Search results for "Axia"
showing 10 items of 638 documents
Coaxial Slot Antenna Design for Microwave Hyperthermia using Finite- Difference Time-Domain and Finite Element Method
2011
Hyperthermia also called thermal therapy or thermotherapy is a type of cancer treatment in which body tissue is exposed to high temperatures. Research has shown that high temperatures can damage and kill cancer cells, usually with minimal injury to normal tissues. Otherwise, ablation or high temperature hyperthermia, including lasers and the use of radiofrequency, microwaves, and high-intensity focused ultrasound, are gaining attention as an alternative to standard sur- gical therapies. The electromagnetic microwave irradiation applied to the tumor tissue causes water molecules to vibrate and rotate, resulting in tissue heating and subsequently cell death via thermal-induced protein denatur…
Mutual inductance of thick coils for arbitrary relative orientation and position
2017
An exact solution method has been developed recently which gives the mutual inductance of two thin cylindrical coils in terms of line integrals of a new kind of vector potential, induced by the primary coil, around the two circular edges of the secondary coil. This paper describes the extension of this method to thick coils, by wrapping two radial integrations around these line integrals. Results are presented for two pairs of conventional coils and a combination of a superconducting coil and a Bitter coil. Excellent agreement with existing results for non coaxial coils was obtained. The trade-off between accuracy and computing time is also examined.
The origin of in-plane stresses in axially moving orthotropic continua
2016
In this paper, we address the problem of the origin of in-plane stresses in continuous, two-dimensional high-speed webs. In the case of thin, slender webs, a typical modeling approach is the application of a stationary in-plane model, without considering the effects of the in-plane velocity field. However, for high-speed webs this approach is insufficient, because it neglects the coupling between the total material velocity and the deformation experienced by the material. By using a mixed Lagrange–Euler approach in model derivation, the solid continuum problem can be transformed into a solid continuum flow problem. Mass conservation in the flow problem, and the behaviour of free edges in th…
Über zinn-haltige heterocyclen
1983
Abstract The crystal structure of 2,2,6-trimethyl-1,3-dithia-6-aza-2-stannocane has been determined and refined to R = 0.043. The transannular 1,5-distance Sn ⋯ N = 256.6(6) pm exceeds the respective single bond by 49 pm. A comparison with analogous eight-membered rings exhibits a clear-cut correlation of such differences with angle deformations in the transition tetrahedron to trigonal-bipyramid. The axial distance SnC is 2 pm longer than the equatorial one.
α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice.
2011
The arginine-glycine-aspartate (RGD) motif in fibronectin (FN) represents the major binding site for α5β1 and αvβ3 integrins. Mice lacking a functional RGD motif in FN (FN(RGE/RGE)) or α5 integrin develop identical phenotypes characterized by embryonic lethality and a severely shortened posterior trunk with kinked neural tubes. Here we show that the FN(RGE/RGE) embryos arrest both segmentation and axis elongation. The arrest is evident at about E9.0, corresponding to a stage when gastrulation ceases and the tail bud-derived presomitic mesoderm (PSM) induces α5 integrin expression and assumes axis elongation. At this stage cells of the posterior part of the PSM in wild type embryos are tight…
Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase.
2001
AbstractThe bacterial cytolethal distending toxin (CDT) triggers a G2/M cell cycle arrest in eukaryotic cells by inhibiting the CDC25C phosphatase-dependent CDK1 dephosphorylation and activation. We report that upon CDT treatment CDC25C is fully sequestered in the cytoplasmic compartment, an effect that is reminiscent of DNA damage-dependent checkpoint activation. We show that the checkpoint kinase CHK2, an upstream regulator of CDC25C, is phosphorylated and activated after CDT treatment. In contrast to what is observed with other DNA damaging agents, we demonstrate that the activation of CHK2 can only take place during S-phase. Use of wortmannin and caffeine suggests that this effect is no…
The Friedreich's Ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals
2010
DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth. Recent evidence suggests that specific DNA-repair enzymes contain ISCs (iron–sulfur clusters). The nuclearencoded protein frataxin is essential for the mitochondrial biosynthesis of ISCs. Frataxin deficiency causes a neurodegenerative disorder named Friedreich's ataxia in humans. Various types of cancer occurring at young age are associated with this disease, and hence with frataxin deficiency. Mice carrying a hepatocyte-specific disruption of the frataxin gene develop multiple liver tumours for unresolved reasons. In the present study, we show that frata…
Agreement of predicted intraocular lens power using swept-source optical coherence tomography and partial coherence interferometry
2021
PURPOSE To analyze the agreement of the predicted intraocular lens (IOL) power obtained with ANTERION, IOLMaster 700 and Pentacam AXL biometers. METHODS We calculated the monofocal and trifocal IOL power using the SRK/T, Haigis, Barrett Universal II and Hoffer Q formulas for 106 eyes. IOL power agreement between devices was evaluated using the Bland-Altman method. RESULTS We found significant differences between biometers comparisons (p 0.05), with the same outcomes for medium- and long-eyes. No significant differences were found using the SRK/T, Haigis, or Hoffer Q formulas for short-eyes (p > 0.1). However, Barrett Universal II formula produced significant differences (p < 0.05) and thes…
Graphic representation of data resulting from measurement comparison trials in cataract and refractive surgery.
2003
* BACKGROUND AND OBJECTIVES: The evaluation of new diagnostic measurement devices allows intraindividual comparison with an established standard method. However, reports in journal articles often omit the adequate incorporation of the intraindividual design into the graphic representation. * PATIENTS AND METHODS: This article illustrates the drawbacks and the possible erroneous conclusions caused by this misleading practice in terms of recent method comparison data resulting from axial length measurement in 220 consecutive patients by both applanation ultrasound and partial coherence interferometry. * RESULTS: Graphic representation of such method comparison data should be based on boxplots…
Proximal and distal. Rethinking linguistic form and use for clinical purposes.
2010
With clinical purposes in mind, a review of the proximal/distal opposition is carried out in order to define a universal parameter of variability in semiotic procedures. By taking into consideration different-although notionally inter-related-senses of the proximal/distal opposition, a cluster of semiotic properties is proposed, which initially permits one to characterize dimensions of variability in the form and use of gestures. The subsequent and central aim of this paper is, however, to demonstrate that the same, or homologous, properties can also serve to characterize variability in the use of language, by assuming a basic connection between gesturing and linguistic behaviour. The main …