Search results for "Asthma"

showing 10 items of 860 documents

Chemical fingerprint of outdoor PM2.5 in Malta

2015

Intro: RESPIRA (EU Funded - Italia-Malta 07-13) indicated that living in Malta is a risk factor for asthma. Aim: To determine the chemical profile of PM2.5 in Malta, and compare with reference values. Methods: Using FAI pumps at 10l/min/48hr, samples were collected on Teflon and Quartz filters from 6 schools and 46 homes in Malta. Total ICP-MS measurement (Residual+extracted), X ray Fluorescence, and thermo-optical methods(TO) were used for analysis by CNR in Rome. Aeroqual IQM60 counters were used for total PM2.5 mass. All data in ng/m3, Mean, (1st to 3rd quartile) of all 48 hour measurements.

Total organic carbonAsthma -- Maltabusiness.industryAnalytical chemistryAtmospheric deposition -- MaltaX-ray fluorescencechemistry.chemical_elementMineralogyVanadiumCrude oilchemistry.chemical_compoundNitratechemistryReference valuesMedicinebusinessElemental carbonArsenicAir -- Pollution -- Malta6.2 Occupational and Environmental Health
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Development of New Antiasthmatic Drugs from Traditional Medicine?

1991

Several plants are used in traditional medicine in the treatment of bronchial asthma. We are trying to identify the active compound(s) and their mode of action.

Traditional medicinebusiness.industryfood and beveragesmacromolecular substancesrespiratory systemPharmacologymedicine.diseaserespiratory tract diseasesActive compoundDisodium cromoglycatemedicineAntiasthmatic drugsbusinessBronchial obstructionMode of actionAsthma
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Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells

2015

Abstract Coevolution of ticks and the vertebrate immune system has led to the development of immunosuppressive molecules that prevent immediate response of skin-resident immune cells to quickly fend off the parasite. In this article, we demonstrate that the tick-derived immunosuppressor sialostatin L restrains IL-9 production by mast cells, whereas degranulation and IL-6 expression are both unaffected. In addition, the expression of IL-1β and IRF4 is strongly reduced in the presence of sialostatin L. Correspondingly, IRF4- or IL-1R–deficient mast cells exhibit a strong impairment in IL-9 production, demonstrating the importance of IRF4 and IL-1 in the regulation of the Il9 locus in mast cel…

Transcription GeneticCell DegranulationInterleukin-1betaImmunologyBiologyArticleCell DegranulationHost-Parasite InteractionsMiceImmune systemImmunityAnimalsImmunology and AllergyInterleukin 9Mast CellsPromoter Regions GeneticMice KnockoutRegulation of gene expressionMice Inbred BALB CBinding SitesInterleukin-6Interleukin-9DegranulationReceptors Interleukin-1CystatinsAsthmaImmunity InnateMice Inbred C57BLGene Expression RegulationInterferon Regulatory FactorsImmunologySignal transductionImmunosuppressive AgentsProtein BindingSignal TransductionInterferon regulatory factors
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Regulatory T Cells More Effectively Suppress Th1-Induced Airway Inflammation Compared with Th2

2011

Abstract Asthma is a syndrome with different inflammatory phenotypes. Animal models have shown that, after sensitization and allergen challenge, Th2 and Th1 cells contribute to the development of allergic airway disease. We have previously demonstrated that naturally occurring regulatory T cells (nTregs) can only marginally suppress Th2-induced airway inflammation and airway hyperresponsiveness. In this study, we investigated nTreg-mediated suppression of Th2-induced and Th1-induced acute allergic airway disease. We demonstrate in vivo that nTregs exert their suppressive potency via cAMP transfer on Th2- and Th1-induced airway disease. A comparison of both phenotypes revealed that, despite …

TransgeneImmunologyMice TransgenicInflammationT-Lymphocytes RegulatoryMiceTh2 CellsIn vivoImmunitymedicineAnimalsImmunology and AllergyPotencyCells CulturedSensitizationAsthmaInflammationMice KnockoutMice Inbred BALB Cbusiness.industryTh1 Cellsrespiratory systemmedicine.diseasePhenotypeCoculture TechniquesImmunity Innaterespiratory tract diseasesDisease Models Animalmedicine.anatomical_structureAcute DiseaseImmunologyFemaleDisease SusceptibilityBronchial Hyperreactivitymedicine.symptombusinessThe Journal of Immunology
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Effects of a structured educational intervention in moderate-to-severe elderly asthmatic subjects.

