Search results for "Azine"
showing 10 items of 1589 documents
Immobilization of Hexacyanoferrate (III) for a Flow Injection-Spectrophotometric Determination of Promazine
1993
Abstract An automated flow injection method for the determination of promazine is described. The method is based on the oxidation of promazine by hexacyanoferrate (III) and spectrophotometric monitorization of oxidized drug. The chemical and FIA variables were optimized. The calibration graph was linear over the concentration range 2,5–25 ppm of promazine hydrochloride. Some interfering substances were also investigated. The method was applied for the determination of promazine in pharmaceutical formulations.
Strukturuntersuchungen von polyamiden aus cyclischen dicarbonsäuren und piperazin durch direkten abbau im massenspektrometer
1977
Polyamide aus 1,2-Cyclobutan-, 1,2-Cyclopentan- und 1,2-Cyclohexandicarbonsaure und Piperazin wurden direkt in der Ionenquelle eines Massenspektrometers pyrolysiert. Die hohe Empfindlichkeit der massenspektrometrischen Methode erlaubt, bei Abbauraten von ca. 1%/min zu pyrolysieren und dadurch selektive thermische Abbaumechanismen neben den Fragmentierungsreaktionen nachzuweisen. Durch thermischen Abbau werden dabei Oligomere mit Piperazinendgruppen sowie gesattigte und ungesattigte Cyclobutan-, -pentan- und -hexanendgruppen gebildet. Polyamides of 1,2-cyclobutane-, 1,2-cyclopentane- and 1,2-cyclohexane-dicarboxylic acid and piperazine were pyrolyzed directly in the ion source of a mass spec…
Electrochemical formation of N,N′-diarylhydrazines by dehydrogenative N–N homocoupling reaction
2020
Hydrazines represent a class of compounds of high interest due to their applicability as versatile starting materials in many important transformations. Herein, we report a synthetic approach to hydrazine derivatives using commercially available anilines and an anodic dehydrogenative N-N coupling reaction as the key step.
Synthesis and X-ray Crystal Structure Analysis of Substituted 1,2,4-Triazolo [4’,3’:2,3]pyridazino[4,5-b]indole and Its Precursor
2023
The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was obtained by recrystallization from methanol. The suggested structures of compounds 1 and 3 based on the spectral characterizations were confirmed by X-ray single crystal diffraction analysis. Compound 3 crystallized in the triclinic crystal system and P-1 space group with a = 5.9308(2) Å, b = 10.9695(3) Å, c = 14.7966(4) Å, α = 100.5010(10)°, β = 98.6180(10)°, and γ = 103.8180(10)°. On the other hand, the crystal system of 1 is monoclinic, whe…
HSP10,HSP70 AND HSP90 IMMUNOHISTOCHEMICAL LEVELS CHANGE IN ULCERATIVE COLITIS AFTER THERAPY
2011
Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones:…
Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: Investigation by flow cyt…
2007
Background: The 7-ketocholesterol (7KC)-induced cell death has some characteristics of apoptosis and is associated with polar lipid accumulation. So, we investigated the effects of the broad-spectrum caspase inhibitor z-VAD-fmk and of the caspase-2 inhibitor z-VDVAD-fmk on lipid profile evaluated by staining with Nile Red (NR). Methods: The 7KC-treated human monocytic U937 cells were cultured in the absence or in the presence of the caspase inhibitors z-VAD-fmk or z-VDVAD-fmk. When staining with NR is performed, neutral and polar lipids have yellow and orange/red emission, respectively, and fluorescence was then analyzed by flow cytometry (FCM) and by confocal laser scanning microscopy (CLS…
La voz de una autoridad heterodoxa sobre el amor en el primer franquismo. Los consultorios sentimentales de Amparo Rivelles
2021
Entre 1948 y 1952, el semanario cinematográfico Primer plano publicó un consultorio sentimental firmado por la actriz Amparo Rivelles. La estrella española más popular del momento se convertía así en consejera sobre la moral, el noviazgo y los usos amorosos entre los jóvenes; una cuestión que el Régimen consideraba como una pieza fundamental en la regulación de las relaciones de género. Se trata de un consultorio singular, alejado de la gravedad, el dramatismo y la grandilocuencia de otros, surgidos en diversos medios periodísticos a raíz de la buena acogida de público que estas secciones gozaron durante aquellos años. El presente artículo analiza las implicaciones de unos textos en los que…
How to Become an Author: The Poet Isa Asp and Her Childhood Fascination with Writing for Magazines
2021
In this article the author explores the early development of the identity as a writer of a Finnish-speaking poet Lovisa (or Isa) Asp (1853–1872). She wrote her lyrics in the Finnish language in the 1870s, and she is regarded as the first 19th-century female Finnish poet (whose works were published in Finnish). She began writing poetry (initially in Swedish) as a teenager and started her literary career as a contributor to children’s magazines. Asp began her studies at the Teacher Training College in Jyväskylä in autumn 1871 with the aim of working as an elementary school teacher, but she also dreamt of becoming an established writer someday. Unfortunately, her early death meant that most of…
A new multi analytical approach for the identification of synthetic and natural dyes mixtures. The case of orcein-mauveine mixture in a historical dr…
2017
In this paper, the application of a multi-analytical approach for the characterisation of synthetic and natural dyes in a historical textile is presented. The work is focused on a historical dress of a Sicilian noblewoman, dating from about 1865–1870. Firstly, SERS on fibre was performed, in order to individuate the classes of dyes employed. The SERS spectra suggested the presence of two main dyes: mauveine and orcein. In order to confirm these preliminary results, two different extraction protocols were applied. The extracts obtained were analysed by ESI-MS, MALDI-ToF and UHPCL-MS analyses, confirming the SERS results. In particular, the application of the ammonia mild extraction technique…
Solvent Exchange in Thermally Stable Resorcinarene Nanotubes
2006
The assembly of C-methyl resorcinarene into a tubular supramolecular solid-state structure, its thermal stability, and its hosting properties are reported. Careful control of the crystallisation conditions of C-methyl resorcinarene and 1,4-dimethyl-1,4-diazoniabicyclo[2.2.2]octane (1,4-dimethyl DABCO) dibromide leads to a formation of two crystallographically different, but structurally very similar, solid-state nanotube structures. These structures undergo a remarkable variety of supramolecular interactions, which lead to the formation of 0.5 nm diameter nonpolar tubes through the crystal lattice. The formation of these tubes is templated by suitably sized small alcohols, namely, n-propano…