Search results for "BN"
showing 10 items of 1136 documents
NT-pro-BNP nozīme agrīnā HSM diagnostikā 2. tipa cukura diabēta pacientiem
2020
Ievads. Pacientiem ar otrā tipa cukura diabētu ir ievērojami lielāks risks attīstīties kardiovaskulārai slimībai. Lielai daļai pacientu ar otrā tipa diabētu var attīstīties kardiovaksulāra saslimšana bez tipiskas klīniskās ainas, kā rezultātā kardiovaskulāru slimību diagnosticē novēloti, kad tā jau ir progresējusi. Līdz ar to būtu svarīgi šiem pacientiem veikt skrīningu, lai priekšlaicīgi diagnosticētu vai novērstu kardiovaskulāru slimību attīstību – noteikt NT-pro-BNP. Pētījuma mērķis. Pētīt NT-pro-BNP izmaiņas otrā tipa cukura diabēta pacientiem, kuriem slimības vēsturē nav kardiovaskulāru saslimšanu, un vai NT-pro-BNP līmenim asinīs ir saistība pacienta dzimumu, vecumu un slimošanas ar o…
Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents
2000
Mammalian mismatch repair has been implicated in mismatch correction, the prevention of mutagenesis and cancer, and the induction of genotoxicity and apoptosis. Here, we show that treatment of cells specifically with agents inducing O(6)-methylguanine in DNA, such as N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea, elevates the level of MSH2 and MSH6 and increases GT mismatch binding activity in the nucleus. This inducible response occurs immediately after alkylation, is long-lasting and dose-dependent, and results from translocation of the preformed MutSalpha complex (composed of MSH2 and MSH6) from the cytoplasm into the nucleus. It is not caused by an increase in MSH2 gen…
Użycie słowa „czas” w Księdze Syracydesa
2020
Artykuł ma na celu przedstawienie użycia słowa „czas” w Księdze Syracydesa. W tym celu autor syntetycznie ukazał najpierw pole semantyczne terminu „czas” w języku hebrajskim i greckim. Następnie, na podstawie wskazanych rozróżnień, zostały przedstawione fragmenty, w których pojawia się omawiany termin, z uwzględnieniem kontekstu całej księgi, jak i pozostałych ksiąg biblijnych. Dla mędrca z Jerozolimy czas nie jest jedynie pojęciem wyznaczającym chronologię, ale rzeczywistością, którą codziennie człowiek odkrywa jako sposobność do czynienia dobra i przestrzeń działania Boga jako Stwórcy i Pana całego stworzonego świata. Różnorodność sytuacji życiowych, które przedstawia Ben Syrach w swej ks…
Motores de búsqueda y derechos de autor: infracción y responsabilidad
2015
Los motores de búsqueda se configuran como herramientas indispensables para localizar fácilmente cualquier tipo de información entre las más de tres billones de páginas web existentes en la red. Estos buscadores se presentan, de facto, como instrumentos básicos para que todo usuario pueda tener acceso a la información, cultura y educación, de manera que están convirtiéndose en unas herramientas indispensables para el libre desarrollo de las personas. Sin embargo, a pesar de estas ventajas, en ocasiones, los buscadores vuelcan contenidos protegidos en la página de resultados sin autorización de su titular, de forma que de no mediar algún límite o excepción tasado en la ley, pueden estar vuln…
Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a target in LKB1 Mutant Lung Cancer
2013
Abstract The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism. In non–small cell lung carcinoma, LKB1 is somatically inactivated in 25% to 30% of cases, often concurrently with activating KRAS mutations. Here, we used an integrative approach to define novel therapeutic targets in KRAS-driven LKB1-mutant lung cancers. High-throughput RNA interference screens in lung cancer cell lines from genetically engineered mouse models driven by activated KRAS with or without coincident Lkb1 deletion led to the identification of Dtymk, encoding deoxythymidylate kinase (DTYMK), which catalyzes dTTP biosynthesis, as synthetica…
Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus
2012
Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γ 3H2AX-positive cells in cell lines derived from two affected individual…
Search for Technicolor Particles Produced in Association with a W Boson at CDF
2010
7 páginas, 3 figuras, 1 tabla.-- PACS numbers: 14.80.Tt, 12.60.Nz, 13.85.Rm.-- CDF Collaboration: et al.
Limit on the production of a light vector gauge boson in $\phi $ mesondecays with the KLOE detector
2012
We present a new limit on the production of a light dark-force mediator with the KLOE detector at DAPHNE. This boson, called U, has been searched for in the decay phi --> eta U, U --> e+ e-, analyzing the decay eta --> pi0 pi0 pi0 in a data sample of 1.7 fb-1. No structures are observed in the e+e- invariant mass distribution over the background. This search is combined with a previous result obtained from the decay eta --> pi+ pi- pi0, increasing the sensitivity. We set an upper limit at 90% C.L. on the ratio between the U boson coupling constant and the fine structure constant of alpha'/alpha < 1.7x10^-5 for 30<M_U<400 MeV and alpha'/alpha < 8x10^-6 for the sub-region 50<M_U<210 MeV. This…
Parameter Rating by Diffusion Gradient
2014
Anomaly detection is a central task in high-dimensional data analysis. It can be performed by using dimensionality reduction methods to obtain a low-dimensional representation of the data, which reveals the geometry and the patterns that exist and govern it. Usually, anomaly detection methods classify high-dimensional vectors that represent data points as either normal or abnormal. Revealing the parameters (i.e., features) that cause detected abnormal behaviors is critical in many applications. However, this problem is not addressed by recent anomaly-detection methods and, specifically, by nonparametric methods, which are based on feature-free analysis of the data. In this chapter, we provi…
Fragile X-syndrome: literature review and report of two cases
2009
Fragile X-syndrome is caused by a mutation in chromosome X. It is one of the most frequent causes of learning disability. The most frequent manifestations of fragile X-syndrome are learning disability, different orofacial morphological alterations and an increase in testicle size. The disease is associated with cardiac malformations, joint hyperextension and behavioural alterations. We present two male patients aged 17 and 10 years, treated in our Service due to severe gingivitis. Both showed the typical facial and dental characteristics of the syndrome. In addition, we detected the presence of root anomalies such as taurodontism and root bifurcation, which had not been associated with frag…