2019

Background: Adherence to inhaled drugs is linked to patients’ satisfaction with their device, and an incorrect use can negatively affect the outcomes of asthma treatment. We speculated that this is particularly true in elderly asthmatic subjects. Aim: We performed a national pre-post interventional multicentre study, enrolling moderate-to-severe asthmatic subjects aged ≥65 ​years treated with fixed inhaled combination drugs by dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI). Adherence and critical errors were evaluated by means of validated questionnaires at first visit (V1) and after 3–6 months (V2). At V1, subjects underwent intensive training on the correct use of the…

Vital capacityACT asthma control testExacerbationSAE severe asthma exacerbationSF12chlorofluorocarbonsmental health composite scoreEDUCA elderly and device use in chronic asthmaPCS physical health composite scoreACT asthma control test; AHDS hospital anxiety depression scale; Asthma; CFC chlorofluorocarbons; Device misuse; EDUCA elderly and device use in chronic asthma; Education; Elderly; FEV1 forced expiratory volume 1s second; FVC forced vital capacity; ICS inhaled corticosteroids; LABA long-acting β2 agonist; LAMA long-acting muscarinic antagonists; MCS mental health composite score; PCS physical health composite score; PROs patient-reported outcomes; SAE severe asthma exacerbation; SF12 short form health survey; mMRC modified medical research councilEDUCAFEV10302 clinical medicineElderlyImmunology and AllergyMedicine030223 otorhinolaryngologybiologymMRC modified medical research councilsevere asthma exacerbationmodified medical research councilLAMASAELamaelderly and device use in chronic asthmaMetered-dose inhalerDry-powder inhalerDevice misusePROs patient-reported outcomesCFCPCSpatient-reported outcomesmMRClcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinelong-acting β2 agonistmedicine.medical_specialtyImmunologyLABAphysical health composite scoreArticleLAMA long-acting muscarinic antagonistsAHDSEducation03 medical and health sciencesFEV1/FVC ratiolong-acting muscarinic antagonistsforced vital capacitySF12 short form health surveyAsthma; Device misuse; Education; ElderlyInternal medicineMCS mental health composite scoreforced expiratory volume 1s secondAsthmabusiness.industryFEV1 forced expiratory volume 1s secondInhalerasthma control testbiology.organism_classificationmedicine.diseaseCFC chlorofluorocarbonsACTICS inhaled corticosteroidsFVCAsthmaMCShospital anxiety depression scale030228 respiratory systemICSAHDS hospital anxiety depression scaleFVC forced vital capacityPROsshort form health surveyinhaled corticosteroidslcsh:RC581-607businessLABA long-acting β2 agonistThe World Allergy Organization journal
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Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-…

2021

Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18–60 years at baseline (female 51%), BMI and the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) as well as forced mid-expiratory flow (FEF25–75%) were measured three times over 20 follow-up years. The causal effects of BMI in childhood and adulthood on FEV1/FVC and FEF25–75% were assessed in predictive (BMI averaged over 1st and 2nd, lung function (LF) averaged over 2nd and 3rd fol…

Vital capacityPulmonary Disease Chronic Obstructive0302 clinical medicinePULMONARY-DISEASEMedicineLungPublic Environmental & Occupational HealthOriginal Research2. Zero hungerRISK0303 health sciencesCOPDInstrumental variableAge Factorslongitudinal cohortgenetic score3. Good healthOBESITYCohortLife course approachFemalePublic HealthPublic aspects of medicineRA1-1270Life Sciences & BiomedicineAdultbody mass index1117 Public Health and Health Services03 medical and health sciencesFEV1/FVC ratioMendelian randomizationLUNG-FUNCTION DECLINEMendelian randomizationQUALITYHumansCOPDGENOME-WIDE ASSOCIATION030304 developmental biologyScience & Technologybusiness.industryPublic Health Environmental and Occupational Healthnutritional and metabolic diseaseslung functionADULTSMendelian Randomization Analysismedicine.diseaseCross-Sectional Studies030228 respiratory systemASTHMAbusinessFOLLOW-UPBody mass indexDemographyFrontiers in Public Health
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Respiratoro alerģisko reakciju novērtējums Latvijas populācijā

2016

Pasaulē saslimstība ar alerģijām aizvien turpina pieaugt. No dažādām alerģiskām slimībām cieš aptuveni 30 – 40% pasaules iedzīvotāju. Respiratorās alerģijas ir biežāk sastopamās alerģijas formas. Zināms, ka no alerģiska rinīta pasaulē cieš aptuveni 5 – 50% populācijas, bet no bronhiālās astmas 5 – 12%. Par maģistra darba pētījuma mērķi izvirzījām, izmantojot Paula Stradiņa Klīniskās universitātes slimnīcas plaušu funkcionālās diagnostikas kabineta datu bāzi, noskaidrot kādi ir biežākie alergēni Latvijas populācijā, kas izraisa respiratorās alerģijas un kādi medikamenti visbiežāk tiek izmantoti to terapijai. Tika noskaidrots, ka biežākie alergēni Latvijas populācijā, kas izsauc respiratorās …

alerģiskais rinītsallergic rhinitisbronhiālā astmaFarmācijabronchial asthmaalergēni
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The effect of allergen immunotherapy in the onset of new sensitizations: a meta-analysis.

