Search results for "BCR"

Pattern formation driven by cross-diffusion

2009

In this work we are interested in describing the mechanism of pattern formation for a reaction-diffusion system with nonlinear diffusion terms (which take into account the self and the cross-diffusion effects). The reaction terms are chosen of the Lotka-Volterra type in the competitive interaction case. The cross-diffusion is proved to be the key mechanism of pattern formation via a linear stability analysis. A weakly nonlinear multiple scales analysis is carried out to predict the amplitude and the form of the pattern close to the bifurcation threshold. In particular, the Stuart-Landau equation which rules the evolution of the amplitude of the most unstable mode is found. In the subcritica…

Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism.

2014

Background Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL oncoprotein, with a constitutive tyrosine kinase activity. Consequently, BCR-ABL causes increased proliferation, inhibition of apoptosis, and altered adhesion of leukemic blasts to the bone marrow (BM) microenvironment. It has been well documented that cancer cells can generate their own signals in order to sustain their growth and survival, and recent studies have revealed the role of cancer-derived exosomes in activating signal transduction pathways involved in cancer cell…

Influencia de la colocación de implantes a nivel crestal y subcrestal en la remodelación del hueso periimplantario y la superficie rugosa expuesta. E…

2018

Objetivo: Evaluar, a los 36 meses de seguimiento, los parámetros clínicos y radiológicos periimplantarios tras la colocación de implantes a nivel crestal y subcrestal. Material y método: Se realizó un ensayo clínico aleatorizado de pacientes que requerían la colocación de un implante unitario interdental para remplazar su espacio desdentado y/o parcialmente desdentado que requerían implantes para sustituir 2 o 3 dientes ausentes. Los pacientes fueron aleatorizados según la profundidad de inserción del implante: implante test (implantes colocados aproximadamente 2 mm por debajo de la cresta ósea) o implante control (implantes colocados a nivel de la crestal ósea). Se revisó a los pacientes a…

Análisis de la anchura de la cortical vestibular en dientes anteriores maxilares y en la planificación virtual de implantes mediante tomografías comp…

2021

La evaluación del grosor de la cortical vestibular proporciona al clínico una herramienta de pronóstico para estimar el grado de pérdida ósea futura antes de la extracción del diente. En cuanto al grosor de cortical vestibular periimplantaria para asegurar la estabilidad ósea, se ha sugerido una anchura mínima de 1.8-2 mm. Objetivos 1. Determinar el grosor de la cortical vestibular en incisivos y caninos maxilares. 2. Comparar el grosor de la cortical vestibular en el primer y segundo premolar maxilar. 3. Evaluar la influencia de la distancia LAC-Cresta ósea vestibular con la anchura de la cortical vestibular en incisivos y caninos maxilares. 4. Estudiar en planificaciones virtuales de impl…

V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenou…

2010

Abstract Imatinib mesylate (imatinib), a competitive inhibitor of the BCR-ABL tyrosine kinase, is highly effective against chronic myelogenous leukemia (CML) cells. However, because 20–30% of patients affected by CML display either primary or secondary resistance to imatinib, intentional activation of Vγ9Vδ2 T cells by phosphoantigens or by agents that cause their accumulation within cells, such as zoledronate, may represent a promising strategy for the design of a novel and highly innovative immunotherapy capable to overcome imatinib resistance. In this study, we show that Vγ9Vδ2 T lymphocytes recognize, trogocytose, and efficiently kill imatinib-sensitive and -resistant CML cell lines pre…

A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

2015

Background: Na+/H+ exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them. Methods: A MEDLINE search for original and review articles using key terms, Na+/H+ exchanger, leukemia, cariporide, and …

Breast Cancer-Related Lymphedema: Prevalence, Risk Factors and Surgical Treatment

BCR-ABL as a target for novel therapeutic interventions.

2002

The BCR-ABL oncogene is the result of a reciprocal translocation between the long arms of chromosome 9 and 22 t(9; 22). There is good experimental evidence demonstrating that BCR-ABL is the single causative abnormality in chronic myeloid leukaemia (CML), making it a unique model for the development of molecular targets. In addition to CML, BCR-ABL transcripts can be found in a minority of acute lymphoblastic leukaemias and very rarely in acute myeloid leukaemia (AML). Elucidating the molecular mechanisms and downstream pathways of BCR-ABL has led to the design of several novel therapeutic approaches. In this review, molecular targeting of BCR-ABL will be discussed based on the inhibition of…

Cationic lipide mediated transfer of c-abl and bcr antisense oligonucleotides to immature normal myeloid cells: Uptake, biological effects and modula…

1996

Uptake and biochemical and biological effects of antisense oligodeoxynucleotides (ODN) specific for c-abl and bcr genes were studied in normal immature myeloid cells. CD34-positive cells were purified by positive and negative selection and cultured in liquid culture for 7 days. These cells were then incubated with ODNs, either alone or in combination with cationic lipids. The uptake of ODNs was enhanced by the use of cationic lipids. In addition, very low concentrations of ODNs in combination with cationic lipids were capable of specifically inhibiting the expression of the c-abl gene. In contrast, no effects were seen on the expression of bcr. However, despite the effective blocking of c-a…

B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma

2023

Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells’ signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells’ signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with …