Search results for "Atypical"
showing 10 items of 111 documents
PM441. Long term atypical antipsychotic treatment improves cognitive performance in schizophrenia but not surpassing conventional antipsychotic drugs…
2016
Autofluorescence imaging of basal cell carcinoma by smartphone RGB camera
2015
The feasibility of smartphones for in vivo skin autofluorescence imaging has been investigated. Filtered autofluorescence images from the same tissue area were periodically captured by a smartphone RGB camera with subsequent detection of fluorescence intensity decreasing at each image pixel for further imaging the planar distribution of those values. The proposed methodology was tested clinically with 13 basal cell carcinoma and 1 atypical nevus. Several clinical cases and potential future applications of the smartphone-based technique are discussed.
Diagnoses as Selection Criteria in Drug Trials
1990
Drug trials are needed to establish the efficacy and safety of psychopharmacological agents in clearly defined indications. When the goal of treatment is more complex than removal of an isolated symptom (“difficulty in falling asleep” or “pain”) the syndrome or clinical entity to be treated is most easily classified by way of a diagnostic label (like “depression,” “schizophrenia,” or “panic disorder”). Dimensional models have many advantages: they often fit the data better and provide a conceptual framework for a continuum in the behavior from normal to abnormal. However, they have never reached the popularity of typological models (Strauss 1973, 1975, 1986) which reflect more the medical t…
Atypical epithelial hyperplasia of the breast: state of the art.
2016
International audience; Introduction: Atypical epithelial hyperplasia (AEH) of the breast is considered benign histological lesions with breast cancer risk. This review focuses on clinical signification and management of AEH that remains controversial. Areas covered: A review of published studies was performed using medline database. In this review, we fully describe the current evidence available. In particular, we describe 1) data from immunohistochemistry and molecular studies that suggest AEH is a precursor of breast cancer; 2) epidemiological studies demonstrate low rate of breast cancer in women with AEH; 3) surgical excision is necessary after diagnosis of AEH, such as lobular carcin…
Central Serotonin2C Receptor: From Physiology to Pathology
2006
Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has…
Chaperons moleculae in brain tumors-CHAMOBRAT TRIAL: HSP60 and microRNAs related levels in tissue and circulating exosomes in human brain tumors befo…
Current regimen for high-grade gliomas is maximal safe surgical resection followed by external beam radiotherapy with concurrent temozolamide. Maximal tumor resection, however, must be balanced with preservation of the patient’s neurological function. A crucial prognostic factor in oncological neurosurgery is the extent of resection. Several studies have addressed the importance of extent of resection in gliomas surgery. Despite development in the fields of pre operative and intraoperative neuroimaging and neuromonitoring have ameliorated the survival rate and the quality of life for patients affected by high grade gliomas, the clinical outcome of patients with such gliomas remains extremel…
Temas e interpretaciones del derecho sucesorio italiano
2021
El articulo quiere mostrar que las interpretaciones de las instituciones del derecho de sucesiones que consideran el interés familiar, como expresión del principio de solidaridad (cada vez más en una protección patrimonialista de la legitimidad), siempre prevalente sobre todos los demás intereses, ya no pueden ser compartidas, porque la solidaridad no se distingue del personalismo. Modernizar el derecho de sucesiones no significa tener que abdicar en favor del contrato, sino descubrir el valor de la autonomía privada y el potencial del acto de última voluntad. Es la centralidad de la persona humana y no sólo el principio de solidaridad (más aún si se entiende en un sentido patrimonialista) …
Typically and Atypically Developing Children' Generalizations of Novel Names: the Role of Semantic Distance
2019
International audience; Children often learn the extension of novel words with a limited number of exemplars. There is evidence that the opportunity to compare stimuli is beneficial for learning and generalizing novel names in typically developing (TD) children (e.g., Gentner, 2010). However, so far,, comparison situations have not been studied in children with intellectual disabilities (ID) (Chapman & Kay-Raining Bird, 2012). This is important since they are in need of well-devised learning situations. We manipulated the role of semantic distance within training stimuli and between training and test stimuli and their influence on taxonomically-based generalization. We hypothesized more dif…
Anterior cervical discectomy and fusion is more effective than cervical arthroplasty in relieving atypical symptoms in patients with cervical spondyl…
2022
Background and purpose Patients with cervical spondylosis often present with concurrent 'atypical symptoms' of unknown etiology that have been associated with cervical spondylotic disease, including dizziness, headache, nausea, tinnitus, blurred vision, palpitations, and memory and gastrointestinal disturbances. Few studies have addressed whether surgical intervention to treat classic symptoms of cervical spondylosis can also effectively alleviate atypical symptoms. Accordingly, the purpose of this study is to compare the ability of cervical arthroplasty (CA) and anterior cervical discectomy and fusion (ACDF) to alleviate atypical symptoms associated with cervical spondylosis. Materials and…
Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
2022
Total hysterectomy and bilateral adnexectomy is the standard treatment for atypical endometrial hyperplasia and early-stage endometrial cancer. However, the recommended surgical treatment precludes future pregnancy when these conditions are diagnosed in women in their fertile age. In these patients, fertility-sparing treatment may be feasible if the desire for childbearing is consistent and specific conditions are present. This review summarizes the available evidence on fertility-sparing management for atypical endometrial hyperplasia and early-stage endometrial cancer. Historically, oral progestins have been the mainstay of conservative management for atypical endometrial hyperplasia and …