2017

Background Although the preventive efficacy of allergen immunotherapy (AIT) in the onset of new allergen sensitizations has been asserted by many reviews, position papers, and consensus conferences, the evidence available is from only 3 studies. The objective of this work was a systematic review to evaluate the preventive efficacy of AIT in the onset of new allergen sensitizations. The end-point was the risk difference (RD) in the onset of new allergen sensitizations between patients treated with AIT and pharmacotherapy. Methods Computerized bibliographic searches of MEDLINE, EMBASE, and the Cochrane Library (until November 30th, 2016) were done. Random-effects and fixed-effects model meta-…

allergic rhinitisPyroglyphidaenew allergen sensitizationasthmameta-analysiDesensitization ImmunologicAnti-Allergic Agentsallergen immunotherapyHypersensitivityAnimalsHumansImmunizationAntigens DermatophagoidesChildRandomized Controlled Trials as TopicInternational forum of allergyrhinology
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Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA-ARIA-EPOS-AIRWAYS IC…

2017

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging dat…

allergic rhinitis; integrated care pathway; precision medicine; rhinosinusitisAllergyRhinosinusitisDiseaseAllergic rhinitis0302 clinical medicineQUALITY-OF-LIFEMedicineImmunology and Allergy030223 otorhinolaryngologySinusitisNASAL POLYPOSISRhinitisPrecision medicineintegrated care pathway3. Good healthAlgorithmREAL-LIFEIMPACT OUTCOMESARIA and EPOS working groups1107 ImmunologyDISEASESGA(2)LENDisease Progressionallergic rhinitiLife Sciences & BiomedicineENDOSCOPIC SINUS SURGERYAlgorithmsHumanIntegrated care pathwayallergic rhinitis; integrated care pathway; precision medicine; rhinosinusitis; Adult; Algorithms; Chronic Disease; Disease Progression; Humans; Precision Medicine; Rhinitis Allergic; Sinusitis; Young Adult; Immunology and Allergy; ImmunologyAdultmedicine.medical_specialtyprecision medicineImmunologyrhinosinusitiPHENOTYPESVALIDATIONYoung Adult03 medical and health sciencesTherapeutic approachAllergicPatient satisfactionQuality of life (healthcare)HumansSinusitisPatient participationIMMUNOTHERAPYIntensive care medicinerhinosinusitisAsthmaScience & Technologyallergic rhinitis; integrated care pathway; precision medicine; rhinosinusitis; Immunology and Allergy; Immunologyallergic rhinitisbusiness.industrymedicine.diseasePrecision medicineSinusitiRhinitis AllergicSEVERITY030228 respiratory system3121 General medicine internal medicine and other clinical medicineChronic DiseasePhysical therapyASTHMAbusiness
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Bronhiālās astmas ārstēšanai izmantojamo medikamentu aprite "Benu aptiekā 2" 2015. gadā

2016

Astma ir izplatīta hroniska elpceļu iekaisuma slimība, kas skar gan bērnus, gan pieaugušos. To raksturo mainīgi un atkārtoti simptomi, atgriezeniska elpceļu obstrukcija un bronhu spazmas. Astmas ārstēšanas mērķis ir iegūt klīnisko kontroli un samazināt nākotnes risku pacientam. Šī darba mērķis ir izpētīt bronhiālās astmas ārstēšanai izmantojamo medikamentu apriti Benu aptiekā 2 Rīgā 2015. gadā un to atbilstību Global Initiative for Asthma (GINA) 2016. gada vadlīnijām. Astmas terapijā ārsti visbiežāk izraksta astmas kontrolējošos medikamentus. Pieprasītākais astmu kontrolējošais medikaments ir inhalējama glikokortikoīda un ilgstošas darbības β2 agonista kombinētais medikaments flutikazons/ s…

aprite/ turnoverFarmācijamedikamenti/ mediacationsastma/ asthmaaptieka/ pharmacy
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