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RESEARCH PRODUCT
N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis
Paul A. FitzpatrickGöran LandbergJoseph NdanuMáté ErdélyiJoan J. E. MunissiBin WangStephen S. NyandoroYu LuFangfang PanKari RissanenAmra Gruhonjicsubject
kemiaToussaintia orientalismedicine.drug_classAntitubercular AgentsPharmaceutical ScienceAnnonaceaeMicrobial Sensitivity TestsAntimycobacterialchemistry01 natural sciencesHigh-performance liquid chromatographyTanzaniaAnalytical ChemistryMycobacterium tuberculosischemistry.chemical_compoundColumn chromatographyDrug DiscoverymedicineHumansTriple negativeNuclear Magnetic Resonance Biomolecularta116PharmacologyChromatographybiologyStrain (chemistry)Molecular Structure010405 organic chemistryCyclohexanonesOrganic ChemistryMycobacterium tuberculosisbiology.organism_classificationtoussaintia orientalis0104 chemical sciences3. Good healthPlant Leavesn-cinnamoyltetraketide010404 medicinal & biomolecular chemistryComplementary and alternative medicinechemistryCinnamatesMolecular MedicineFemaleMethanolDrug Screening Assays Antitumordescription
Seven N-cinnamoyltetraketides (1−7), including the new Ztoussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3−107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3−105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Journal of Natural Products |