Search results for "BINOL"
showing 10 items of 41 documents
Modulation of neuronal plasticity by events produced in adolescence: role of environmental enrichment and cannabis consumption
2017
Según Linda Spear, la adolescencia es un período de transición entre la juventud y la madurez, caracterizado por la toma de riesgos a nivel de conductual, pero también por un aumento de las hormonas sexuales (Spear, 2000). Además, hay una transformación importante en el cerebro adolescente, particularmente en el hipocampo, la amígdala y la corteza prefrontal. En esas zonas, así como en otras, durante este período se produce una remodelado dendrítico, una intensa mielinización y un fortalecimiento de la neurocircuitería. Las monoaminas dopamina, serotonina y melatonina participan en estos procesos y son cruciales en el comportamiento del adolescente (Arain et al., 2013). Además, en este perí…
IN-UTERO Δ9-TETRAHYDROCANNABINOL EXPOSURE IMPINGES ON BRAIN EXECUTIVE PROCESSES TOWARDS EMOTIONAL, COGNITIVE IMPAIRMENT, AND ALCOHOL VULNERABILITY IN…
2022
Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB 1 receptors on developing cortical neurons
2015
The CB1 cannabinoid receptor, the main target of Δ(9)-tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of its manipulation in animal models. Likewise, recreational cannabis use during pregnancy affects brain structure and function of the progeny. However, the precise neurobiological substrates underlying the consequences of prenatal THC exposure remain unknown. As CB1 signaling is known to modulate long-range corticofugal connectivity, we analyzed the impact of THC exposure on cortical projection neuron development. THC administration to pregnant mice in…
Analysis of Contact Traces of Cannabis by In-Tube Solid-Phase Microextraction Coupled to Nanoliquid Chromatography
2018
Because of its inherent qualities, in-tube solid-phase microextraction (IT-SPME) coupled on-line to nanoliquid chromatography (nanoLC) can be a very powerful tool to address the new challenges of analytical laboratories such as the analysis of traces of complex samples. This is the case of the detection of contact traces of drugs, especially cannabis. The main difficulties encountered in the analysis of traces of cannabis plants on surfaces are the low amount of sample available (typically <
Cannabis Influences the Putative Cytokines-Related Pathway of Epilepsy among Egyptian Epileptic Patients
2019
The study aims to investigate: (1) the prevalence of cannabis among epileptic patients seen at Mansoura University Hospital, (2) serum levels and gene expression of cytokines in epilepsy patients and the controls. and (3) the possibility that cannabis use affects the cytokine levels in epilepsy patients, triggering its future use in treatment. We recruited 440 epilepsy patients and 200 controls matched for age, gender, and ethnicity. Of the epileptic patients, 37.5% demonstrated lifetime cannabis use with a mean duration of 15 ±
Stability of 11-Nor-Δ9-carboxy-tetrahydrocannabinol Glucuronide in Plasma and Urine Assessed by Liquid Chromatography-Tandem Mass Spectrometry
2002
Abstract Background: Unconjugated 11-nor-Δ9-carboxy-tetrahydrocannabinol (THCCOOH) in blood and urine has been proposed as a valuable marker, but the glucuronide (THCCOOglu) is present in considerably higher concentrations than the parent drug. Acyl glucuronides have been shown to be potentially reactive conjugates, which may affect the in vitro metabolite pattern. Methods: Extraction procedures and a liquid chromatography-tandem mass spectrometry assay were developed and validated to investigate the stability of THCCOOglu in urine and plasma. Plasma and urine samples with added THCCOOglu were stored at −20, 4, 20, and 40 °C up to 10 days. Results: The glucuronide was stable at −20 °C in bo…
One‐pot synthesis of [2+2]‐helicate‐like macrocycle and 2+4‐μ4‐oxo tetranuclear open frame complexes : Chiroptical properties and asymmetric oxidativ…
2020
Synthesis of binuclear Cu(II) terminally closed [2+2]‐ double‐stranded helicate‐like macrocycles 1, 1′,1″, 2, 2′, 2″ and 2+4‐μ4‐oxo tetranuclear open frame complexes 3, 3′, 3″, 4, 4′, 4″ are established. Adapting one‐pot self‐assembly technique from simple three components systems: 1,1′‐binaphthyl‐2,2′‐diamine, 4‐methyl‐2,6‐diformyl phenol and cupric salts, the helicate‐like [2+2]‐ macrocyclic complexes 1–1″, 2–2″ and 2+4‐μ4‐oxo tetranuclear complexes 3–3″, 4–4″ were obtained by appropriately altering the reaction condition such as temperature and subcomponent ratio. Density Functional Theory (DFT) calculations were carried out for understanding the structural geometries, intermediates invo…
Latvijā legālie kaņepju preparāti un to izmantošana Latvijas iedzīvotāju vidū
2022
Kaņepju preparāti ir gan vēsturiski, gan mūsdienās aktuāls līdzeklis, ko izmanto gan skaistumkopšanā, gan medicīniskiem nolūkiem, gan arī uzturā. Tie kļuvuši īpaši populāri kā uztura bagātinātāji ikdienas dzīvēs cilvēkiem, lai uzlabotu dzīves kvalitāti, papildinot uzturu ar vērtīgajām vielām, ko satur kaņepes. Kanabinoīdi no kaņepju auga uz organismu iedarbojas caur endokanabinoīdu sistēmu. Pētījuma mērķis ir apkopot datus par Latvijas iedzīvotāju informētību par legālajiem kaņepju preparātiem un par parametriem, kas saistīti ar šo preparātu lietošanu. Rezultāti liecina, ka arī starp Latvijas iedzīvotajiem kaņepju preparāti ir zināmi un tiek izmantoti dažādiem potenciāliem ieguvumiem, kurie…
Kaņepju auga iegūšanas, izplatīšanas, izmantošanas uzturā un medicīniskiem nolūkiem - tiesiskais regulējums Eiropas Savienībā, starptautiskajās tiesī…
2020
Kaņepju augu šķiedra, sēklas, ziedi un lapas jau tūkstošiem gadu ir tikušas izmantotas gan dažādu sadzīves, gan pārtikas produktu pagatavošanai, kā arī medicīniskiem un atpūtas nolūkiem, tomēr daudzu politisku iemeslu dēļ 20.gs vidū daudzviet pasaulē šī auga izmantošana tika aizliegta, jo kaņepju sastāvā tika atklāta viela tetrahidrokanabinols, kas ir psihoaktīva un atkarību izraisoša viela. Turklāt 20.gs. 60.gados kaņepju izmantošanas aizliegumu sāka noteikt starptautiskā līmenī, tomēr vēlāk kaņepes atļāva audzēt šķiedras un sēklu ieguvei, kā arī dārzkopības mērķiem. Neraugoties uz pastāvošajiem ierobežojumiem, interese par kaņepju augiem sabiedrībā nav zudusi, tieši pretēji – palielinājus…
Stability of Cannabinoids in Hair Samples Exposed to Sunlight
2000
It has been well recognized that hashish and marihuana lose potency during storage because of a decrease in the content of tetrahydrocannabinol (THC), which is the major psychoactive constituent of cannabis (1). The effect of oxygen on stored plant and resin materials or solutions of pure cannabinoids seems much less significant than that of higher temperatures (≥37 °C) or light (2)(3)(4)(5)(6)(7). A few data are available on the stability of THC and major metabolites in blood (8)(9)(10)(11). However, the stability of cannabinoids in the hair shaft has not been addressed, although scalp hair represents one of the most exposed parts of the body. Therefore, a study was performed to elucidate …