Search results for "Assembling"

Mucoadhesive PEGylated inulin-based self-assembling nanoparticles: In vitro and ex vivo transcorneal permeation enhancement of corticosteroids

2019

Abstract As transcorneal drug delivery is still a challenge, the scope of the present study was to prepare useful nanosystems able to enhance transcorneal permeation/penetration of drugs. Moreover, this work aims to evaluate the effectiveness of inulin-based nanosystems in the specific field of ocular drug delivery and the effect of PEG chains to promote mucoadhesion, stability and transcorneal penetration/permeation enhancer effect of self-assembling nanoparticles in vitro (transwell systems and HCE) and ex vivo (Franz cells and bovine cornea). In particular, inulin was chosen as the starting natural polysaccharide polymer to design a novel amphiphilic derivative named INU-EDA-RA-PEG capab…

Self assembling in the production of Biomimetic matrices for regenerative medicine

2011

SELF ASSEMBLED AND CROSSLINKED FIBRILLAR SCAFFOLDS FOR CARTILAGE REGENERATION.

2010

Structure, stability, and fragmentation of sodium bis(2-ethylhexyl)sulfosuccinate negatively charged aggregates in vacuo by MD simulations.

2014

Negatively charged supramolecular aggregates formed in vacuo by n bis(2-ethylhexyl)sulfosuccinate (AOT(-)) anions and n + n(c) sodium counterions (i.e., [AOT(n) Na(n+nc)](nc)) have been investigated by molecular dynamics (MD) simulations for n = 1 to 20 and n(c) = -1 to -5. By comparing the maximum excess charge values of negatively and positively charged AOTNa aggregates, it is found that the charge storage capability is higher for the latter systems, the difference decreasing as the aggregation number increases. Statistical analysis of physical properties like gyration radii and moment of inertia tensors of aggregates provides detailed information on their structural properties. Even for …

Supramolecular polymer chemistry meets computational chemistry: theoretical simulations on advanced self-assembling chiral materials

2018

AbstractComputational chemistry has gained an important role as a key tool to help rationalize the self-assembly of organic building blocks decorated with supramolecular recognition motifs. The adv...

Surfactant self-assembling in gas phase: positively monocharged sodium alkanesulfonate clusters

2009

The Role of Self-Assembling Lipid Molecules in Vaccination

2018

Abstract The advent of vaccines represents one of the most significant advances in medical history. The protection provided by vaccines has greatly contributed in reducing the number of cases of infections and most notably to the eradication of small pox. A large number of new technologies and approaches in vaccine development are currently being investigated with the goal of providing the basis for the next generation of prophylactics against an ever-expanding list of emerging and reemerging pathogens. In this chapter, we will focus on the role of lipids and lipid self-assembling vesicles in new and promising vaccination approaches. We will start by describing how lipids can induce activat…

Characterization of the metal artefacts of the two craft-quarters of the roman vicus Bliesbruck (Moselle)

2014

Diese Arbeit ist ein vollständiges Studium der Metallfunde aus den zwei Handwerkervierteln von Bliesbruck (Moselle, Frankreich). Diese Funde stammen aus vierzigjahrelangen Ausgrabungen. Das Korpus besteht aus 450 Kg Metall (Eisen, Kupferlegierungen, weisse Metalle, Gold) wovon 4 200 Objekte und 22 000 Nägel. Eine Objekt- und Funktionsidentifizierung und eine typologische Nägelzahl haben es ermöglicht, die Objektverbindungen wieder zusammenzusetzen und die Daten nach verschiedenen Kriterien einander gegenüberzustellen : Metall, Lage (Viertel und Grundstück), Chronologie und Befundnummertyp. Diese Datenüberfülle und -verschiedenheit ermöglichen das Korpus nach vielartigen geographischen Maβst…

Effects of the net charge on abundance and stability of supramolecular surfactant aggregates in gas phase

2011

Self-assembling of amphiphilic molecules under electrospray ionization (ESI) conditions is characterized by quite unexpected phenomenology. The noticeable differences with respect to the condensed phase are attributable to the absence of the surfactant-solvent interactions, the presence of net charge in the aggregates, and the strong deviation from equilibrium conditions. Aiming to investigate the effects of the net charge on abundance and stability of supramolecular surfactant aggregates, positively and negatively charged aggregates of sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and sodium methane sulfonate (MetS), butane sulfonate (ButS) and octane sulfonate (OctS) have been studied by E…

Oscillatory dynamics of the Belousov-Zhabotinsky system in the presence of a self-assembling nonionic polymer. Role of the reactants concentration.

2010

In the present study, the role played by the reactants concentration on the nonlinear response of a Belousov–Zhabotinsky (BZ) system to the addition of a self-assembling non-ionic polymer, poly(ethylene glycol) (PEG), has been assessed. The oscillatory parameters are influenced to an extent that significantly depends on the concentration of both the polymer and the Belousov–Zhabotinsky components. The effects obtained were attributed to the reaction among some of the BZ key species and the backbone and the alcoholic functional groups of the polymer, both in its monomeric and aggregated forms. Support to the proposed perturbation mechanism has been provided by performing numerical simulation…