Search results for "Azine"
showing 10 items of 1589 documents
A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents.
1968
Effect of donor substituents on thermally activated delayed fluorescence of diphenylsulfone derivatives
2019
This research was funded by the European Social Fund according to the activity ‘Improvement of researchers’ qualification by implementing world-class R&D projects’ of Measure No. 09.3.3-LMT-K-712. DG acknowledges to the ERDF PostDoc project No. 1.1.1.2/VIAA/1/16/177;
3-CHLOROETHYL-PYRROLO[2,1-D][1,2,3,5]TETRAZINES: SYNTHESIS AND ANTITUMOR ACTIVITY
2011
Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus
2014
While the expression of glycine receptors in the immature hippocampus has been shown, no information about the role of glycine receptors in controlling the excitability in the immature CNS is available. Therefore, we examined the effect of glycinergic agonists and antagonists in the CA3 region of an intact corticohippocampal preparation of the immature (postnatal days 4-7) rat using field potential recordings. Bath application of 100 μM taurine or 10 μM glycine enhanced the occurrence of recurrent epileptiform activity induced by 20 μM 4-aminopyridine in low Mg(2+) solution. This proconvulsive effect was prevented by 3 μM strychnine or after incubation with the loop diuretic bumetanide (10 …
Synthesis of new fluorinated Tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation.
2008
In previous studies, our group has shown that the use of fluorinated alcohols such as trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation from 1,3-diketone with methylhydrazine. We have now applied this synthetic method to the preparation of new fluorinated pyrazoles, which have then been used as synthetic intermediates in the preparation of fluorinated analogs of Tebufenpyrad, a commercial acaricide. These compounds display a strong acaricidal activity that is either comparable to or better than that of the commercial compound.
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives
2008
Abstract A series of easily affordable phenothiazine derivatives bearing a rigid but-2-ynyl amino side chain were synthesized and tested to evaluate the MDR reverting activity and full antitumor profile. Some compounds endowed with remarkable MDR reverting effect were identified, and the most active one ( 6c ) was shown to increase doxorubicin retention in multidrug resistant cells, suggesting a direct interaction with P-glycoprotein. Furthermore, a broad range of cellular activities were observed for different compounds. In particular, the ability of some derivatives to induce antiproliferative effects on resistant cell lines and to interfere with the G 1 phase of the cell cycle, a phase u…
ChemInform Abstract: ortho-Functionalized Aryltetrazines by Direct Palladium-Catalyzed C-H Halogenation: Application to Fast Electrophilic Fluorinati…
2016
A general catalyzed direct C-H functionalization of s-tetrazines is reported. Under mild reaction conditions, N-directed ortho-C-H activation of tetrazines allows the introduction of various functional groups, thus forming carbon-heteroatom bonds: C-X (X=I, Br, Cl) and C-O. Based on this methodology, we developed electrophilic mono- and poly-ortho-fluorination of tetrazines. Microwave irradiation was optimized to afford fluorinated s-aryltetrazines, with satisfactory selectivity, within only ten minutes. This work provides an efficient and practical entry for further accessing highly substituted tetrazine derivatives (iodo, bromo, chloro, fluoro, and acetate precursors). It gives access to …
"Would I run the pub if I won the Lottery? No." : a study on how ordinary people are constructed and described in British supplement magazines
2012
Tavallisten ihmisten rooli ja näkyvyys mediassa on lisääntynyt teknologiavälitteisen ja sosiaalisen median myötä nyky-yhteiskunnassa. Tavallisten ihmisten rooli on muuttunut sosiaalisessa mediassa yleisöstä esiintyjäksi, kun taas perinteisessä lehtijournalismissa he edelleen kuuluvat vähemmistöön. Tämän tutkielman tavoitteena on selvittää, minkälaisia human interest -tarinoita tavallisista ihmisistä kerrotaan ja minkä takia ne ovat valittu julkaistavaksi. Lisäksi tavoitteena on tutkia hyödyntäen Bellin (1991) uutisteksteille suunnattua rakennemallia, miten ja mistä osista tarinat rakentuvat narratiivisesti. Samalla kartoitetaan, mitä tyypillisiä aihealueita tavallisten ihmisten tarinoissa t…
Traducción y recepción: Rosalía de Castro en Italia
2020
El panorama de la recepción italiana contemporánea de los poetas españoles del siglo XIX, a través de las traducciones, no resulta especialmente satisfactorio, puesto que hay que esperar el siglo siguiente para encontrar los primeros estudios monográficos y ediciones de textos en traducción, aunque en forma antológica. Ello, no obstante, así como en el resto de Europa, el corpus de las publicaciones periódicas de las revistas ofrece un canal editorial muy proficuo para la recepción de textos literarios extranjeros. Este trabajo se centra en la presencia de la obra de Rosalía de Castro en la prensa italiana contemporánea. Al mismo tiempo, se ha intentado completar el estudio de la recepción …
Ferromagnetic Coupling Through the End-to-End Thiocyanate Bridge in Cobalt(II) and Nickel(II) Chains
2015
The preparation, spectroscopic characterization, and X-ray crystal structure of two novel one-dimensional compounds of formula [MII(tppz)(NCS)(μ-1,3-NCS)]n [tppz = 2,3,5,6-tetrakis(2-pyridyl)pyrazine and M = Co(1) and Ni (2)] are reported. 1 and 2 are isomorphous compounds, and they crystallize in the P21/n space group. Their structures are made up of zigzag chains of cobalt(II) (1) and nickel(II) ions (2) bridged by single end-to-end thiocyanate groups with a tridentate tppz molecule and a terminally bound thiocyanate-N ligand achieving distorted MN5S octahedral surroundings around each metal center. The main source of the distortion of the ideal octahedron is due to the geometrical constr…