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RESEARCH PRODUCT
What we learn about bipolar disorder from large-scale neuroimaging
Christian K. TamnesBartholomeus C M HaarmanJair C. SoaresOle A. AndreassenOle A. AndreassenViola OertelTheodore D. SatterthwaiteG. TronchinMichael StäbleinBradley J. MacintoshBradley J. MacintoshMelissa PaulingChristopher R.k. ChingDaniel H. WolfDick J. VeltmanIngrid AgartzIngrid AgartzBernhard T. BauneBernhard T. BauneBernhard T. BauneSalvador SarróMon-ju WuScott C FearsVieta EduardMelissa J. GreenMelissa J. GreenNeeltje E.m. Van HarenYann QuidéYann QuidéErlend BøenYash PatelIgor NenadicMartin AldaLisa T. EylerArnaud PouchonDanai DimaDanai DimaTomáš PausTomáš PausIrene BollettiniTorbjørn ElvsåshagenTorbjørn ElvsåshagenRachel M. BrouwerLakshmi N. YathamMichael BauerCaterina Del Mar BonnínC. McdonaldUdo DannlowskiBronwyn OversEdith Pomarol-clotetCristian Vargas UpeguiOliver GruberHenricus G. RuhéMárcio Gerhardt Soeiro-de-souzaEdouard DuchesnayHilary P. BlumbergTilo KircherMiho OtaMichael BerkMichael BerkChristoph AbéChristoph AbéAndreas JansenKang SimHeather C. WhalleyDerrek P. HibarRoel A. OphoffRoel A. OphoffGeorgios V ThomaidisHenrik WalterSophia FrangouSophia FrangouMichèle WessaDara M. CannonCara M. AltimusAllison C. NugentRodrigo Machado-vieiraOrwa DandashOrwa DandashMarcella BellaniUnn K. HaukvikPhilip B. MitchellLing-li ZengLing-li ZengChristian KnöchelJose Manuel GoikoleaSonja M C De ZwarteFrancesco BenedettiSara PolettiJanice M. FullertonJanice M. FullertonCarlos A. ZarateAart H. ScheneDan J. SteinChantal HenryTristram A. LettMikael LandénMikael LandénDaniel L PhamPaolo BrambillaPaolo BrambillaSilvia Alonso-lanaSophia I. ThomopoulosCarlos López-jaramilloTomas HajekTomas HajekBernd KramerG. DelvecchioMaria M. RiveLars T. WestlyeLars T. WestlyeErick Jorge Canales-rodríguezVictoria L. Ives-deliperiDominik GrotegerdBeny LaferAbraham NunesCarrie E. BeardenCarrie E. BeardenRaymond SalvadorJoaquim RaduaAmy C BilderbeckXavier CaserasPaul M. ThompsonJorge R. C. AlmeidaPauline FavreGloria RobertsDavid C. GlahnDag AlnæsJulian A Pineda-zapataTiril P. GurholtTiril P. GurholtMircea PolosanMircea PolosanJosselin HouenouFabiano G. NeryFabiano G. NeryLeila NabulsiLeila NabulsiMary L. PhillipsFleur M. HowellsAna M. Díaz-zuluagaElisa M T Mellonisubject
mega-analysisStress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]cortical surface areaReview Article0302 clinical medicineManic-depressive illnessMulticenter Studies as TopicSpectrum disorderReview Articlesbipolar disorderCerebral CortexTrastorn bipolarneuroimagingRadiological and Ultrasound Technology05 social sciencesENIGMAHUMAN BRAINMagnetic Resonance Imagingpsychiatry3. Good healthNeurologyMeta-analysisScale (social sciences)AnatomyPsychologyClinical risk factorClinical psychologyMRIMAJOR PSYCHIATRIC-DISORDERSSchizoaffective disorder050105 experimental psychology03 medical and health sciencesMagnetic resonance imagingNeuroimagingMeta-Analysis as TopicSDG 3 - Good Health and Well-beingImatges per ressonància magnèticamedicineHumans0501 psychology and cognitive sciencesRadiology Nuclear Medicine and imagingBipolar disorderHIPPOCAMPAL VOLUMESmega‐analysisGRAY-MATTER VOLUMESPECTRUM DISORDERvolumeDIABETES-MELLITUScortical thicknessCOGNITIVE IMPAIRMENTmedicine.diseaseMental illnessmeta-analysismeta‐analysisRC0321Neurology (clinical)SCHIZOAFFECTIVE DISORDERPSYCHOTIC FEATURES030217 neurology & neurosurgerydescription
Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large‐scale meta‐ and mega‐analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large‐scale, collaborative studies of mental illness.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-07-29 | Human Brain Mapping |