Search results for "Asymmetric"
showing 10 items of 241 documents
Catalytic Asymmetric Formal [3+2] Cycloaddition of 2-Isocyanatomalonate Esters and Unsaturated Imines: Synthesis of Highly Substituted Chiral γ-Lacta…
2017
[EN] Unlike their isocyano and isothiocyanato analogues, isocyanato esters remain almost unexplored as formal 1,3-dipoles in asymmetric catalytic reactions. The first asymmetric formal [3+2] cycloaddition involving isocyanato esters and electrophilic alkenes is reported. Diisopropyl 2-isocyanatomalonate reacts with a,b-unsaturated N-(o-anisidyl) imines in the presence of a Mg(OTf)2¿BOX complex to give highly substituted chiral pyrrolidinones featuring a conjugate exocyclic double bond with excellent yields and enantiomeric excesses up to 99%. Several transformations of the resulting heterocycles, including the synthesis of a pyroglutamic acid derivative, have been carried out.
Analysis of hazardous chemicals by “stand alone” drift tube ion mobility spectrometry: a review
2020
Ion mobility spectrometry (IMS) is a widely used technique based on gas phase ion separation under an electric field by differences in ion mobilities. In the last decade, IMS techniques have received increased attention due to their high operational speed and sensitivity. Currently, there are different IMS devices focused on solving different analytical performances, mainly based on linear drift tube (DT IMS), traveling wave, and field asymmetric waveform ion mobility spectrometers. In this review we summarize the main applications of DT-IMS devices for the determination of semi-volatile hazardous chemicals such as: illegal drugs, pesticides, explosives, chemical warfare agents, and others,…
Performance Comparison of Electrical Motors equipped with slightly Asymmetrical Windings
2019
This paper presents a comparison between the performances of electrical machines equipped with slightly asymmetrical windings. More in detail, by modifying the stator geometry of an Interior Permanent Magnet Synchronous Machine equipped with a symmetrical winding configuration, other two slightly asymmetrical winding topologies are obtained. The three models are, then, analyzed by means of a finite element method (FEM) and the related results are compared in terms of cogging torque, static characteristics and leakage factor. The obtained results demonstrate that the adoption of slightly asymmetrical windings could be an interesting alternative solution during the design stage of electrical …
Experimental and theoretical insights in the alkene-arene intramolecular π-stacking interaction
2016
Chiral acrylic esters derived from biomass were developed as models to have a better insight in the aryl-vinyl π-stacking interactions. Quantum chemical calculations, NMR studies and experimental evidences demonstrated the presence of equilibriums of at least four different conformations: π-stacked and face-to-edge, each of them in an s-cis/s-trans conformation. The results show that the stabilization produced by the π-π interaction makes the π-stacked conformation predominant in solution and this stabilization is slightly affected by the electron density of the aromatic counterpart. Fil: Corne, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológi…
The p21-activated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation
2013
The final size of the central nervous system is determined by precisely controlled generation, proliferation and death of neural stem cells. We show here that the Drosophila PAK protein Mushroom bodies tiny (Mbt) is expressed in central brain progenitor cells (neuroblasts) and becomes enriched to the apical cortex of neuroblasts in a cell cycle- and Cdc42-dependent manner. Using mushroom body neuroblasts as a model system, we demonstrate that in the absence of Mbt function, neuroblasts and their progeny are correctly specified and are able to generate different neuron subclasses as in the wild type, but are impaired in their proliferation activity throughout development. In general, loss of…
Measuring of Geometrical Precision of Some parts Obtained by Asymmetric Incremental Forming Process After Trimming
2007
Asymmetric Incremental Forming exalts the advantages of Incremental Forming process since no dies are strictly necessary. In this way complex geometries may be manufactured with a very simple clamping equipment. On the other hand, this characteristic determines some intrinsic drawbacks which penalise its industrial suitability; first of all, the dimensional control of the manufactured part is a still open point for researchers all over the world. Several approaches have been already proposed in the last years to solve the problem, resulting only in partial solutions. At the same time, up to now, the numerical simulation did not supply significant aid to the designers, due to the problem com…
Ethics in military organisations : implementation in the battlefield and lessons for management sciences
2016
This research questions the idea of military ethics. Our work uses an analytical framework combining three different disciplines: Ethics of care, developed in moral philosophy, Stakeholder theory, from business ethics, New institutionalism theory, from management science. This framework is then applied on two different research fields: the first one deals with the study of battles where ethical stakes were particularly high: the battle of Alger, the Iraqi war, the Srebrenica battle.The second one is qualitative interviews with officers coming back from the battlefield: 10 US officers from the Iraqi conflict and 7 French militaries from Afghanistan. These two research fields are completed by…
How endogenous asymmetries in interregional market access trigger regional divergence
2005
International audience; We investigate how asymmetric trade patterns in differentiated products affect the regional distribution of economic activities. The asymmetry in interregional market access is an endogenous result of price competition and industry location and arises for intermediate values of trade costs. We show that the emergence of one-way trade in differentiated products gives rise to strong agglomeration forces and leads to the absorption of the smaller region's industry by the larger region. The number of spatial equilibria increases once the pattern of trade is endogenously accounted for.
Silent and symptomatic atrial fibrillation,during the acute phase of myocardial infarction : determinants and role of arginine methylated and oxidati…
2015
Atrial fibrillation (AF) is a frequent complication of acute myocardial infarction (AMI) with a poorer prognosis. Silent atrial fibrillation has been suggested to be frequent after AMI. However, most part of the studies has targeted only paroxysmal or persistent AF. Thus, Reduced Nitric Oxide availability and endothelial dysfunction has been recently recognized as a possible contributor to altered prognosis in AF. Asymmetric dimethylarginine (ADMA) can inhibit nitric oxide synthase and leads to endothelial dysfunction, inflammation and oxidative stress in multiple cardiovascular diseases. However, any study has addressed the relationship between ADMA levels and the occurrence of AF in AMI.W…