Search results for "Availability"
showing 10 items of 510 documents
Quantitative assessment of the parameters linked to the blending between reclaimed asphalt binder and recycling agent: A literature review
2020
Abstract The lack of understanding the mechanisms governing the interaction between reclaimed asphalt binder (RAb) 1 and recycling agents is one of the technical issues that still need to be resolved when high amount of reclaimed asphalt (RA) 2 is used in a new recycled asphalt mixture (RAM). Due to important role of RAb in that interaction and increased used of RA, it becomes necessary to have a way to classify RA, as any other material used in asphalt mixture production. It is very important to determine how much RAb is active by itself (DoA) 3 , but also to determine how much RAb can be considered available for a mix design of RAM (DoAv) 4 when a recycling agent is used. Finally, since t…
ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability.
2020
In silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development. However, the high variability and complexity of oral bioavailability and the limited experimental data in the public domain have mainly restricted the development of reliable in silico models to predict this property from the chemical structure. In this study we present a KNIME automated workflow to predict human oral bioavailability of new drug and drug-like molecules based on five machine learning approaches combined into an ensemble model. Th…
SREP: An Energy Efficient Relay Protocol for Wireless Sensor Networks
2018
While wireless sensor networks continue to break new grounds in applications, favored by technological innovations, energy efficiency continues to stagnate. Duty cycling remains the most popular and effective technique used to improve energy efficiency and thus lifetime of the network. Nevertheless, duty cycling imposes temporary unavailability on the network leading to deterioration of quality of service. To take care of this rather contradicting reality, this paper proposes Sleep Relay Protocol (SREP). Network nodes are divided into sets according to their location and the sets sleep in relay within a duty cycle period. Two set formation algorithms are proposed at initiation of our propos…
Real-Time Power Flow Monitoring and Control System for Microgrids Integration in Islanded Scenarios
2019
This article presents an enhanced system for real-time power flow monitoring and control (PFMC) for microgrids integration in medium-voltage (MV) distribution networks. The developed solution includes both system architecture and the monitoring and control algorithms, and it has low implementation and installation costs. It is based on the use of hardware and software solutions previously proposed by the authors, i.e., a distributed measurement, a control and communication architecture, and a supervisory control and data acquisition (SCADA) software, which have been enhanced and integrated for the considered application. The SCADA implements a load flow (LF) algorithm for real-time power fl…
Energy saving in WWTP: Daily benchmarking under uncertainty and data availability limitations
2016
Efficient management of Waste Water Treatment Plants (WWTPs) can produce significant environmental and economic benefits. Energy benchmarking can be used to compare WWTPs, identify targets and use these to improve their performance. Different authors have performed benchmark analysis on monthly or yearly basis but their approaches suffer from a time lag between an event, its detection, interpretation and potential actions. The availability of on-line measurement data on many WWTPs should theoretically enable the decrease of the management response time by daily benchmarking. Unfortunately this approach is often impossible because of limited data availability. This paper proposes a methodolo…
Research on children's lexical availability: applications for SFL teaching
2022
Esta investigación presenta la aportación que la disponibilidad léxica tiene en el marco de la enseñanza de Español como Lengua Extranjera y el ámbito infantil. Para poder desarrollar esta tarea se ha realizado una revisión bibliográfica sistemática que presenta a aquellos trabajos publicados sobre léxico disponible. A partir de los resultados obtenidos se ha observado una baja incidencia de investigaciones sobre ELE con población escolar (hasta 12 años), en comparación con corpus adultos. En segundo lugar, también se han localizado, a parte de los dieciséis centros de interés tradicionales, treinta áreas complementarias o novedosas que coinciden con las clasificaciones desarrolladas por el…
Bioaccessibility of bioactive compounds after non-thermal processing of an exotic fruit juice blend sweetened with Stevia rebaudiana
2017
Abstract A comparative study of the bioaccessibility of bioactive compounds and antioxidant capacity in a fruit juice-Stevia rebaudiana mixture processed by pulsed electric fields (PEF), high voltage electrical discharges (HVED) and ultrasound (USN) technology at two equivalent energy inputs (32–256 kJ/kg) was made using an in vitro model. Ascorbic acid was not detected following intestinal digestion, while HVED, PEF and USN treatments increased total carotenoid bioaccessibility. HVED at an energy input of 32 kJ/kg improved bioaccessibility of phenolic compounds (34.2%), anthocyanins (31.0%) and antioxidant capacity (35.8%, 29.1%, 31.9%, for TEAC, ORAC and DPPH assay, respectively) compared…
In vitro digestion of two age-tailored dairy products in the aging gastrointestinal tract
2023
For older adults (> 65 years old), undernutrition is a severe health problem that can impact the quality of life, induce or aggravate the development of diseases, and reduce life expectancy. Undernutrition can be defined as an inadequate intake of dietary energy and proteins combined with a low muscle mass. Diet-induced muscle mass and strength loss in older adults may be due to insufficient protein intake. Therefore, older adults need to increase the amount of high-quality ingested proteins, particularly foods rich in leucine, to promote muscle health. However, it is still unclear if changes in protein digestibility and absorption kinetics in old age may affect the anabolic effect of high-…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with…
2020
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinetic (PBPK) models integrate all available information on gastro-intestinal system with drug and formulation data to predict oral drug absorption. The latter together with in vitro-in vivo extrapolation and other preclinical data on drug disposition can be used to predict plasma concentration-time profiles in silico. Despite recent successes of PBPK in many areas of drug development, an improvement in their utility for evaluating oral absorption i…
Apple-products phytochemicals and processing: a review.
2009
Epidemiological studies have linked the consumption of apples with reduced risk of some cancers, cardiovascular disease, asthma, and diabetes. Extensive research exists on apples and the health benefits of their beverages and phytochemicals. The purpose of this paper is to review the most recent literature in this area focusing on phytochemicals, phytochemical bioavailability and antioxidant behavior.