short duration (<100 μs), and part of them has simultaneous association with light…
Hierarchies of geometric entanglement
2007
We introduce a class of generalized geometric measures of entanglement. For pure quantum states of $N$ elementary subsystems, they are defined as the distances from the sets of $K$-separable states ($K=2,...,N$). The entire set of generalized geometric measures provides a quantification and hierarchical ordering of the different bipartite and multipartite components of the global geometric entanglement, and allows to discriminate among the different contributions. The extended measures are applied to the study of entanglement in different classes of $N$-qubit pure states. These classes include $W$ and $GHZ$ states, and their symmetric superpositions; symmetric multi-magnon states; cluster s…
Strong monogamy of bipartite and genuine multipartite entanglement: The Gaussian case
2007
We demonstrate the existence of general constraints on distributed quantum correlations, which impose a trade-off on bipartite and multipartite entanglement at once. For all N-mode Gaussian states under permutation invariance, we establish exactly a monogamy inequality, stronger than the traditional one, that by recursion defines a proper measure of genuine N-partite entanglement. Strong monogamy holds as well for subsystems of arbitrary size, and the emerging multipartite entanglement measure is found to be scale invariant. We unveil its operational connection with the optimal fidelity of continuous variable teleportation networks.