Search results for "B1"

Clinical manifestations of the anti-IgLON5 disease

2017

Objective:To report the presentation, main syndromes, human leukocyte antigen (HLA) association, and immunoglobulin G (IgG) subclass in the anti-IgLON5 disease: a disorder with parasomnias, sleep apnea, and IgLON5 antibodies.Methods:This was a retrospective clinical analysis of 22 patients. The IgG subclass was determined using reported techniques.Results:Patients' median age was 64 years (range 46–83). Symptoms that led to initial consultation included sleep problems (8 patients; 36%), gait abnormalities (8; 36%), bulbar dysfunction (3; 14%), chorea (2; 9%), and cognitive decline (1; 5%). By the time of diagnosis of the disorder, 4 syndromes were identified: (1) a sleep disorder with paras…

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

2013

In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…

Freedom’s Right. The Social Foundations of Democratic Life

2015

The Problem of the First Belief: Group Agents and Responsibility

2020

Abstract Attributing moral responsibility to an agent requires that the agent is a capable member of a moral community. Capable members of a moral community are often thought of as moral reasoners (or moral persons) and, thus, to attribute moral responsibility to collective agents would require showing that they are capable of moral reasoning. It is argued here that those theories that understand collective reasoning and collective moral agency in terms of collective decision-making and commitment – as is arguably the case with Christian List and Philip Pettit’s theory of group agency – face the so-called “problem of the first belief” that threatens to make moral reasoning impossible for gr…

Soil quality indicators as affected by a long term barley-maize and maize cropping systems

2011

Most soil studies aim a better characterization of the system through indicators. In the present study nematofauna and soil structure were chosen as indicators to be assess soil health as related to agricultural practices. The field research was carried out on the two fodder cropping systems continuous maize (CM, Zea mays L.) and a 3-year rotation of silage-maize – silage-barley (Hordeum vulgare L.) with Italian ryegrass (R3) and grain-maize maintained in these conditions for 18 years. Each crop system was submitted to two management options: 1) the high input level (H), done as a conventional tillage, 2) the low input level (L), where the tillage was replaced by harrowing and the…

CCDC 2058017: Experimental Crystal Structure Determination

2021

Related Article: Xuelin Yao, Wenhao Zheng, Silvio Osella, Zijie Qiu, Shuai Fu, Dieter Schollmeyer, Beate Müller, David Beljonne, Mischa Bonn, Hai I. Wang, Klaus Müllen, Akimitsu Narita|2021|J.Am.Chem.Soc.|143|5654|doi:10.1021/jacs.1c01882

Stochastic order characterization of uniform integrability and tightness

2013

We show that a family of random variables is uniformly integrable if and only if it is stochastically bounded in the increasing convex order by an integrable random variable. This result is complemented by proving analogous statements for the strong stochastic order and for power-integrable dominating random variables. Especially, we show that whenever a family of random variables is stochastically bounded by a p-integrable random variable for some p>1, there is no distinction between the strong order and the increasing convex order. These results also yield new characterizations of relative compactness in Wasserstein and Prohorov metrics.

Large systems of path-repellent Brownian motions in a trap at positive temperature

2006

We study a model of $ N $ mutually repellent Brownian motions under confinement to stay in some bounded region of space. Our model is defined in terms of a transformed path measure under a trap Hamiltonian, which prevents the motions from escaping to infinity, and a pair-interaction Hamiltonian, which imposes a repellency of the $N$ paths. In fact, this interaction is an $N$-dependent regularisation of the Brownian intersection local times, an object which is of independent interest in the theory of stochastic processes. The time horizon (interpreted as the inverse temperature) is kept fixed. We analyse the model for diverging number of Brownian motions in terms of a large deviation princip…

Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.

1999

Metabolic activation of the strongly carcinogenic polycyclic aromatic hydrocarbon (PAH) dibenzo[a,l]pyrene (DB[a,l]P) and its trans-8,9-dihydrodiol (trans-8,9-diol) catalyzed by human cytochromes P450 (P450) 1A1 and 1B1 was investigated. DNA binding of DB[a,l]P in mammalian cell lines has previously been shown to be preferentially mediated by fjord region DB[a,l]P-11,12-dihydrodiol 13,14-epoxides (DB[a,l]PDE). In order to elucidate different capabilities of both P450 enzymes for metabolic activation of DB[a, l]P V79 Chinese hamster cells, stably expressing human P450s 1A1 or 1B1 have been exposed to the parent PAH or its racemic trans-8, 9-diol. For this purpose, synthesis and spectroscopic…

Influence of Ecklonia maxima Extracts on Growth, Yield, and Postharvest Quality of Hydroponic Leaf Lettuce

2021

Ecklonia maxima is a brown algae seaweed largely harvested over the last years and used to produce alginate, animal feed, fertilizers, and plant biostimulants. Their extracts are commercially available in various forms and have been applied to many crops for their growth-promoting effects which may vary according to the treated species and doses applied. The aim of the study was to characterize the effect of adding an Ecklonia maxima commercial extract (Basfoliar Kelp