Search results for "Axe"

Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.

2016

To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies are needed in which physicochemical and pharmaceutical properties can be tailored according to specific medical needs and applications. We here systematically customized the properties of core-crosslinked polymeric micelles (CCPM). The micelles were based on mPEG-b-pHPMAmLacn (i.e. methoxy poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]), similar to the block copolymer composition employed in CriPec® docetaxel, which is currently in phase I clinical trials. The CCPM platform was tailored with regard to size (30 to 100 nm), nanocarrier degradation (1 month to 1 year) and drug…

LA SCALA A. E., EU-Taxes - Taxing competences within the legal framework of the European Community, national report for Italy, Kluwer International, …

2008

Ad oggi non esistono tributi "propri" dell'Unione europea. La loro imposizione solleva questioni tecniche di grande rilevanza e postula una spinta verso l'armonizzazione e il coordinaemnto delle politiche fiscali degli Stati membri. L'istituzione di tributi "comunitari" implicherebbe la nascita di un rapporto giuridico d'imposta tra contribuente e istituzioni comunitarie e dovrebbe avvenire senza innalzare l'attuare pressione fiscale all'interno degli Stati membri.

EU-Taxes - Taxing competences within the legal framework of the European Community, national report for Italy

2008

Exploiting Maximum Entropy method and ASTER data for assessing debris flow and debris slide susceptibility for the Giampilieri catchment (north-easte…

2016

This study aims at evaluating the performance of the Maximum Entropy method in assessing landslide susceptibility, exploiting topographic and multispectral remote sensing predictors. We selected the catchment of the Giampilieri stream, which is located in the north-eastern sector of Sicily (southern Italy), as test site. On 1 October 2009, a storm rainfall triggered in this area hundreds of debris flow/avalanche phenomena causing extensive economical damage and loss of life. Within this area a presence-only-based statistical method was applied to obtain susceptibility models capable of distinguishing future activation sites of debris flow and debris slide, which where the main source of fai…

The Evaluation of the Cultural Industries Impacts on the Local Economies: The Teatro Massimo Foundation

2022

Thanks to its relevant positive effects, the cultural industry, including the Opera Houses, is becoming increasingly important for economic and social well-being. On the other hand, given their cultural relevance and the high costs, these activities require the support of public funds. This evidence generates the need to quantify the economic benefits deriving from its activities to evaluate the opportunity and the return of the public financial support. The study analyses the case of the Fondazione Teatro Massimo di Palermo offering an estimate of the economic, occupational, and fiscal impact on the municipal, provincial, regional, and national territories. The results show how the Opera H…

Long-term outcomes comparison of different types of des in elderly patients from a real-world experience

2009

OBJECTIVE: We sought to evaluate the impact on long-term clinical outcomes of different types of drug-eluting stents (DES) in elderly patients. BACKGROUND: Elderly patients constitute a fast-growing portion of cardiovascular patients, however, they are not adequately represented in clinical trials. Moreover, few data comparing different type of DES in elderly patients are available. METHODS: From a total of 2,330 consecutive patients treated at our institution with DES, we selected 207 elderly patients (≥ 75 years of age) who underwent, from May 2002 to December 2006, sirolimus-eluting stent (SES group, 116 patients [pts], 56%) or paclitaxel-eluting stent (PES group, 91 pts, 43.9%) implanta…

Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.

2007

Cytotoxic chemotherapies are standard of care for patients suffering from advanced non-small cell lung cancer (NSCLC). However, objective responses are only achieved in 20% of cases and long-term survival is rarely observed. Clinically applied anticancer drugs exert at least some of their activities by inducing apoptosis. A critical step in apoptotic signal transduction is the permeabilization of the mitochondrial outer membrane (MOM), which is regulated by the BCL-2 family of proteins. Hence, therapeutic targeting of BCL-2 proteins is a promising approach to increase the drug-sensitivity of cancers. To this end we have assessed the impact of conditional expression of the proapoptotic multi…

Decision-making Tool for Moving from 3-axes to 5-axes CNC Machine-tool

2016

Abstract Nowadays most of the parts within machine-building industry are machines on CNC machine-tools. According to their mechanical and kinematic structure, CNC machine-tools can be divided into 3-axes and 5-axes ones. Each type has its advantages and drawbacks and choosing between them could be a very difficult process. This paper presents a decision support tool for aiding the process of selecting between using and/or buying either a 3-axes CNC milling machine or a 5-axes milling machine, based upon fuzzy logic. The tool was built using the Fuzzy Logic Toolbox and the fuzzy graphical user interface (GUI) within Matlab software package.

Issues on Financing Sources of Environmental Fund In Romania

2017

Abstract Environmental taxation has been developing for decades and it started to gain its importance, especially with the European Union extending. The usage of taxes as a part of environmental policy has been known for some time in Romania and developments in this area continued year by year. The present paper explores the current system of environmental taxes in Romania. It highlights the importance of car pollution tax in financing Environmental Fund and the existence of many tax liabilities irrelevant as financial importance.

Evaluation of multi-hazard map produced using MaxEnt machine learning technique.

2021

Abstract Natural hazards are diverse and uneven in time and space, therefore, understanding its complexity is key to save human lives and conserve natural ecosystems. Reducing the outputs obtained after each modelling analysis is key to present the results for stakeholders, land managers and policymakers. So, the main goal of this survey was to present a method to synthesize three natural hazards in one multi-hazard map and its evaluation for hazard management and land use planning. To test this methodology, we took as study area the Gorganrood Watershed, located in the Golestan Province (Iran). First, an inventory map of three different types of hazards including flood, landslides, and gul…