Search results for "BIP"
showing 10 items of 1908 documents
The extent of adhesion induction through electrocoagulation and suturing in an experimental rat study.
2008
Objective To investigate the effect of three types of peritoneal trauma occurring during surgery (high-frequency bipolar current, suturing, and mechanical damage) on postoperative adhesion formation in a rodent animal model. Design Randomized, controlled experimental trial in an in vitro animal model. Setting Laboratory facilities of a university department of obstetrics and gynecology. Animal(s) Thirty-five female Wistar rats. Intervention(s) Bilateral experimental lesions were created on the abdominal wall in every animal. The effect of minimal electrocoagulation was examined by creating lesions (n = 14) through sweeps of a bipolar forceps with a duration of 1 second and standardized pres…
What we learn about bipolar disorder from large-scale neuroimaging
2020
Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…
Endofenotipos neurocognitivos potenciales para el trastorno bipolar: velocidad motora manual, memoria visual, velocidad de procesamiento
2017
Antecedentes: Son pocas las investigaciones que se centran en el estudio de las disfunciones neurocognitivas en pacientes con trastorno bipolar (TB) como posibles marcadores de rasgo para esta enfermedad, menos aún son las que comparan el rendimiento motor, la memoria visual o la velocidad de procesamiento de la información, en estudios transversales o longitudinales, incluyendo a la vez, controles (CS) y familiares sanos de primer grado de los pacientes (TB-F); hasta la redacción de esta tesis, aunque el número va en aumento, en la investigación psiquiátrica el trastorno bipolar sigue ocupando un lugar secundario frente a la esquizofrenia, siendo insuficientes los estudios que buscan evide…
Zastosowanie metody BIPOLAR na przykładzie problemu wyboru dostawcy usług logistycznych
2018
Idea metody BIPOLAR polega na tym, że warianty decyzyjne nie są porównywane bezpośrednio ze sobą a z zestawami rozwiązań wskazanych jako referencyjne. Takie porównanie umożliwia sprawdzenie czy istnieją przesłanki do uznania danego wariantu za mający przewagę nad każdym z pozostałych. Zbiór rozwiązań nazywa się zbiorem punktów referencyjnych, który zawiera rozwiązania dobre i złe. Metoda BIPOLAR uwzględnia wszystkie etapy procesu decyzyjnego: wybór kryteriów oraz określenie ich wag, modelowanie preferencji decydentów, wybór właściwego wariantu decyzyjnego na podstawie rankingu.
Single Event Transients and Pulse Quenching Effects in Bandgap Reference Topologies for Space Applications
2016
An architectural performance comparison of bandgap voltage reference variants, designed in a $0.18~\mu \text {m}$ CMOS process, is performed with respect to single event transients. These are commonly induced in microelectronics in the space radiation environment. Heavy ion tests (Silicon, Krypton, Xenon) are used to explore the analog single-event transients and have revealed pulse quenching mechanisms in analogue circuits. The different topologies are compared, in terms of cross-section, pulse duration and pulse amplitude. The measured results, and the explanations behind the findings, reveal important guidelines for designing analog integrated circuits, which are intended for space appli…
Comparison of decision variants with reference set (BIPOLAR method) in selection process of suppliers
2018
Bipolar is one of the Multiple Criteria Decision Analysis (MCDA) methods, proposed by Ewa Konarzewska-Gubała [6, 7, 8]. The essence of the analysis in the BIPOLAR method consists in a fact that alternatives are not compared directly to each other, but they are confronted to the two sets of reference objects: good and bad. Some alternatives can be evaluated as over good, i.e. better than at least one of desirable reference object or underbid, i.e. worse than at least of one nonacceptable object. Proposed method takes into account all stages of the decision-making process, starting with the selection of criteria and determining their weights, by modelling the preferences of decision-makers, o…
Sexual dimorphism in the vertebral wedging of the human lumbar vertebrae and its importance as a comparative framework for understanding the wedging …
2020
Lumbar lordosis is a key element of the upright posture, being interpreted as a consequence of bipedal locomotion. There is consensus that the generic modern human pattern of metameric vertebral body wedging is sexually dimorphic in modern humans. However, recently published studies have compared this pattern with other hominins, such as Neanderthals. These tried to establish whether the (male) Neanderthal lumbar vertebrae express a pattern that falls within or outside the range of modern human males. In the present study, data collected by 3D landmarks of the lumbar vertebrae of modern humans from different geographic regions and Neanderthals (Ntotal = 505 individual vertebrae) are used to…
A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.
2000
In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing of 10 cM in a series of 75 families, comprising 66 families from Germany, eight families from Israel, and one family from Italy. The families were ascertained through index cases with bipolar affective disorder. The distribution of diagnoses is as follows: 126 individuals with bipolar I disorder, 40 with bipolar II disorder, 14 with schizoaffective disorder of the bipolar type, 40 individuals with recurrent unipolar depression, 51 with a minor psychiatric diagnosis, and two individuals…
Hormesis: Decoding Two Sides of the Same Coin
2015
In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how t…
Endocrine disrupters: the new players able to affect the epigenome
2015
Epigenetics represents the way by which the environment is able to program the genome; there are three main levels of epigenetic control on genome: DNA methylation, post-translational histone modification and microRNA expression. The term Epigenetics has been widened by NIH to include “both heritable changes in gene activity and expression but also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.” These changes might be produced mostly by the early life environment and might affect health influencing the susceptibility to develop diseases, from cancer to mental disorder, during the entire life span. The most studied environmental i…