Search results for "BOS"
showing 10 items of 3713 documents
Platelet cut-off for anticoagulant therapy in thrombocytopenic patients with blood cancer and venous thromboembolism: an expert consensus
2019
Background. Management of venous thromboembolism (VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the related risks. No prospective studies or clinical trials have been carried out and, therefore, no solid evidence on this compelling issue is available. Methods. Given this, an expert panel endorsed by the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on Thrombosis and Haemostasis was set up to produce a formal consensus, according to the RAND method, in order to issue clinical recommendations about the platelet (PLT) cut-off for safe administration of low molecular weight heparin (LMWH) in thrombocytopenic (PLT <100×…
Factors associated with the timing of diagnosis of venous thromboembolism: results from the MASTER registry
2008
INTRODUCTION: Signs and symptoms of venous thromboembolism (VTE) are non-specific and thus can make diagnosis difficult, even for an experienced clinician. We aimed to evaluate the timing of diagnosis of deep vein thrombosis (DVT) and pulmonary embolism (PE) in Italian hospitals and to identify individual and clinical predictors of timely or delayed diagnosis. MATERIAL AND METHODS: MASTER is a multicenter prospective registry of patients with acute DVT and PE. Information on clinical presentation and diagnostic methods, temporary and permanent risk factors, were captured by an electronic data network at the time of the index event. RESULTS: Data on 2047 patients (1024 males), 1505 with DVT …
The MASTER registry on venous thromboembolism: description of the study cohort.
2008
L’impiego della carbossimetilcellulosa come alternativa alla stabilizzazione tartarica a freddo dei vini bianchi e rossi
2014
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture.
2003
Studies on the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high level. Analysis of the replicon population in selected cells revealed the occurrence of cell culture-adaptive mutations that enhance RNA replication substantially. To gain a better understanding of HCV cell culture adaptation, we characterized conserved mutations identified by sequence analysis of 26 independent replicon cell clones for their effect on RNA replication. Mutations enhancing replication were found in nearly every nonstructural (NS) protein, and they could be subdivided into at …
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
Phenomenological description of the vortex density in rotating BEC superfluids
2008
The close analogy of a purely magnetic excitation scheme, used in the experiments on Bose-Einstein condensate by Hodby et al., and the rotating bucket experiments with liquid helium 4 has suggested us to apply a phenomenological equation for the vortex line density, previously proposed for rotating superfluid helium 4, to describe the vortex density in a rotating Bose-Einstein condensate as a function of the angular speed. In both systems, the phenomenological equation provides a reasonable description of the observed data.
Measurement of parity-violating spin asymmetries in W± production at midrapidity in longitudinally polarized p+p collisions
2016
We present midrapidity measurements from the PHENIX experiment of large parity-violating singlespin asymmetries of high transverse momentum electrons and positrons from W =Z decays, produced in longitudinally polarized p þ p collisions at center of mass energies of ffiffi s p ¼ 500 and 510 GeV. These asymmetries allow direct access to the antiquark polarized parton distribution functions due to the parityviolating nature of the W-boson coupling to quarks and antiquarks. The results presented are based on data collected in 2011, 2012, and 2013 with an integrated luminosity of 240 pb−1, which exceeds previous PHENIX published results by a factor of more than 27. These high Q2 data probe the p…
Excess electronic recoil events in XENON1T
2020
We report results from searches for new physics with low-energy electronic recoil data recorded with the XENON1T detector. With an exposure of 0.65 t-y and an unprecedentedly low background rate of $76\pm2$ events/(t y keV) between 1 and 30 keV, the data enables sensitive searches for solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter. An excess over known backgrounds is observed at low energies and most prominent between 2 and 3 keV. The solar axion model has a 3.4$\sigma$ significance, and a 3D 90% confidence surface is reported for axion couplings to electrons, photons, and nucleons. This surface is inscribed in the cuboid defined by $g_{ae}<3.8 \times 10^{-12}$,…
Les églises doubles de Dalmatie et de Bosnie-Herzégovine
1996
Double churches with or without side annexes are quite common in the Roman province of Dalmatia. Sixteen double churches - 5% of the inventory of Dalmatia - were recorded in our work. Few churches were built at one time, more at different times. In the latter case, there may be an influence exercised by Salona and the wish to reproduce the churches of its episcopal group on a smaller scale. Other motivations must be taken into account; they can be of liturgical (baptismal, funerary, martyrial) and practical kind. But none were generally prouved. We have few examples with liturgical furnishings almost fully preserved in both buildings, showing similar functions.