Search results for "B1"

Human parvovirus B19 infection and antiphospholipid-syndrome: the two sides of one medal?

2005

Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and func…

2016

ABSTRACT Mutations in Drosophila Swiss cheese (SWS) or its vertebrate orthologue neuropathy target esterase (NTE), respectively, cause progressive neuronal degeneration in Drosophila and mice and a complex syndrome in humans that includes mental retardation, spastic paraplegia and blindness. SWS and NTE are widely expressed in neurons but can also be found in glia; however, their function in glia has, until now, remained unknown. We have used a knockdown approach to specifically address SWS function in glia and to probe for resulting neuronal dysfunctions. This revealed that loss of SWS in pseudocartridge glia causes the formation of multi-layered glial whorls in the lamina cortex, the firs…

Pensamiento dominante, educación y medios de comunicación

2018

Comunicar es algo más que transmitir información. El desarrollo de la tecnología e internet han evolucionado el acto de comunicar en el mundo y se han creado nuevos espacios de comunicación. Los medios de comunicación suelen estar al servicio de un determinado poder, que puede ser público o privado. Sin embargo en este artículo se pone el acento en los intereses que tienen determinados poderes del ámbito privado y el uso que hacen de los medios de comunicación para defender y promover dichos intereses. No obstante, ese poder también puede dar lugar a formas de resistencias que sirvan para subvertir el orden establecido. Los medios de comunicación sirven como altavoces del pensamiento único …

Studies on sedum taxa found in Sicily (Italy) for mediterranean extensive green roofs

2018

One type of green roof whose function is ecological and environmental rather than aesthetic is the extensive green roof. Many studies have shown that Sedum performs very well compared to other hardy species in substrates of less than 10 cm. It seems that Sedum species are able to survive in very thin substrates; they tolerate extreme temperatures and sudden variations in temperatures, high levels of solar radiation, strong winds, poor substrate fertility and extreme drought. In particular, this paper looks at the potential of a number of species from the Sicilian taxa of the genus Sedum (Crassulaceae), which are considered to be those xerophytes most suited for use in extensive green roof s…

Conservation tillage in a semiarid Mediterranean environment: results of 20 years of research

2014

Conservation tillage techniques are becoming increasingly popular worldwide as they have the potential to generate environmental, agronomic, and economic benefits. In Mediterranean areas, studies performed on the effects of conservation tillage [in comparison with the conventional tillage technique (CT)] on grain yield of cereal crops have reported contradictory results as well as considerable year-to-year variation, demonstrating how the impact of different soil tillage techniques on crop productivity is strongly site-specific. The present paper summarises the main results from a set of experiments carried out in Sicily during the last 20 years in which we compared no tillage (NT) to CT in…

From the Ultimate God to the Virtual God: Post-Ontotheological Perspectives on the Divine in Heidegger, Badiou, and Meillassoux

2014

The Heideggerian account of the ontotheological constitution of Western metaphysics has been extremely influential for contemporary philosophy of religion and for philosophical perspectives on theology and the divine. This paper introduces and contrasts two central strategies for approaching the question of the divine in a non- or post-ontotheological manner. The first and more established approach is that of post-Heideggerian hermeneutics and deconstruction, inspired by Heidegger’s suggestion of a “theology without the word ‘being’” and by his later notions of an “ultimate god” and of “divinities” as one of the four axes of the fourfold (Geviert). Here, the divine is no longer articulated …

Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network

2021

Climate change has been associated with a higher incidence of combined adverse environmental conditions that can promote a significant decrease in crop productivity. However, knowledge on how a combination of stresses might affect plant development is still scarce. MicroRNAs (miRNAs) have been proposed as potential targets for improving crop productivity. Here, we have combined deep-sequencing, computational characterization of responsive miRNAs and validation of their regulatory role in a comprehensive analysis of response of melon to several combinations of four stresses (cold, salinity, short day, and infection with a fungus). Twenty-two miRNA families responding to double and/or triple …

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

2016

Malignant Mesothelioma is a highly aggressive cancer, which is difficult to diagnose and treat. Here we describe the molecular, cellular and morphological characterization of a syngeneic system consisting of murine AB1, AB12 and AB22 mesothelioma cells injected in immunocompetent BALB/c mice, which allows the study of the interplay of tumor cells with the immune system. Murine mesothelioma cells, like human ones, respond to exogenous High Mobility Group Box 1 protein, a Damage-Associated Molecular Pattern that acts as a chemoattractant for leukocytes and as a proinflammatory mediator. The tumors derived from AB cells are morphologically and histologically similar to human MM tumors, and res…

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis.

2014

Background Acute pancreatitis (AP) is a common clinical problem whose incidence has been progressively increasing in recent years. Onset of the disease is trigged by intra-acinar cell activation of digestive enzyme zymogens that induce autodigestion, release of pro-inflammatory cytokines and acinar cell injury. T-cell protein tyrosine phosphatase (TCPTP) is implicated in inflammatory signaling but its significance in AP remains unclear. Results In this study we assessed the role of pancreatic TCPTP in cerulein-induced AP. TCPTP expression was increased at the protein and messenger RNA levels in the early phase of AP in mice and rats. To directly determine whether TCPTP may have a causal rol…

Early embryo achievement through isolated microspore culture in citrus clementina hort. Ex tan., cvs. 'Monreal Rosso' and 'nules'

2015

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