0000000000276509

AUTHOR

Lakshmi N. Yatham

showing 5 related works from this author

Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated …

2015

Abstract Background Animals show seasonal changes in the endocrine and immune system in response to winter stressors. Even though increased inflammation has been implicated in the pathophysiology of depression, whether immune disorder is a key mediator in seasonal affective depression (SAD) is unknown. Here, we hypothesized that short photoperiods in winter may induce inflammatory response, which contributes to SAD, and that light treatments should normalize immune function and improve depressive symptoms. Methods Twenty patients with a diagnosis of SAD, and a score on the HAM-29 of 20 or higher were recruited for this study. Twenty-one healthy subjects with no personal and family history o…

AdultMaleLight therapymedicine.medical_specialtymedicine.medical_treatmentLymphocyteLymphocyte proliferationProinflammatory cytokineInterferon-gammaInternal medicinemedicineAnimalsHumansLymphocytesInflammationAnalysis of VarianceTumor Necrosis Factor-alphaSeasonal Affective DisorderPhototherapymedicine.diseasePsychiatry and Mental healthClinical Psychologymedicine.anatomical_structureCytokineEndocrinologyImmunologyCytokinesMajor depressive disorderFemaleImmune disorderPsychologyHypothalamic–pituitary–adrenal axisInterleukin-1Journal of Affective Disorders
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Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report

2014

Objective: We discuss the rationale behind staging systems described specifically for bipolar disorders. Current applications, future directions and research gaps in clinical staging models for bipolar disorders are outlined. Method: We reviewed the literature pertaining to bipolar disorders, focusing on the first episode onwards. We systematically searched data on staging models for bipolar disorders and allied studies that could inform the concept of staging. Results: We report on several dimensions that are relevant to staging concepts in bipolar disorder. We consider whether staging offers a refinement to current diagnoses by reviewing clinical studies of treatment and functioning and t…

First episodeBipolar DisorderTask forceStandard treatmentDisease progressionAdvisory Committeesmedicine.diseaseSeverity of Illness IndexPsychiatry and Mental healthNeuroimagingmedicineDisease ProgressionHumansBipolar disorderMedical diagnosisPsychologyNeurocognitiveBiomarkersSocieties MedicalClinical psychology
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Assessment and management of agitation in psychiatry: Expert consensus

2016

International audience; BACKGROUND:Psychomotor agitation is associated with different psychiatric conditions and represents an important issue in psychiatry. Current recommendations on agitation in psychiatry are not univocal. Actually, an improper assessment and management may result in unnecessary coercive or sedative treatments. A thorough and balanced review plus an expert consensus can guide assessment and treatment decisions.METHODS:An expert task force iteratively developed consensus using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new, re-worded or re-rated items.RESULTS:Out of 2175 papers assessing psychomo…

medicine.medical_specialtyEmergency Medical ServicesConsensusPsychomotor agitationassessmentDelphi methodverbal de-escalation03 medical and health sciencesBenzodiazepines0302 clinical medicineMeta-Analysis as TopicRisk FactorsmedicineHumansPsychiatryPsychomotor AgitationBiological PsychiatryAgitation assessment psychiatric emergency restraint verbal de-escalationRandomized Controlled Trials as TopicPsychiatric Status Rating ScalesPsychiatryAgitationTask forceExpert consensusDisease ManagementEvidence-based medicinepsychiatric emergency3. Good health030227 psychiatryAgitation; assessment; psychiatric emergency; restraint; verbal de-escalation; Biological Psychiatry; Psychiatry and Mental HealthOlanzapinePsychiatry and Mental Healthrestraint[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthPractice Guidelines as TopicTreatment decision makingmedicine.symptomBiological psychiatryPsychology030217 neurology & neurosurgeryAntipsychotic Agents
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What we learn about bipolar disorder from large-scale neuroimaging

2020

Abstract MRI‐derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta‐Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis‐driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Workin…

mega-analysisStress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]cortical surface areaReview Article0302 clinical medicineManic-depressive illnessMulticenter Studies as TopicSpectrum disorderReview Articlesbipolar disorderCerebral CortexTrastorn bipolarneuroimagingRadiological and Ultrasound Technology05 social sciencesENIGMAHUMAN BRAINMagnetic Resonance Imagingpsychiatry3. Good healthNeurologyMeta-analysisScale (social sciences)AnatomyPsychologyClinical risk factorClinical psychologyMRIMAJOR PSYCHIATRIC-DISORDERSSchizoaffective disorder050105 experimental psychology03 medical and health sciencesMagnetic resonance imagingNeuroimagingMeta-Analysis as TopicSDG 3 - Good Health and Well-beingImatges per ressonància magnèticamedicineHumans0501 psychology and cognitive sciencesRadiology Nuclear Medicine and imagingBipolar disorderHIPPOCAMPAL VOLUMESmega‐analysisGRAY-MATTER VOLUMESPECTRUM DISORDERvolumeDIABETES-MELLITUScortical thicknessCOGNITIVE IMPAIRMENTmedicine.diseaseMental illnessmeta-analysismeta‐analysisRC0321Neurology (clinical)SCHIZOAFFECTIVE DISORDERPSYCHOTIC FEATURES030217 neurology & neurosurgeryHuman Brain Mapping
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Consensus on nomenclature for clinical staging models in bipolar disorder: A narrative review from the International Society for Bipolar Disorders (I…

2021

Objectives Clinical staging is widely used in medicine to map disease progression, inform prognosis and guide treatment decisions; in psychiatry, however, staging remains a hypothetical construct. To facilitate future research in bipolar disorders (BD), a well-defined nomenclature is needed, especially since diagnosis is often imprecise with blurred boundaries, and a full understanding of pathophysiology is lacking. Methods Under the auspices of the International Society of Bipolar Disorders, a Task Force of international experts was convened to review, discuss, and integrate findings from the scientific literature relevant to the development of a consensus staging model and standardize a t…

medicine.medical_specialtyBipolar DisorderConsensusHeterogeneous groupTask forceAdvisory CommitteesDisease progressionScientific literaturePrognosisInternational Standard Bibliographic Descriptionmedicine.diseaseTerminologyPsychiatry and Mental healthSDG 3 - Good Health and Well-beingDisease ProgressionmedicineHumansNarrative reviewMedical physicsBipolar disorderPsychologyBiological PsychiatryBipolar Disorders
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