Search results for "Aves"

Optimizing intravesical chemotherapy in patients with non muscle invasive bladder carcinoma.

2008

Re: Urinary pH is Highly Associated With Tumor Recurrence During Intravesical Mitomycin C Therapy for Nonmuscle Invasive Bladder Tumor

2011

The authors should be congratulated for their attention to basic and open questions on intravesical therapy of nonmuscle invasive bladder cancer. Intravesical delivery of chemotherapy remains partly empirical, and the pharmacokinetics poorly understood. Every attempt to optimize intravesical therapy should be welcomed. Expensive new strategies to deliver an effective therapeutic tumor dose are currently being explored.1,2 It is reasonable (and mandatory) first to consider and study the basic principles of pharmacokinetics. In this retrospective study Maeda et al investigate the role of pH on the efficacy of intravesical mitomycin C (MMC) in vivo. Their experience shows that urinary pH highe…

Adjuvant intravesical therapy in intermediate risk non-muscle invasive bladder cancer (NMIBC) recurring after first cycle of intravesical treatment.

2011

Introduction and objectives The therapeutic management of intermediate risk NMI-BC recurring after intravesical therapy (IT) is not established. Cystectomy will be offered to patients at higher risk of progression but the majority will be retreated by IT. Although some Authors suggest BCG when intravesical chemotherapy (ICH) fails, some patients are retreated by ICH and some others repeat BCG adopted as first-line treatment. Not many studies have been published on this issue. The response to retreatment by intravesical therapy in terms of recurrence-free rate (RFR) and recurrence-free survival (RFS) is analyzed in 179 intermediate-risk patients. Materials and methods Only intermediate-risk …

A phase I-II study on intravesical Gemcitabine in superficial bladder papillary tumors

2004

INTRODUCTION AND OBJECTIVE: The possible role of gemcitabine inintravesical therapy of superficial transitional cell carcinoma of the bladder (TCCB) has been suggested. The European Organization for Research and Treatment of Cancer Urological Group validated the use of papillary marker lesion left in the bladder after TUR as the best tool to measure the efficacy of a drug by intravesical route against TCCB. The rsults on 27 patients are herein presented. METHODS: Twenty-seven patients, with recurrent superficial TCCB (Ta-T1, G1-G2), were treated with intravesical gemcitabine for 1 to 3 papillary marker lesions (5-15 mm) left unreseacted after TUR. Twenty-one patients (78%) had recurrent tum…

The groundwater pollution of Korneuburg, Austria : its issue life-cycle in the public discourse and collaboration and confrontation strategies of act…

2015

This thesis is a case study about the groundwater contamination of Korneuburg, Austria. The company Kwizda was responsible for pesticides leaking into the groundwater. The contamination was kept quiet with the help of local authorities and would have never come to light if not for the diligent efforts of affected residents. Their collaboration with environmental activists and a journalist led to the uncovering of the incident, eventually leading to remediation measures and lawsuits. While public attention to the issue was high, the authorities approved a controversial remediation measure that would lead to further pollution. With a particular reference to environmental and social issues, th…

Step-by-step analysis of drinking water treatment trains using size-exclusion chromatography to fingerprint and track protein-like and humic/fulvic-l…

2019

This paper provides a glimpse into the removal of dissolved organic matter (DOM) during conventional drinking water treatment and evaluates the potential of high-performance size-exclusion chromatography (HPSEC) as a supplementary tool for routine monitoring of drinking water treatment plants (DWTPs). Two DWTPs in Central Finland were systematically evaluated using HPSEC with simultaneous UV and fluorescence detection. For tyrosine-like, tryptophan-like, and humic/fulvic-like DOM fractions of various molecular weight (MW) values, the total and step-by-step removal efficiencies were estimated along the treatment trains. Overall, both DWTPs removed ∼70% of dissolved organic carbon (DOC) and r…

Occurrence of pharmaceuticals in municipal wastewater treatment plants and receiving surface waters in Central and Southern Finland

2016

The presence of five selected pharmaceuticals, four anti-inflammatory drugs, diclofenac, ibuprofen, ketoprofen, naproxen, and an antiepileptic drug carbamazepine, was determined at four municipal wastewater treatment plants (WWTPs) and in the receiving waterway near the city of Jyväskylä, in central Finland and also in the River Vantaa. First, an analytical method was developed including a pretreatment and purification followed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in the multiple reaction monitoring mode. The studied pharmaceuticals were detected from influents and effluents of four municipal WWTPs and from surface water of eight locations along the water …

Kaatopaikkakaasun puhdistaminen liikennepolttoaineeksi vastavirtavesiabsorptiolla

2007

Occurrence and control of selected antibiotics and antiretroviral drugs in urban hydrological cycles

2018

N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

2015

Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cel…