Search results for "Author"

Regulatory evaluation of Glybera in Europe — two committees, one mission

2013

Representing the first gene therapy to be approved in the Western world, alipogene tiparvovec (Glybera; Uniqure) has recently been said to have had a “substantial impact from a regulatory perspective” (Nature Rev. Drug Discov. 11, 664; 2012) 1 . The therapy was granted marketing authorization in the European Union for the treatment of lipoprotein lipase deficiency, which results in a clinically heterogeneous condition with a risk of potentially life-threatening pancreatitis 2 , at the end of 2012. The decision followed a positive opinion by the European Medicines Agency (EMA)’s Committee for Medicinal Products for Human Use (CHMP) 3

Who sent the e-mail?

2003

In mid October 2001, a number of lecturers at the University of Valencia received insulting, threatening and anonymous electronic mails. An investigation about this fact is only permitted under very restricted conditions, stipulated by the Spanish law of the Secrecy of Communications. Only one judicial authority is able to lift these restrictions and authorize information to be checked in order to obtain enough evidence to unveil who was responsible for the messages. The authors propose in this paper a study for quantifying the weight of certain evidence with a view to show to the judge that the relevance of the said weight would justify such a measure.

On the Epistemic Authority of Experience

2009

SWIFT J1756.9-2508: spectral and timing properties of its 2018 outburst

2018

We discuss the spectral and timing properties of the accreting millisecond X-ray pulsar SWIFT J1756.9-2508 observed by XMM-Newton, NICER and NuSTAR during the X-ray outburst occurred in April 2018. The spectral properties of the source are consistent with a hard state dominated at high energies by a non-thermal power-law component with a cut-off at ~70 keV. No evidence of iron emission lines or reflection humps has been found. From the coherent timing analysis of the pulse profiles, we derived an updated set of orbital ephemerides. Combining the parameters measured from the three outbursts shown by the source in the last ~11 years, we investigated the secular evolution of the spin frequency…

Discrimination of LINAC photon and sunlight contributions in watch glass analyzed by means of thermoluminescence

2012

Abstract The research described in this paper shows how to extract from the glow curves of watch glasses exposed to LINAC photons and sunlight a contribution sensitive to LINAC photons dose. As first step, the dependence of the TL signal due to sunlight on the exposure duration was studied and a signal saturation was observed after about 20 weeks. The comparison of TL signals due to solar light and to LINAC photons highlights a partial overlap of the two signals. Here, two different analysis procedures of glow curves (general order kinetics deconvolution and principal components analysis) are reported to point out components which depend differently on LINAC photon radiation dose. For both …

How to read a recipe: the semiotic point of view

2020

Writing a recipe is no easy task. It requires great care to render those various steps clearly, placing them in order, explaining the reasons for their importance in achieving the final result. However, over time the technique for writing a recipe, and consequently for composing an entire recipe book, has not just been perfected, but has reached fairly stable standards that, when reproduced, make teaching others to cook using the written word a fairly common practice. So, this article try to answer to the answers: How are recipes structured? What order do they follow when describing a culinary procedure?

Estilo y autoría en la información. Una aparente ausencia de identidad

2009

Dolors.Palau@uv.es Los textos periodísticos son un reflejo de los diversos estilos, de la diversidad de formas de ver y construir la realidad de los periodistas que los elaboran. Más allá de la prescripción y las posturas acríticas que han presidido la reflexión sobre estas cuestiones, este artículo aboga por un análisis que saque a la luz los mecanismos lingüísticos en los que se refleja el punto de vista, las estrategias que subyacen a una aparente ausencia de identidad, a una autoría pretendidamente enmascarada. Para ello parte de una revisión pluridisciplinar de los conceptos de estilo y autor, antes de proponer y aplicar un método de análisis pragmaestilístico. Journalistic articles ar…

Poezja Zaolzia : szkic

2017

The sketch on poetry of Zaolzie is an attempt to analyze the leading authors in the region in the years 1920-2016. The period was divided into sub-periods: the interwar years - the period of creative activity of such poets as K. Berger, O. Zawisza, L. Kobiela and the debutants: A. Fierla, P. Kubisz, J. Ondrusz, G. Przeczek, J.S. Polaczek. In the year 1936, there was established the Section of Literature and Art at Macierz Szkolna [Polish Schools Organization], which aimed to formally protect Polish artistic activity in Zaolzie. This did not satisfy the expectations of young creators, though, and therefore a year later there was founded Śląski Związek Literacko-Artystyczny [Silesian Literary…

Reglamentowana odwilż. Obóz „zamkowy” na emigracji wobec wydarzeń w Polsce i bloku komunistycznym w 1956 roku

2016

The article presents the position of “the Castle” on emigration (the President, government and the Council of the Republic of Poland) towards the events in Poland and the Eastern Bloc in 1956. The politicians and publicists of “the Castle”, observing some changes in the country, did not expect that they would lead to basic changes. The opinion prevailed that Poland was not an independent state and that the Soviet occupation still persisted. Propagating maximum demands (independence, restoration of the pre-war border in the east), they did not have much hope in an evolutionary course of changes. They opted for a deposition, and not a liberalisation of the communist system in Poland and the r…

Opening the can of worms: A comprehensive examination of authoritarianism

2020

Abstract We carry out an exhaustive analysis of both right-wing and left-wing forms of authoritarianism in order to assess the specific predictors of these illiberal agendas. Firstly, we conduct a literature review on authoritarianism as a multidimensional psychological construct, with emphasis on its controversial links to the political spectrum, religion, and economic conservatism. Moreover, we review its potential associations with social axioms, as an interesting psychological framework to aid understanding of authoritarian attitudes. We extract three working hypotheses from this literature review, all successfully tested in two empirical studies (n = 1097 and n = 1102). Our results sug…