Search results for "BM"

Comparative Proteome Profiling and Functional Analysis of Chronic Myelogenous Leukemia Cell Lines

2007

The aim of the present study was the molecular profiling of different Ph+ chronic myelogenous leukemia (CML) cell lines (LAMA84, K562, and KCL22) by a proteomic approach. By employing two-dimensional gel electrophoresis combined with mass spectrometry analysis, we have identified 191 protein spots corresponding to 142 different proteins. Among these, 63% were cancer-related proteins and 74% were described for the first time in leukemia cells. Multivariate analysis highlighted significant differences in the global proteomic profile of the three CML cell lines. In particular, the detailed analysis of 35 differentially expressed proteins revealed that LAMA84 cells preferentially expressed prot…

RESVEGA, a Nutraceutical Omega-3/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization

2021

Age-related macular degeneration (AMD) is an eye disease that is characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. At an advanced stage, a blind spot grows in the center of vision, severely handicapping patients with this degenerative condition. Despite therapeutic advances thanks to the use of anti-VEGF, many resistance mechanisms have been found to accentuate the visual deficit. In the present study, we explored whether supplementation with Resvega®, a nutraceutical formulation composed of omega-3 fatty acids and resveratrol, a well-known polyphenol in grapes, was able to counteract laser-induced choroidal neovascularizat…

Technical improvements for analysis of recalcitrant proteins by LC-MS : the myccorhiza responsive membrane proteome as a case study

2012

Arbuscular mycorrhizas (AM) are widespread symbiotic associations between plant roots and AM fungi. Deep membrane alterations are the foremost morphological changes occurring in the host plant in response to AM symbiosis. Two-dimensional gel electrophoresis (2-DE) is the workhorse method in AM proteomics. Membrane proteins are under-represented in 2-DE because of their hydrophobicity, low abundance, and precipitation at their isoelectric point, thereby few are the identified membrane proteins involved in sustaining the AM symbiosis. Membrane proteomics is still challenging due to 2-DE related shortcomings, however latest trends and advancements in mass spectrometry (MS)-based quantitative p…

Scientific Publications and Research Groups on Alcohol Consumption and Related Problems Worldwide: Authorship Analysis of Papers Indexed in PubMed an…

2011

BACKGROUND: The research of alcohol consumption-related problems is a multidisciplinary field. The aim of this study is to analyze the worldwide scientific production in the area of alcohol-drinking and alcohol-related problems from 2005 to 2009. METHODS: A MEDLINE and Scopus search on alcohol (alcohol-drinking and alcohol-related problems) published from 2005 to 2009 was carried out. Using bibliometric indicators, the distribution of the publications was determined within the journals that publish said articles, specialty of the journal (broad subject terms), article type, language of the publication, and country where the journal is published. Also, authorship characteristics were assesse…

Advice for health-care professionals on how to retrieve more efficiently scientifically strong and up-to-date studies on treatments by PubMed.

2008

AND trial (Title/Abstract))). Obviously, clini- cians using the PubMed Clinical Queries may be unaware of the PubMed search engine technical approach even whether they can remain unaware of what the PubMed search engine is doing. We demonstrated substantial mild retrieval bias of PubMed Clinical Queries filter focusing on therapy (narrow search) that can miss up-to-date scientifically information on treatments. This bias occurs because the search string does not consider the Britannic English variant of the term randomized (i.e., randomised). We suggested a slight change in the original search string by the addition of the term randomised as follows: (randomized controlled trial (Publicatio…

The case of homeopathy, “how to search PubMed” may be a first step

2017

Waterfront and Transformation in Contexts of Conflict

2016

This chapter defines in what way the seaside and the waterfront can be place of conflicts among infrastructures, production, unplanned urbanisation, bathing tourism and many other activities. The last section of the chapter describes synthetically the study case of Saint-Nazare Submarine base and the terms of regeneration of a typically place of conflict, like a military area connected with the waterfront. The transformations underway in the waterfront areas present a variety of complex settlement dynamics that are ascribable to the infrastructural and productive nature of many activities, such as unplanned urbanisation, the pressures of bathing tourism and mass tourism, and the system of s…

Conoscere e usare Pubmed. Guida al più noto sistema di ricerca bibliografica in campo biomedico. II edizione.

2008

Reduced apoptosis of CD8+ T-Lymphocytes in the airways of smokers with mild/moderate COPD

2011

SummaryChronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation in airways and lung parenchyma. CD8+ T-lymphocytes, crucial effector and regulatory cells in inflammation, are increased in the central and peripheral airways in COPD. The aim of this study was to assess the role of apoptosis in the accumulation of CD8+ T-lymphocytes within the airway wall in COPD. We examined the submucosa of transverse sections of central and peripheral airways from post-operative tissues from non-smokers (n = 16), smokers with normal lung function (n = 16), smokers with mild/moderate COPD (n = 16), and smokers with severe/very severe COPD (n = 9). TUNEL and immunohistochemistry t…

On the structure of the similarity orbits of Jordan operators as analytic homogeneous manifolds

1989

For Jordan elementsJ in a topological algebraB with unite, an open groupB−1 of invertible elements and continuous inversion we consider the similarity orbitsS G (J)={gJg−1:g∈G} (G the groupB−1⋂{e+c:c∈I},I⊂B a bilateral continuous embedded topological ideal). We construct rational local cross sections to the conjugation mapping\(\pi ^J G \to S_G \left( J \right)\left( {\pi ^J \left( g \right) = gJg^{ - 1} } \right)\) and give to the orbitS G (J) the local structure of a rational manifold. Of particular interest is the caseB=L(H) (bounded linear operators on a separable Hilbert spaceH),I=B, for which we obtain the following: 1. If for a Hilbert space operator there exist norm continuous local…