Search results for "B.8"
showing 10 items of 36 documents
Temperature and pH define the realised niche space of arbuscular mycorrhizal fungi
2021
Made available in DSpace on 2021-06-25T11:52:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-04 European Regional Development Fund (Centre of Excellence EcolChange) University of Tartu (Estonian Research Council ) Moscow State University Natural Sciences and Engineering Research Council of Canada Discovery Grant Russian Science Foundation Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Swedish Research Council (Vetenskapsradet) The arbuscular mycorrhizal (AM) fungi are a globally distributed group of soil organisms that play critical roles in ecosystem function. However, the ecological niches of individual AM fungal taxa are poorly understood. We collected > 300 s…
On-demand autophagic network adaptations upon limited lipid availability
2020
The de novo synthesis of autophagic vesicles is strongly dependent on sufficient lipid supply. Recently, the RAB GTPase RAB18 was shown to affect autophagy by mediating fatty acid release from lipid droplets, which are lipid sources for autophagosome formation. The stable loss of RAB18 interfered with fatty acid release from the lipid reservoirs and provoked autophagy network adaptations aiming to maintain autophagic activity under lipid limiting conditions.
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidati…
2019
Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintain proteostasis. Here, we report that hippocampal cells selected for full adaptation and resistance to oxidative stress induced by hydrogen peroxide (oxidative stress-resistant cells, OxSR cells) showed a massive increase in the expression of components of the cellular autophagic-lysosomal network and a significantly higher overall autophagic activity. A comparative expression analysis revealed that distinct key regulators of autophagy are upregu…
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins.
2017
Among nucleic acid–based delivery platforms, self-amplifying RNA (saRNA) vectors are of increasing interest for applications such as transient expression of recombinant proteins and vaccination. saRNA is safe and, due to its capability to amplify intracellularly, high protein levels can be produced from even minute amounts of transfected templates. However, it is an obstacle to full exploitation of this platform that saRNA induces a strong innate host immune response. In transfected cells, pattern recognition receptors sense double-stranded RNA intermediates and via activation of protein kinase R (PKR) and interferon signaling initiate host defense measures including a translational shutdow…
Prognostic Role of Blood Eosinophil Count in Patients with Sorafenib-Treated Hepatocellular Carcinoma.
2020
Background: Inflammation is a long-established hallmark of liver fibrosis and carcinogenesis. Eosinophils are emerging as crucial components of the inflammatory process influencing cancer development. The role of blood eosinophils in patients with hepatocellular carcinoma receiving systemic treatment is an unexplored field. Objective: The objective of this study was to analyse the prognostic role of the baseline eosinophil count in patients with sorafenib-treated hepatocellular carcinoma. Patients and Methods: A training cohort of 92 patients with advanced- or intermediate-stage sorafenib-treated hepatocellular carcinoma and two validation cohorts of 65 and 180 patients were analysed. Overa…
The RAB GTPase RAB18 modulates macroautophagy and proteostasis
2017
Macroautophagy is a conserved degradative pathway and its deterioration is linked to disturbances in cellular proteostasis and multiple diseases. Here, we show that the RAB GTPase RAB18 modulates autophagy in primary human fibroblasts. The knockdown of RAB18 results in a decreased autophagic activity, while its overexpression enhances the degradative pathway. Importantly, this function of RAB18 is dependent on RAB3GAP1 and RAB3GAP2, which might act as RAB GEFs and stimulate the activity of the RAB GTPase. Moreover, the knockdown of RAB18 deteriorates proteostasis and results in the intracellular accumulation of ubiquitinated degradation-prone proteins. Thus, the RAB GTPase RAB18 is a positi…
Compound conditionals as random quantities and Boolean algebras
2022
Conditionals play a key role in different areas of logic and probabilistic reasoning, and they have been studied and formalised from different angles. In this paper we focus on the de Finetti's notion of conditional as a three-valued object, with betting-based semantics, and its related approach as random quantity as mainly developed by two of the authors. Compound conditionals have been studied in the literature, but not in full generality. In this paper we provide a natural procedure to explicitly attach conditional random quantities to arbitrary compound conditionals that also allows us to compute their previsions. By studying the properties of these random quantities, we show that, in f…
Three solutions for a two-point boundary value problem with the prescribed mean curvature equation
2015
The existence of at least three classical solutions for a parametric ordinary Dirichlet problem involving the mean curvature operator are established. In particular, a variational approach is proposed and the main results are obtained simply requiring the sublinearity at zero of the considered nonlinearity.
Critical points in open sublevels and multiple solutions for parameter-depending quasilinear elliptic equations
2014
We investigate the existence of multiple nontrivial solutions of a quasilinear elliptic Dirichlet problem depending on a parameter $\lambda>0$ of the form $$ -\Delta_pu=\lambda f(u)\quad\mbox{in }\ \Omega,\quad u=0\quad\mbox{on }\ \partial\Omega, $$ where $\Omega\subset \mathbb{R}^N$ is a bounded domain, $\Delta_p$, $1 < p < +\infty$, is the $p$-Laplacian, and $f: \mathbb{R}\to \mathbb{R}$ is a continuous function satisfying a subcritical growth condition. More precisely, we establish a variational approach that when combined with differential inequality techniques, allows us to explicitly describe intervals for the parameter $\lambda$ for which the problem under consideration admits nontri…
CCDC 749971: Experimental Crystal Structure Determination
2010
Related Article: Y.Rousselin, N.Sok, F.Boschetti, R.Guilard, F.Denat|2010|Eur.J.Org.Chem.|2010|1688|doi:10.1002/ejoc.200901183