Search results for "Azole"

showing 10 items of 2392 documents

Grazoprevir/elbasvir for the immediate treatment of recently acquired HCV genotype 1 or 4 infection in MSM.

2020

Abstract Background In Europe, increases in HCV infection have been observed over the last two decades in MSM, making them a key population for recently acquired HCV. Alternative combinations of direct-acting antiviral agents against early HCV infection need to be assessed. Patients and methods In this pilot trial, MSM with recently acquired genotype 1 or 4 HCV infection were prospectively included and received 8 weeks of oral grazoprevir 100 mg and elbasvir 50 mg in a fixed-dose combination administered once daily. The primary endpoint was sustained virological response evaluated 12 weeks after the end of treatment (EOT) (SVR12). Secondary endpoints were the virological characterization of…

hepatitis C virusCyclopropanesMaleadverse eventmen who have sex with menHepacivirusmedicine.disease_causeSexual and Gender Minoritiesblood HIV RNA0302 clinical medicine[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesfollow-upClinical endpointMedicinePharmacology (medical)infections030212 general & internal medicinehepatitis ceducation.field_of_studySulfonamideshepatitis c rnaImidazolesvirus diseasesHepatitis Cvirologyhepatitis C virus genotype 13. Good healthEuropeInfectious DiseasesGrazoprevirRNA Viral030211 gastroenterology & hepatologyDrug Therapy CombinationMicrobiology (medical)medicine.medical_specialtyElbasvirGenotypeHepatitis C virusPopulationelbasvirAntiviral Agentsreinfection03 medical and health sciencesInternal medicineQuinoxalinesHumansHomosexuality MaleAdverse effecteducationplasmasuicideBenzofuransPharmacologybusiness.industrySurrogate endpointHIVgrazoprevirHepatitis C Chronicmedicine.diseaseAmidessurrogate endpoints[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/PharmacologyQuality of LifeCarbamatesbusinessThe Journal of antimicrobial chemotherapy
researchProduct

Rearrangements of 1,2,4-Oxadiazole: “One Ring to Rule Them All”

2017

[Figure not available: see fulltext.] 1,2,4-Oxadiazoles are heterocycles characterized by low aromaticity and the presence of a weak O–N bond and are widely studied due to their tendency to rearrange into more stable heterocyclic compounds. This review covers literature from the last fifteen years, highlighting the general features of 1,2,4-oxadiazoles and their applications. Regarding the reactivity, the development of classical reactions (thermal and photochemical rearrangements) is presented in terms of synthetic utility and mechanistic insight. Among the relevant rearrangement reactions, the Boulton–Katritzky Rearrangement (BKR), Migration – Nucleophilic Attack – Cyclization (MN…

heterocyclic rearrangementphotochemistry010405 organic chemistryOrganic Chemistry124-oxadiazoleOxadiazoleBoulton–Katritzky rearrangementAromaticitySettore CHIM/06 - Chimica Organica010402 general chemistryRing (chemistry)01 natural sciences0104 chemical scienceschemistry.chemical_compoundNucleophilechemistryComputational chemistryANRORCReactivity (chemistry)Chemistry of Heterocyclic Compounds
researchProduct

CCDC 214223: Experimental Crystal Structure Determination

2003

Related Article: J.Kusz, H.Spiering, P.Gutlich|2001|J.Appl.Crystallogr.|34|229|doi:10.1107/S0021889801000462

hexakis(1-Methyltetrazole)-iron(ii) bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 214224: Experimental Crystal Structure Determination

2003

Related Article: J.Kusz, H.Spiering, P.Gutlich|2001|J.Appl.Crystallogr.|34|229|doi:10.1107/S0021889801000462

hexakis(1-Methyltetrazole)-iron(ii) bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 214222: Experimental Crystal Structure Determination

2003

Related Article: J.Kusz, H.Spiering, P.Gutlich|2001|J.Appl.Crystallogr.|34|229|doi:10.1107/S0021889801000462

hexakis(1-Methyltetrazole)-iron(ii) bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 251390: Experimental Crystal Structure Determination

2004

Related Article: J.Kusz, H.Spiering, P.Gutlich|2004|J.Appl.Crystallogr.|37|589|doi:10.1107/S0021889804011720

hexakis(1-Propyltetrazole-N^4^)-zinc(ii) bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 251393: Experimental Crystal Structure Determination

2004

Related Article: J.Kusz, H.Spiering, P.Gutlich|2004|J.Appl.Crystallogr.|37|589|doi:10.1107/S0021889804011720

hexakis(1-Propyltetrazole-N^4^)-zinc(ii) bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 251394: Experimental Crystal Structure Determination

2004

Related Article: J.Kusz, H.Spiering, P.Gutlich|2004|J.Appl.Crystallogr.|37|589|doi:10.1107/S0021889804011720

hexakis(1-Propyltetrazole-N^4^)-zinc(ii) bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 866767: Experimental Crystal Structure Determination

2012

Related Article: J.Kusz, M.Zubko, R.B.Neder, P.Gutlich|2012|Acta Crystallogr.,Sect.B:Struct.Sci.|68|40|doi:10.1107/S0108768111053298

hexakis(1-n-Propyl-1H-tetrazole)-iron bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 866765: Experimental Crystal Structure Determination

2012

Related Article: J.Kusz, M.Zubko, R.B.Neder, P.Gutlich|2012|Acta Crystallogr.,Sect.B:Struct.Sci.|68|40|doi:10.1107/S0108768111053298

hexakis(1-n-Propyl-1H-tetrazole)-iron bis(tetrafluoroborate)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
researchProduct