Search results for "Atrial"

Atrial Natriuretic Peptide presence in parotid gland of human fetus at 13th week of development and in adult man

2013

Our immunohistochemical study shows that atrial natriuretic peptide (ANP) is present in both human fetal and adult parotid gland. In the fetuses ANP is localized in cell clusters, while in adult parotid gland, the ANP is seen only in the wall of intra- and extralobular ducts. The results suggest that ANP might play a role in the differentiation of the parotid gland similarly as in brain and that during fetal growth ANP may play a role in the regulating the secretion of primitive salivary fluid, even if acini are still not developed. (Folia Histochemica et Cytobiologica 2013, Vol. 51, No. 1, 55-58)

Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin…

2011

Full-term human umbilical cord contains three blood vessels: two arteries coiled around a vein and surrounded by Wharton’s jelly, a mucous tissue with few mesenchymal stromal cells and abundant extracellular matrix. Umbilical vessels lack innervations, thus endothelial cells must play a role in the control of blood flow. The aim of this study was to investigate in human umbilical cord the expression of five peptides that could be involved in the regulation of vascular tone: Orphanin FQ, Oxytocin, Atrial Natriuretic Peptide (ANP), endothelial Nitric Oxide Synthase (eNOS) and inducible Nitric Oxide Synthase (iNOS). The expression of these molecules in full-term human umbilical cord …

Immunohistochemical and Biomolecular Identification of Orphanin FQ, eNOS, Atrial natriuretic Factor and Oxytocin in Rat Seminal Vesicles

2009

In previous studies performed on rodents, we detected the presence of adreno-cholinergic and peptidergic innervation in seminal vesicles and other organs of the male genital system, such as prostate and ductus deferens, in which we also investigated the expression of NOS and NADPH-diaphorase. During the present project we focused our attention on the expression of some peptides involved in local control of smooth muscle relaxation, contractility, vasodilatation and control of blood flow in rat seminal vesicles. We investigated, through immunohistochemistry and RT-PCR, the presence of four peptides: orphanin, eNOS, ANF and oxytocin. Immunohistochemistry was used to detect the presence of the…

ANP differentiates between primary Submandibular Gland Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: Preliminary data

2021

The natriuretic peptide system consists of three ligands, Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors (NPR’s), NPRA, NPRB and NPRC. We investigated the expression levels of NPPA (encoding ANP) and NPR1 (encoding NPRA, the main receptor for ANP) in primary benign (pleomorphic adenoma) and malignant (squamous cell carcinoma, SCC) submandibular salivary gland (SMG) tumors, as well as in primary oral squamous cell carcinoma (OSCC). We found that the NPPA and NPR1 expression levels were significantly different in SMG SCC versus OSCC, exhibiting a significant increase in NPPA and absence of NPR1 ex…

Atrial natriuretic peptide (ANP) and oxytocin-expression in the adult rat and mouse cerebellum.

2015

Abstract Background: Many studies are in the literature on the ANP and oxytocin-presence in the brain, but very few studies with controversial results are reported on the presence of these peptides in the cerebellum. This immunohistochemical study investigates on the ANP and oxytocin-presence in the cerebellum of the adult rat and mouse rodents. Results: This study, firstly, evidences the ANP- immunopositivity in cerebellar cortex of both rat and mouse rodents. In rat the molecular layer presents some few immunopositive fibers, but no neuron resulted immunopositive; the granular and Purkinje cells are immunopositive. In mouse the cerebellar cortex ANP-immunopositivity is present in all laye…

The Role of Patient-Specific Morphological Features of the Left Atrial Appendage on the Thromboembolic Risk Under Atrial Fibrillation

2022

BackgroundA large majority of thrombi causing ischemic complications under atrial fibrillation (AF) originate in the left atrial appendage (LAA), an anatomical structure departing from the left atrium, characterized by a large morphological variability between individuals. This work analyses the hemodynamics simulated for different patient-specific models of LAA by means of computational fluid–structure interaction studies, modeling the effect of the changes in contractility and shape resulting from AF.MethodsThree operating conditions were analyzed: sinus rhythm, acute atrial fibrillation, and chronic atrial fibrillation. These were simulated on four patient-specific LAA morphologies, each…

A GENETIC VARIANT OF THE ATRIAL NATRIURETIC PEPTIDE GENE IS ASSOCIATED WITH CARDIOMETABOLIC PROTECTION IN THE GENERAL COMMUNITY

2011

A particular bigeminy during atrial tachycardia, part II

2014

Joint use of cardio-embolic and bleeding risk scores in elderly patients with atrial fibrillation.

2013

VALUTAZIONE DEI MARKERS INFIAMMATORI E DEGLI INDICI DI DISFUNZIONE ENDOTELIALE IN UNA POPOLAZIONE DI PAZIENTI CON FIBRILLAZIONE ATRIALE PERMANENTE CO…

2022

Negli ultimi anni un numero crescente di studi ha sostenuto il ruolo dell'infiammazione nell'inizio, nel mantenimento e nell'outcome della fibrillazione atriale (FA). Tuttavia, nonostante una grande quantità di informazioni, è ancora oggetto di discussione se la fibrillazione atriale o la cardiopatia strutturale sottostante (SHD) sia la causa del processo infiammatorio. Abbiamo quindi cercato di determinare se il processo infiammatorio riflette una malattia sottostante o l'aritmia "di per sé". Pertanto abbiamo valutato i livelli plasmatici del recettore alfa solubile dell'interleuchina 2 (sIL-2Rα), TNF-α e IL-18 in una coorte di 100 pazienti con FA permanente arruolati consecutivamente (43 …