Search results for "Azide"

ChemInform Abstract: Polycondensed Nitrogen Heterocycles. Part 25. Aminopyrrolo(1,2-f) phenanthridines by Decomposition of 2-(3-Azidophenyl)-1-arylpy…

2010

Acid catalyzed decomposition of the azido derivatives 4a-c gave rise to amino-hydroxy-phenylpyrroles of type 7 and 8 upon hydrolysis of the intermediate aryl nitrenium ions, together with the hydrogen abstraction compounds of type 3. The aminopyrrolo[1,2-f]phenanthridines 10, 11, and 12 were obtained by treatment with TFMSA of the azide 4d in which the ring being attacked was made more nucleophilic by the introduction of the methoxy group.

ChemInform Abstract: Pyrazolo[3,4-d]pyrimidine Derivatives as COX-2 Selective Inhibitors: Synthesis and Molecular Modelling Studies.

2009

The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties. Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters. Compounds 8a, b, 10a-d, and 11a, b revealed a superior inhibitory profile against COX-2, when compared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.

Pyrazolo[3,4‐d]pyrimidine Derivatives as COX‐2 Selective Inhibitors: Synthesis and Molecular Modelling Studies

2009

The pyrazolo[3,4-d]pyrimidine system shows a multitude of interesting pharmacological properties. Owing to the potential anti-inflammatory activity of 5-benzamido-pyrazolo[3,4-d]pyrimidin-4-one derivatives and considering the easy synthesis of this class of compounds, a set of new 5-benzamido-1H-pyrazolo[3,4-d]pyrimidin-4-ones has been prepared in 42-80% yields by reacting 5-aminopyrazole-4(N-benzoyl)carbohydrazide derivatives and the opportune triethylorthoesters. Compounds 8a, b, 10a-d, and 11a, b revealed a superior inhibitory profile against COX-2, when compared to that of reference standards NS398 and indomethacin. Molecular modelling studies confirmed the obtained biological results.

Potentiometric studies on azido complexes of the aquodimethyltin(IV) cation in aqueous solution

1974

Summary Mono and polynuclear azide complexes of the aquodimethyltin(IV) cation have been studied in solution at [ClO 4 − ]=3.00 M , by e.m.f. measurements of [H + ], using the competitive reaction method. Throughout the entire range of data, 2.5≤−log[N 3 − ] free ≤4.9, the results are interpreted by assuming that the complexes {[(CH 3 ) 2 Sn] 3 [N 3 ] 3 } 3+ and [(CH 3 ) 2 Sn(N 3 ) 4 ] 2− predominate; the cumulative equilibrium constants for their formation are log β 33 =12.98±0.03 and log β 14 =2.45±0.02.

ChemInform Abstract: Synthesis of a Tetraazido-Substituted 2-Tetrazene from 1,5- Cyclooctadiene and Iodine Azide.

2010

In contrast to the addition of iodine azide to cyclooctene (1) or 1,3-cyclooctadiene (5), its reaction with 1,5-cyclooctadiene (12) leads mainly to the surprisingly stable tetraazido-substituted 2-tetrazene 14 The structure of this was established by 15N-NMR studies and an X-ray structural analysis. Treatment of 14 with hydrochloric acid yields the diazido-substituted 9-azabicyclo[3.3.1]nonane 20.

Strukturchemie der Azide

2005

Triazolopyridines. Part 9. The synthesis of7-amino(1,2,3)triazolo(1,5-a)pyridines

1989

Abstract Regiospecific lithiation of (1,2,3) triazolo(1,5-a)pyridines (1) and (4) with subsequent reaction with styryl azide gave small yields of the 7-aminotriazolopyridines (6) and (7). A longer larger scale synthesis of compounds (6) and (7) is described giving overall yields of 17 and 25%, starting from 2-amino-6-methyl (9) or 2-amino-6-ethyl pyridine (19).

Playing with different metalloligands [NiL] and Hg to [NiL] ratios to tune the nuclearity of Ni(II)–Hg(II) complexes: Formation of di-, tri-, hexa- a…

2015

Abstract Five new hetero-metallic nickel(II)–mercury(II) complexes, [(NiL1)HgCl2] (1), [(NiL1)2HgCl2] (3), [(NiL1)2Hg(N3)2] (4), [{(NiL2)2Hg(N3)(μ1,1-N3)}2] (5) and [{(NiL2)2Hg(N3)(μ1,1-N3)HgCl2}2{Hg(N3)(μ1,1-N3)}] (6) have been synthesized by reacting metalloligands [NiL1] or [NiL2] (where H2L1 is N,N′-bis(salicylidene)-1,2-ethylenediamine and H2L2 is N,N′-bis(salicylidene)-1,3-propanediamine) with HgX2 (X− = Cl− or N3−) at different molar ratios. All five complexes have been characterised by X-ray single-crystal structural, elemental and spectroscopic analyses. In complex 1, the Hg(II) ion is coordinated to two phenoxido oxygen atoms of one [NiL1] moiety and two terminal chloride ions to …

Polynuclear copper(II) complexes with μ2-1,1-azide bridges. Structural and magnetic properties

1996

Abstract Two novel, weakly antiferromagnetically coupled, tetranuclear copper(II) complexes [Cu4(PAP)2(μ2-1,1-N3)2(μ2-1,3-N3)2(μ2-CH3OH)2(N3)4 (1) (PAP = 1,4-bis-(2′-pyridylamino)phthalazine) and [Cu4(PAP3Me)2 (μ2-1,1-N3)2(μ2-1,3-N3)2(H2O)2(NO2)2]- (NO3)2 (2) (PAP3Me = 1,4-bis-(3′-methyl-2′-pyridyl)aminophthalazine) contain a unique structural with two μ2-1,1-azide intramolecular bridges, and two μ2-1,3-azide intermolecular bridges linking pairs of copper(II) centers. Four terminal azide groups complete the five-coordinate structures in 1, while two terminal waters and two nitrates complete the coordination spheres in 2. The dinuclear complexes [Cu2(PPD)(μ2-1,1-N3)(N3)2(CF3SO3)]CH3OH) (3) a…

Magneto-structural correlations and DFT calculations in two rare tetranuclear copper(II)-clusters with doubly phenoxo and end-on azido bridges: Synth…

2010

International audience; By slightly changing the synthetic conditions, we have prepared two closely related linear tetranuclear CuII complexes with the symmetrical ONNO donor tetradentate Schiff-base ligand [H2L = (OH)C6H4(CH3)Cdouble bond; length as m-dashN(CH2)3Ndouble bond; length as m-dashC(CH3)C6H4(OH)] and with azide ions. These two distinctly coloured crystalline products were characterized by elemental analysis, IR and UV–Vis spectroscopy, CV, EPR spectra and variable temperature magnetic measurements. Single crystal X-ray diffraction studies of the green [Cu4(μ-L)2(μ1,1-N3)2(N3)2] (1) and the red [Cu4(μ-L)2(μ1,1-N3)2(N3)2(H2O)2] (2) crystals show that the coordination environment o…