Search results for "Association."

UPC++ for bioinformatics: A case study using genome-wide association studies

2014

Modern genotyping technologies are able to obtain up to a few million genetic markers (such as SNPs) of an individual within a few minutes of time. Detecting epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important but time-consuming operation since statistical computations have to be performed for each pair of measured markers. Therefore, a variety of HPC architectures have been used to accelerate these studies. In this work we present a parallel approach for multi-core clusters, which is implemented with UPC++ and takes advantage of the features available in the Partitioned Global Address Space and Object Oriented Programming models. Our solution is base…

The relationship between obsessions and the self: Feared and actual self-descriptions in a clinical obsessive-compulsive disorder sample.

2022

Cognitive models of obsessive-compulsive disorder (OCD) posit the relevance of the self in OCD, although the nature of this association is still unclear. We aimed to explore actual and feared selves and its association with obsessions and intrusions in a group of OCD patients. A group of 58 patients with OCD identified their most upsetting obsession and intrusion (non-clinical obsession) experienced in the past three months. These cognitions were classified as either moral-based or autogenous (obsessions n=32; intrusions n=26) or non-moral-based or reactive, depending on their content. Next, patients described their actual self and their feared self, that is, the person they feared being or…

Association Between Long-Term Job Strain and Metabolic Syndrome Factor Across Sex and Occupation

2006

The present study investigated whether long-term job strain increases the prevalence of risk for metabolic syndrome, a cluster of risk factors for cardiovascular diseases, across sex and occupation. The participants (64 men, 62 women) were drawn from the Jyväskylä Longitudinal Study of Personality and Social Development, Finland. Job strain was measured by a combination of high job demands and low job control ( Karasek, 1979 ) at ages 36 and 42. Metabolic syndrome was measured at age 42. The results indicated that both sex and occupational group moderated the association between long-term job strain and the metabolic syndrome factor but in an unexpected way. In women, low long-term job str…

Morpho-sedimentary setting and evolution of Marettimo Valley (Egadi Islands, Sicily) during middle-late Quaternary: interaction between sea level cha…

2017

We present morphological and stratigraphic results coming from surveys acquired in a NNW-SSE trending submarine depression (Marettimo Valley) located in the Egadi Islands (western Sicily offshore). In this area the seafloor is characterized by both depositional and erosional features generated under a variety of sedimentary processes. We identified two seismic facies units that are correlatable to: A) the progradation of shallow water (coastal to offshore) deposits during forced-regression sedimentary process, and B) contourite drifts emplaced by geostrophic currents through the Marettimo Valley. This unusual association of very shallow water contourites and shelf margin deposits originates…

Association of olfatory dysfunction with plasma lipids and blood pressure in a high cardiovascular risk population: sex-specific analysis

2021

Abstract Background Impaired sense of smell is a predictor of morbidity and mortality, including cardiovascular diseases. Likewise, several studies have reported sex-specific associations between olfactory function and cardiometabolic measures including plasma lipids and blood pressure. Thus, in a representative sample of US adults from the National Health and Nutrition Examination Survey (NHANES) study, olfactory dysfunction was associated with significantly higher total cholesterol (TC) and LDL-C among older men, but significantly lower TC among older women. However, considering that more studies in diverse population are needed, our aim was to analyze the association between the olfactor…

Mujeres, trabajo y asociación rural

2019

Nemo regulates cell dynamics and represses the expression of miple, a midkine/pleiotrophin cytokine, during ommatidial rotation

2013

AbstractOmmatidial rotation is one of the most important events for correct patterning of the Drosophila eye. Although several signaling pathways are involved in this process, few genes have been shown to specifically affect it. One of them is nemo (nmo), which encodes a MAP-like protein kinase that regulates the rate of rotation throughout the entire process, and serves as a link between core planar cell polarity (PCP) factors and the E-cadherin–β-catenin complex. To determine more precisely the role of nmo in ommatidial rotation, live-imaging analyses in nmo mutant and wild-type early pupal eye discs were performed. We demonstrate that ommatidial rotation is not a continuous process, and …

Insight into genetic susceptibility to male breast cancer by multigene panel testing: results from a multicenter study in Italy

2019

Breast cancer (BC) in men is rare and genetic predisposition is likely to play a relevant role in its etiology. Inherited mutations in BRCA1/2 account for about 13% of all cases and additional genes that may contribute to the missing heritability need to be investigated. In our study, a well-characterized series of 523 male BC (MBC) patients from the Italian multicenter study on MBC, enriched for non-BRCA1/2 MBC cases, was screened by a multigene custom panel of 50 cancer-associated genes. The main clinical-pathologic characteristics of MBC in pathogenic variant carriers and non-carriers were also compared. BRCA1/2 pathogenic variants were detected in twenty patients, thus, a total of 503 n…

Type A competitiveness traits correlate with downregulation of c-Fos expression in patients with type 1 diabetes.

2019

International audience; AimType A personality has been associated with increased survival in people with type 1 diabetes (T1D). Systemic low-grade inflammation may play a critical role, as suggested in recent reports, although the links between the inflammatory circulating transcriptome and Type A remain unknown. This prompted our exploration of the potential associations between Type A personality and c-Fos gene expression, a candidate gene closely linked to inflammatory processes, in T1D.MethodsType A personality was assessed by Bortner questionnaire in patients with T1D, and two subscales – ‘speed’ and ‘competitiveness’ – were used to measure these specific dimensions of Type A. Expressi…

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol depe…

2012

Background Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. Methods We investigated a total number of 1,845 alcohol-dependent subjects recruited from inpatient facilities in Germany and 1,863 controls for the mu-opioid receptor (OPRM1) polymorphism using chi-square statistics. Results An association between the OPRM variant and AD was detected (p = 0.022), in recessive (AA vs. GA/GG) and co-dominant (AA vs. GA) models of inheri…